Feasibility of Extracted-Overlay Fusion Imaging for Intraoperative Treatment Evaluation of Radiofrequency Ablation for Hepatocellular Carcinoma
Background and Aims: Extracted-overlay fusion imaging is a novel computed tomography/magnetic resonance-ultrasonography (CT/MR-US) imaging technique in which a target tumor with a virtual ablative margin is extracted from CT/MR volume data and synchronously overlaid on US images. We investigated the...
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| Veröffentlicht in: | Liver cancer (Basel ) 2016-10, Vol.5 (4), p.269-279 |
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| creator | Makino, Yuki Imai, Yasuharu Igura, Takumi Kogita, Sachiyo Sawai, Yoshiyuki Fukuda, Kazuto Iwamoto, Takayuki Okabe, Junya Takamura, Manabu Fujita, Norihiko Hori, Masatoshi Takehara, Tetsuo Kudo, Masatoshi Murakami, Takamichi |
| description | Background and Aims: Extracted-overlay fusion imaging is a novel computed tomography/magnetic resonance-ultrasonography (CT/MR-US) imaging technique in which a target tumor with a virtual ablative margin is extracted from CT/MR volume data and synchronously overlaid on US images. We investigated the applicability of the technique to intraoperative evaluation of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). Methods: This retrospective study analyzed 85 HCCs treated with RFA using extracted-overlay fusion imaging for guidance and evaluation. To perform RFA, an electrode was inserted targeting the tumor and a virtual 5-mm ablative margin overlaid on the US image. Following ablation, contrast-enhanced US (CEUS) was performed to assess the ablative margin, and the minimal ablative margins were categorized into three groups: (I) margin |
| doi_str_mv | 10.1159/000449338 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_karger_primary_449338</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1835533214</sourcerecordid><originalsourceid>FETCH-LOGICAL-c490t-9d058253bef5a9b087dfd780634cd8bb24d2c87469e29d181f1323c247da41483</originalsourceid><addsrcrecordid>eNptkU-LEzEYh4Mobln34F0k4MU9jOZvk1yEpbS7hcKCrOeQSTI1OjMZk5liP4Vf2ZSpRcFT4H0fnjc_fgC8xugDxlx9RAgxpiiVz8ACL5es4pzT52BBCOUVFopfgZucvxUMSYSEEi_BFRFCYqzUAvzaeJNDHdowHmFs4PrnmIwdvaseDz615gg3Uw6xh9vO7EO_h01McNsXKA4-mTEcPHxK3oyd70e4Pph2KsPCF9dn40Jskv8x-d4e4V3dzquT4sEPZozWt-3UmgRXJtnQx868Ai8a02Z_c36vwZfN-mn1UO0e77eru11lmUJjpRziknBa-4YbVSMpXOOEREvKrJN1TZgjVgq2VJ4ohyVuMCXUEiacYZhJeg0-zd5hqjvvrD9FavWQQmfSUUcT9L-bPnzV-3jQHAkuMSmC92dBiiVgHnUX8imP6X2cssaSlh4owaygtzNqU8w5-eZyBiN96lBfOizs27__dSH_NFaAdzPw3aS9Txdgt13NCj24plBv_kudr_wGA-evOg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1835533214</pqid></control><display><type>article</type><title>Feasibility of Extracted-Overlay Fusion Imaging for Intraoperative Treatment Evaluation of Radiofrequency Ablation for Hepatocellular Carcinoma</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Makino, Yuki ; Imai, Yasuharu ; Igura, Takumi ; Kogita, Sachiyo ; Sawai, Yoshiyuki ; Fukuda, Kazuto ; Iwamoto, Takayuki ; Okabe, Junya ; Takamura, Manabu ; Fujita, Norihiko ; Hori, Masatoshi ; Takehara, Tetsuo ; Kudo, Masatoshi ; Murakami, Takamichi</creator><creatorcontrib>Makino, Yuki ; Imai, Yasuharu ; Igura, Takumi ; Kogita, Sachiyo ; Sawai, Yoshiyuki ; Fukuda, Kazuto ; Iwamoto, Takayuki ; Okabe, Junya ; Takamura, Manabu ; Fujita, Norihiko ; Hori, Masatoshi ; Takehara, Tetsuo ; Kudo, Masatoshi ; Murakami, Takamichi</creatorcontrib><description>Background and Aims: Extracted-overlay