In IgA Nephropathy, Glomerulosclerosis Is Associated with Increased Urinary CD80 Excretion and Urokinase-Type Plasminogen Activator Receptor-Positive Podocyturia
Background: Podocyturia may determine the evolution to podocytopenia, glomerulosclerosis, and renal failure. According to the Oxford classification of IgA nephropathy (IgAN), the S1 lesion describes glomerulosclerosis. Urokinase-type plasminogen activator receptor (uPAR) participates in podocyte att...
Gespeichert in:
| Veröffentlicht in: | Nephron extra 2017-05, Vol.7 (2), p.52-61 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 61 |
|---|---|
| container_issue | 2 |
| container_start_page | 52 |
| container_title | Nephron extra |
| container_volume | 7 |
| creator | Trimarchi, Hernán Canzonieri, Romina Schiel, Amalia Costales-Collaguazo, Cristian Stern, Aníbal Paulero, Matías Rengel, Tatiana Andrews, José Iotti, Alejandro Forrester, Mariano Lombi, Fernando Pomeranz, Vanesa Iriarte, Romina Muryan, Alexis Zotta, Elsa |
| description | Background: Podocyturia may determine the evolution to podocytopenia, glomerulosclerosis, and renal failure. According to the Oxford classification of IgA nephropathy (IgAN), the S1 lesion describes glomerulosclerosis. Urokinase-type plasminogen activator receptor (uPAR) participates in podocyte attachment, while CD80 increases in glomerulosclerosis. We measured uPAR-positive urinary podocytes and urinary CD80 (uCD80) in controls and in IgAN subjects with M1E0S0T0 and M1E0S1T0 Oxford scores to assess a potential association between podocyturia, inflammation, and glomerulosclerosis. Methods: The groups were as follows: controls (G1), n = 20 and IgAN group (G2), n = 39, subdivided into M1E0S0T0 (G2A), n = 21 and M1E0S1T0 (G2B), n = 18. Among the included variables, we determined uPAR-positive podocytes/gram of urinary creatinine (gUrCr) and uCD80 ng/gUrCr. Biopsies with interstitial fibrosis and tubular atrophy |
| doi_str_mv | 10.1159/000473888 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_karger_primary_473888</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1911202865</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-673d1484989f7a2f53e9e8acd02a7dc2bd1b0011788176eb8390b6b37cd2f49c3</originalsourceid><addsrcrecordid>eNptkU1r3DAQhkVpaUKSQ--lCHppoG4l-Uu-FJbNNjGEbSjJWcjyeFeNLTmSnGR_Tv9pFTY1KfSk0byP3hnNIPSOki-U5tVXQkhWppzzV-iQFkWW5DmrXr-ID9CJ978iRgpCU169RQeMF6zISnaIftcG15sFXsO4dXaUYbv7jM97O4CbeutVD8567XHt8cJ7q7QM0OIHHba4NsqB9PF647SRboeXZ5zg1WNMB20NluZJsrdR9JBc70bAV730gzZ2AwYvVND3MliHf4KCMQbJVawVk5GzrVW7MDktj9GbTvYeTp7PI3TzfXW9vEguf5zXy8VlojKWhaQo05ZmPKt41ZWSdXkKFXCpWsJk2SrWtLQhhNKSc1oW0PC0Ik3RpKVqWZdVKj1C3_a-49QM0CowwclejE4P8W_CSi3-VYzeio29F3kcPynSaPDp2cDZuwl8EIP2CvpeGrCTF7SilJE4-jyip3tUxel6B91chhLxtFUxbzWyH172NZN_dxiB93vgVroNuBmY33_8r7xer_aEGNsu_QO3rrVj</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1911202865</pqid></control><display><type>article</type><title>In IgA Nephropathy, Glomerulosclerosis Is Associated with Increased Urinary CD80 Excretion and Urokinase-Type Plasminogen Activator Receptor-Positive Podocyturia</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>Karger Open Access</source><source>PubMed Central</source><creator>Trimarchi, Hernán ; Canzonieri, Romina ; Schiel, Amalia ; Costales-Collaguazo, Cristian ; Stern, Aníbal ; Paulero, Matías ; Rengel, Tatiana ; Andrews, José ; Iotti, Alejandro ; Forrester, Mariano ; Lombi, Fernando ; Pomeranz, Vanesa ; Iriarte, Romina ; Muryan, Alexis ; Zotta, Elsa</creator><creatorcontrib>Trimarchi, Hernán ; Canzonieri, Romina ; Schiel, Amalia ; Costales-Collaguazo, Cristian ; Stern, Aníbal ; Paulero, Matías ; Rengel, Tatiana ; Andrews, José ; Iotti, Alejandro ; Forrester, Mariano ; Lombi, Fernando ; Pomeranz, Vanesa ; Iriarte, Romina ; Muryan, Alexis ; Zotta, Elsa</creatorcontrib><description>Background: Podocyturia may determine the evolution to podocytopenia, glomerulosclerosis, and renal failure. According to the Oxford classification of IgA nephropathy (IgAN), the S1 lesion describes glomerulosclerosis. Urokinase-type plasminogen activator receptor (uPAR) participates in podocyte attachment, while CD80 increases in glomerulosclerosis. We measured uPAR-positive urinary podocytes and urinary CD80 (uCD80) in controls and in IgAN subjects with M1E0S0T0 and M1E0S1T0 Oxford scores to assess a potential association between podocyturia, inflammation, and glomerulosclerosis. Methods: The groups were as follows: controls (G1), n = 20 and IgAN group (G2), n = 39, subdivided into M1E0S0T0 (G2A), n = 21 and M1E0S1T0 (G2B), n = 18. Among the included variables, we determined uPAR-positive podocytes/gram of urinary creatinine (gUrCr) and uCD80 ng/gUrCr. Biopsies with interstitial fibrosis and tubular atrophy <10% were included. Results: Groups were not different in age and gender; urinary protein-creatinine (uP/C) ratio, Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation, uPAR-positive podocytes/gUrCr, and uCD80 were significantly increased in G2 versus G1. G2A and G2B were not different in age, gender, hypertension, and follow-up. G2B displayed significantly higher uP/C, uPAR-positive podocytes, uCD80, and lower CKD-EPI versus G2A. Strong significant correlations were encountered between uCD80 and podocyturia in G2A and G2B. However, when G1 was compared to G2A and G2B separately, the differences with respect to uP/C, uPAR-positive podocytes, and podocyturia were significantly stronger versus G2B than versus G2A. Conclusions: IgAN presents elevated uCD80 excretion and uPAR-positive podocyturia, while CD80 correlates with podocyturia. Glomerulosclerosis (S1) at the time of biopsy is associated with higher uP/C, lower renal function, increased uPAR-positive podocyturia, and CD80 excretion, and is independent of M1. In IgAN, uPAR may participate in podocyte detachment.</description><identifier>ISSN: 1664-5529</identifier><identifier>EISSN: 1664-5529</identifier><identifier>DOI: 10.1159/000473888</identifier><identifier>PMID: 28626472</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Original Paper</subject><ispartof>Nephron extra, 2017-05, Vol.7 (2), p.52-61</ispartof><rights>2017 The Author(s). Published by S. Karger AG, Basel</rights><rights>Copyright © 2017 by S. Karger AG, Basel 