Ponatinib-Induced Graft-versus-Host Disease/Graft-versus-Leukemia Effect in a Patient with Philadelphia-Positive Acute Lymphoblastic Leukemia without the T315I Mutation Relapsing after Allogeneic Transplant

We describe the case of a patient with Philadelphia-positive acute lymphoblastic leukemia treated with dasatinib plus steroids as first-line therapy, who achieved a major molecular response (MMR) before undergoing matched, unrelated donor allogeneic stem cell transplant. Eleven months after the tran...

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Veröffentlicht in:	Chemotherapy (Basel) 2017-01, Vol.62 (6), p.353-356
Hauptverfasser:	Petrungaro, Annamaria, Gentile, Massimo, Mazzone, Carla, Greco, Rosa, Uccello, Giuseppina, Recchia, Anna Grazia, De Stefano, Laura, Bossio, Sabrina, Palummo, Angela, Morelli, Rosellina, Musolino, Caterina, Morabito, Fortunato, Vigna, Ernesto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotides - administration & dosage Adult Anticancer Section / Novel Insights from Clinical Practice Arabinonucleosides - administration & dosage Bone Marrow - pathology Cyclophosphamide - administration & dosage Disease-Free Survival Female Fusion Proteins, bcr-abl - genetics Graft vs Host Disease - etiology Humans Imidazoles - adverse effects Imidazoles - therapeutic use Immunophenotyping Mutation Neoplasm, Residual Philadelphia Chromosome Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Prednisone - administration & dosage Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Pyridazines - adverse effects Pyridazines - therapeutic use Recurrence Salvage Therapy Transplantation, Homologous
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