Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1

Background: Reversible acetylcholinesterase inhibitors are used in Alzheimer disease therapy. However, tacrine and its derivatives have severe side effects. Derivatives of the tacrine analogue 7-methoxytacrine (MEOTA) are less toxic. Methods: We evaluated new derivatives of 7-MEOTA (2 homodimers lin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Dementia and geriatric cognitive disorders 2017-02, Vol.43 (1-2), p.45-58
Hauptverfasser:	Kristofikova, Zdenka, Ricny, Jan, Soukup, Ondrej, Korabecny, Jan, Nepovimova, Eugenie, Kuca, Kamil, Ripova, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Alzheimer's disease Amyloid beta-Peptides - drug effects Animals Anti-Alzheimer's disease agents Brain Cation Transport Proteins - drug effects Cerebral Cortex - drug effects Cholesterol - metabolism Choline Choline - metabolism Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - pharmacology Enzyme inhibitors Hippocampus - drug effects Hippocampus - metabolism Male Membrane Fluidity - drug effects Membrane Microdomains - drug effects Original Research Article Quaternary Ammonium Compounds - chemistry Quaternary Ammonium Compounds - pharmacology Rats Rats, Wistar Stereoisomerism Synaptosomes - drug effects Synaptosomes - metabolism Tacrine - analogs & derivatives Tacrine - chemical synthesis Tacrine - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!