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-673d1484989f7a2f53e9e8acd02a7dc2bd1b0011788176eb8390b6b37cd2f49c3</citedby><cites>FETCH-LOGICAL-c424t-673d1484989f7a2f53e9e8acd02a7dc2bd1b0011788176eb8390b6b37cd2f49c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473063/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473063/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27626,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28626472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trimarchi, Hernán</creatorcontrib><creatorcontrib>Canzonieri, Romina</creatorcontrib><creatorcontrib>Schiel, Amalia</creatorcontrib><creatorcontrib>Costales-Collaguazo, Cristian</creatorcontrib><creatorcontrib>Stern, Aníbal</creatorcontrib><creatorcontrib>Paulero, Matías</creatorcontrib><creatorcontrib>Rengel, Tatiana</creatorcontrib><creatorcontrib>Andrews, José</creatorcontrib><creatorcontrib>Iotti, Alejandro</creatorcontrib><creatorcontrib>Forrester, Mariano</creatorcontrib><creatorcontrib>Lombi, Fernando</creatorcontrib><creatorcontrib>Pomeranz, Vanesa</creatorcontrib><creatorcontrib>Iriarte, Romina</creatorcontrib><creatorcontrib>Muryan, Alexis</creatorcontrib><creatorcontrib>Zotta, Elsa</creatorcontrib><title>In IgA Nephropathy, Glomerulosclerosis Is Associated with Increased Urinary CD80 Excretion and Urokinase-Type Plasminogen Activator Receptor-Positive Podocyturia</title><title>Nephron extra</title><addtitle>Nephron Extra</addtitle><description>Background: Podocyturia may determine the evolution to podocytopenia, glomerulosclerosis, and renal failure. According to the Oxford classification of IgA nephropathy (IgAN), the S1 lesion describes glomerulosclerosis. Urokinase-type plasminogen activator receptor (uPAR) participates in podocyte attachment, while CD80 increases in glomerulosclerosis. We measured uPAR-positive urinary podocytes and urinary CD80 (uCD80) in controls and in IgAN subjects with M1E0S0T0 and M1E0S1T0 Oxford scores to assess a potential association between podocyturia, inflammation, and glomerulosclerosis. Methods: The groups were as follows: controls (G1), n = 20 and IgAN group (G2), n = 39, subdivided into M1E0S0T0 (G2A), n = 21 and M1E0S1T0 (G2B), n = 18. Among the included variables, we determined uPAR-positive podocytes/gram of urinary creatinine (gUrCr) and uCD80 ng/gUrCr. Biopsies with interstitial fibrosis and tubular atrophy <10% were included. Results: Groups were not different in age and gender; urinary protein-creatinine (uP/C) ratio, Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation, uPAR-positive podocytes/gUrCr, and uCD80 were significantly increased in G2 versus G1. G2A and G2B were not different in age, gender, hypertension, and follow-up. G2B displayed significantly higher uP/C, uPAR-positive podocytes, uCD80, and lower CKD-EPI versus G2A. Strong significant correlations were encountered between uCD80 and podocyturia in G2A and G2B. However, when G1 was compared to G2A and G2B separately, the differences with respect to uP/C, uPAR-positive podocytes, and podocyturia were significantly stronger versus G2B than versus G2A. Conclusions: IgAN presents elevated uCD80 excretion and uPAR-positive podocyturia, while CD80 correlates with podocyturia. Glomerulosclerosis (S1) at the time of biopsy is associated with higher uP/C, lower renal function, increased uPAR-positive podocyturia, and CD80 excretion, and is independent of M1. In IgAN, uPAR may participate in podocyte detachment.