Role of Organic Anion Transporters in the Uptake of Protein-Bound Uremic Toxins by Human Endothelial Cells and Monocyte Chemoattractant Protein-1 Expression

Organic anion transporters (OATs) are involved in the uptake of uremic toxins such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS), which play a role in endothelial dysfunction in patients with chronic kidney diseases (CKD). In this study, we investigated the role of OAT1 and OAT3 in the uptake o...

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Veröffentlicht in:	Journal of vascular research 2017-01, Vol.54 (3), p.170-179
Hauptverfasser:	Favretto, Giane, Souza, Lauro M., Gregório, Paulo C., Cunha, Regiane S., Maciel, Rayana A.P., Sassaki, Guilherme L., Toledo, Maria G., Pecoits-Filho, Roberto, Souza, Wesley M., Stinghen, Andréa E.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport Cell Line Cell Survival - drug effects Chemokine CCL2 - metabolism Cresols - metabolism Cresols - toxicity Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Humans Indican - metabolism Indican - toxicity Organic Anion Transport Protein 1 - antagonists & inhibitors Organic Anion Transport Protein 1 - metabolism Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors Organic Anion Transporters, Sodium-Independent - metabolism Probenecid - pharmacology Research Paper Sulfuric Acid Esters - metabolism Sulfuric Acid Esters - toxicity Time Factors Up-Regulation Uremia - metabolism Uremia - pathology
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