Knockdown of PD-L1 in Human Gastric Cancer Cells Inhibits Tumor Progression and Improves the Cytotoxic Sensitivity to CIK Therapy

Background/Abstract: PD-L1 has been an important target of cancer immunotherapy. We have showed that in human gastric cancer tissues, over-expression of PD-L1 was significantly associated with cancer progression and patients’ postoperative prognoses. However, as of now, how PD-L1 regulates the biolo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular physiology and biochemistry 2017, Vol.41 (3), p.907-920
Hauptverfasser:	Li, Jing, Chen, Lujun, Xiong, Yuqi, Zheng, Xiao, Xie, Quanqin, Zhou, Qi, Shi, Liangrong, Wu, Changping, Jiang, Jingting, Wang, Haitao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Apoptosis - immunology B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - genetics B7-H1 Antigen - immunology Breast cancer Cancer progression Cancer therapies Cell cycle Cell Cycle - genetics Cell Cycle - immunology Cell Line, Tumor Cell Movement - genetics Cell Movement - immunology Cell Survival - genetics Cell Survival - immunology Cytokine-Induced Killer Cells - cytology Cytokine-Induced Killer Cells - drug effects Cytokine-Induced Killer Cells - immunology Cytotoxicity Cytotoxicity, Immunologic Diffusion Chambers, Culture Female Gastric cancer Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Immunohistochemistry Immunotherapy - methods Interleukin-2 - pharmacology Lymphocyte Activation - drug effects Metastasis Mice Mice, Nude Neoplasm Transplantation Original Paper PD-L1 Polymerase chain reaction Proteins RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNAi Signal Transduction Skin cancer Stomach Neoplasms - genetics Stomach Neoplasms - immunology Stomach Neoplasms - pathology Stomach Neoplasms - therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!