</description><subject>Original Paper</subject><issn>1664-5529</issn><issn>1664-5529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><recordid>eNptkU1r3DAQhkVpaUKSQ--lCHppoG4l-Uu-FJbNNjGEbSjJWcjyeFeNLTmSnGR_Tv9pFTY1KfSk0byP3hnNIPSOki-U5tVXQkhWppzzV-iQFkWW5DmrXr-ID9CJ978iRgpCU169RQeMF6zISnaIftcG15sFXsO4dXaUYbv7jM97O4CbeutVD8567XHt8cJ7q7QM0OIHHba4NsqB9PF647SRboeXZ5zg1WNMB20NluZJsrdR9JBc70bAV730gzZ2AwYvVND3MliHf4KCMQbJVawVk5GzrVW7MDktj9GbTvYeTp7PI3TzfXW9vEguf5zXy8VlojKWhaQo05ZmPKt41ZWSdXkKFXCpWsJk2SrWtLQhhNKSc1oW0PC0Ik3RpKVqWZdVKj1C3_a-49QM0CowwclejE4P8W_CSi3-VYzeio29F3kcPynSaPDp2cDZuwl8EIP2CvpeGrCTF7SilJE4-jyip3tUxel6B91chhLxtFUxbzWyH172NZN_dxiB93vgVroNuBmY33_8r7xer_aEGNsu_QO3rrVj</recordid><startdate>20170516</startdate><enddate>20170516</enddate><creator>Trimarchi, Hernán</creator><creator>Canzonieri, Romina</creator><creator>Schiel, Amalia</creator><creator>Costales-Collaguazo, Cristian</creator><creator>Stern, Aníbal</creator><creator>Paulero, Matías</creator><creator>Rengel, Tatiana</creator><creator>Andrews, José</creator><creator>Iotti, Alejandro</creator><creator>Forrester, Mariano</creator><creator>Lombi, Fernando</creator><creator>Pomeranz, Vanesa</creator><creator>Iriarte, Romina</creator><creator>Muryan, Alexis</creator><creator>Zotta, Elsa</creator><general>S. Karger AG</general><scope>M--</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170516</creationdate><title>In IgA Nephropathy, Glomerulosclerosis Is Associated with Increased Urinary CD80 Excretion and Urokinase-Type Plasminogen Activator Receptor-Positive Podocyturia</title><author>Trimarchi, Hernán ; Canzonieri, Romina ; Schiel, Amalia ; Costales-Collaguazo, Cristian ; Stern, Aníbal ; Paulero, Matías ; Rengel, Tatiana ; Andrews, José ; Iotti, Alejandro ; Forrester, Mariano ; Lombi, Fernando ; Pomeranz, Vanesa ; Iriarte, Romina ; Muryan, Alexis ; Zotta, Elsa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-673d1484989f7a2f53e9e8acd02a7dc2bd1b0011788176eb8390b6b37cd2f49c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trimarchi, Hernán</creatorcontrib><creatorcontrib>Canzonieri, Romina</creatorcontrib><creatorcontrib>Schiel, Amalia</creatorcontrib><creatorcontrib>Costales-Collaguazo, Cristian</creatorcontrib><creatorcontrib>Stern, Aníbal</creatorcontrib><creatorcontrib>Paulero, Matías</creatorcontrib><creatorcontrib>Rengel, Tatiana</creatorcontrib><creatorcontrib>Andrews, José</creatorcontrib><creatorcontrib>Iotti, Alejandro</creatorcontrib><creatorcontrib>Forrester, Mariano</creatorcontrib><creatorcontrib>Lombi, Fernando</creatorcontrib><creatorcontrib>Pomeranz, Vanesa</creatorcontrib><creatorcontrib>Iriarte, Romina</creatorcontrib><creatorcontrib>Muryan, Alexis</creatorcontrib><creatorcontrib>Zotta, Elsa</creatorcontrib><collection>Karger Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nephron extra</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trimarchi, Hernán</au><au>Canzonieri, Romina</au><au>Schiel, Amalia</au><au>Costales-Collaguazo, Cristian</au><au>Stern, Aníbal</au><au>Paulero, Matías</au><au>Rengel, Tatiana</au><au>Andrews, José</au><au>Iotti, Alejandro</au><au>Forrester, Mariano</au><au>Lombi, Fernando</au><au>Pomeranz, Vanesa</au><au>Iriarte, Romina</au><au>Muryan, Alexis</au><au>Zotta, Elsa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In IgA Nephropathy, Glomerulosclerosis Is Associated with Increased Urinary CD80 Excretion and Urokinase-Type Plasminogen Activator Receptor-Positive Podocyturia</atitle><jtitle>Nephron extra</jtitle><addtitle>Nephron Extra</addtitle><date>2017-05-16</date><risdate>2017</risdate><volume>7</volume><issue>2</issue><spage>52</spage><epage>61</epage><pages>52-61</pages><issn>1664-5529</issn><eissn>1664-5529</eissn><abstract>Background: