Cholesterol Enhances Colorectal Cancer Progression via ROS Elevation and MAPK Signaling Pathway Activation

Background/Aims: Elevated serum cholesterol levels were linked to a higher risk of colorectal adenoma and colorectal cancer (CRC), while the effect of cholesterol on CRC metastasis has not been widely studied. Methods: CRC patients were enrolled to evaluate the association between low-density lipopr...

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Veröffentlicht in:	Cellular physiology and biochemistry 2017-01, Vol.42 (2), p.729-742
Hauptverfasser:	Wang, Caihua, Li, Peiwei, Xuan, Junmei, Zhu, Chunpeng, Liu, Jingjing, Shan, Lizhen, Du, Qin, Ren, Yuezhong, Ye, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Apoptosis Carcinogenesis - genetics Cell Line, Tumor Cell Proliferation - genetics Cholesterol Cholesterol - metabolism Cholesterol, LDL - genetics Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Diet, High-Fat Disease Progression Female Gene Expression Regulation, Neoplastic Humans Kinases Lipids Liver Neoplasms - genetics Liver Neoplasms - pathology Liver Neoplasms - secondary Male Metastasis Mice Middle Aged Neoplasm Proteins - biosynthesis Original Paper Reactive oxygen species Reactive Oxygen Species - metabolism ROS Signal Transduction - genetics Tumors
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