Podocyturia may determine the evolution to podocytopenia, glomerulosclerosis, and renal failure. According to the Oxford classification of IgA nephropathy (IgAN), the S1 lesion describes glomerulosclerosis. Urokinase-type plasminogen activator receptor (uPAR) participates in podocyte attachment, while CD80 increases in glomerulosclerosis. We measured uPAR-positive urinary podocytes and urinary CD80 (uCD80) in controls and in IgAN subjects with M1E0S0T0 and M1E0S1T0 Oxford scores to assess a potential association between podocyturia, inflammation, and glomerulosclerosis. Methods: The groups were as follows: controls (G1), n = 20 and IgAN group (G2), n = 39, subdivided into M1E0S0T0 (G2A), n = 21 and M1E0S1T0 (G2B), n = 18. Among the included variables, we determined uPAR-positive podocytes/gram of urinary creatinine (gUrCr) and uCD80 ng/gUrCr. Biopsies with interstitial fibrosis and tubular atrophy <10% were included. Results: Groups were not different in age and gender; urinary protein-creatinine (uP/C) ratio, Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation, uPAR-positive podocytes/gUrCr, and uCD80 were significantly increased in G2 versus G1. G2A and G2B were not different in age, gender, hypertension, and follow-up. G2B displayed significantly higher uP/C, uPAR-positive podocytes, uCD80, and lower CKD-EPI versus G2A. Strong significant correlations were encountered between uCD80 and podocyturia in G2A and G2B. However, when G1 was compared to G2A and G2B separately, the differences with respect to uP/C, uPAR-positive podocytes, and podocyturia were significantly stronger versus G2B than versus G2A. Conclusions: IgAN presents elevated uCD80 excretion and uPAR-positive podocyturia, while CD80 correlates with podocyturia. Glomerulosclerosis (S1) at the time of biopsy is associated with higher uP/C, lower renal function, increased uPAR-positive podocyturia, and CD80 excretion, and is independent of M1. In IgAN, uPAR may participate in podocyte detachment.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>28626472</pmid><doi>10.1159/000473888</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1664-5529 |
| ispartof | Nephron extra, 2017-05, Vol.7 (2), p.52-61 |
| issn | 1664-5529 1664-5529 |
| language | eng |
| recordid | cdi_karger_primary_473888 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Karger Open Access; PubMed Central |
| subjects | Original Paper |
| title | In IgA Nephropathy, Glomerulosclerosis Is Associated with Increased Urinary CD80 Excretion and Urokinase-Type Plasminogen Activator Receptor-Positive Podocyturia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T04%3A56%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_karge&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20IgA%20Nephropathy,%20Glomerulosclerosis%20Is%20Associated%20with%20Increased%20Urinary%20CD80%20Excretion%20and%20Urokinase-Type%20Plasminogen%20Activator%20Receptor-Positive%20Podocyturia&rft.jtitle=Nephron%20extra&rft.au=Trimarchi,%20Hern%C3%A1n&rft.date=2017-05-16&rft.volume=7&rft.issue=2&rft.spage=52&rft.epage=61&rft.pages=52-61&rft.issn=1664-5529&rft.eissn=1664-5529&rft_id=info:doi/10.1159/000473888&rft_dat=%3Cproquest_karge%3E1911202865%3C/proquest_karge%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1911202865&rft_id=info:pmid/28626472&rfr_iscdi=true |