fusion imaging is a novel computed tomography/magnetic resonance-ultrasonography (CT/MR-US) imaging technique in which a target tumor with a virtual ablative margin is extracted from CT/MR volume data and synchronously overlaid on US images. We investigated the applicability of the technique to intraoperative evaluation of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). Methods: This retrospective study analyzed 85 HCCs treated with RFA using extracted-overlay fusion imaging for guidance and evaluation. To perform RFA, an electrode was inserted targeting the tumor and a virtual 5-mm ablative margin overlaid on the US image. Following ablation, contrast-enhanced US (CEUS) was performed to assess the ablative margin, and the minimal ablative margins were categorized into three groups: (I) margin <0 mm (protrusion), (II) margin 0 to <5 mm, and (III) margin ≥5 mm. Margin assessment was based on the positional relationship between the overlaid tumor plus margin and the perfusion defect of the ablation zone. Tumors in group I underwent repeat ablation until they were in groups II or III. The final classifications were compared with those obtained by retrospectively created fusion images of pre- and post-RFA CT or MR imaging (CT-CT/MR-MR fusion imaging). Results: Treatment evaluation was impossible using CEUS in six HCCs because the tumors were located far below the body surface. Of the remaining 79 HCCs, the categorizations of minimal ablative margins between CEUS extracted-overlay fusion imaging and CT-CT/MR-MR fusion imaging were in agreement for 72 tumors (91.1%) (Cohen's quadratic-weighted kappa coefficient 0.66, good agreement, p<0.01). Conclusions: Extracted-overlay fusion imaging combined with CEUS is feasible for the evaluation of RFA and enables intraoperative treatment evaluation without the need to perform contrast-enhanced CT.</description><identifier>ISSN: 2235-1795</identifier><identifier>EISSN: 1664-5553</identifier><identifier>DOI: 10.1159/000449338</identifier><identifier>PMID: 27781199</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Original Paper</subject><ispartof>Liver cancer (Basel ), 2016-10, Vol.5 (4), p.269-279</ispartof><rights>2016 S. Karger AG, Basel</rights><rights>Copyright © 2016 by S. Karger AG, Basel 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-9d058253bef5a9b087dfd780634cd8bb24d2c87469e29d181f1323c247da41483</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075812/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075812/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27781199$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Makino, Yuki</creatorcontrib><creatorcontrib>Imai, Yasuharu</creatorcontrib><creatorcontrib>Igura, Takumi</creatorcontrib><creatorcontrib>Kogita, Sachiyo</creatorcontrib><creatorcontrib>Sawai, Yoshiyuki</creatorcontrib><creatorcontrib>Fukuda, Kazuto</creatorcontrib><creatorcontrib>Iwamoto, Takayuki</creatorcontrib><creatorcontrib>Okabe, Junya</creatorcontrib><creatorcontrib>Takamura, Manabu</creatorcontrib><creatorcontrib>Fujita, Norihiko</creatorcontrib><creatorcontrib>Hori, Masatoshi</creatorcontrib><creatorcontrib>Takehara, Tetsuo</creatorcontrib><creatorcontrib>Kudo, Masatoshi</creatorcontrib><creatorcontrib>Murakami, Takamichi</creatorcontrib><title>Feasibility of Extracted-Overlay Fusion Imaging for Intraoperative Treatment Evaluation of Radiofrequency Ablation for Hepatocellular Carcinoma</title><title>Liver cancer (Basel )</title><addtitle>Liver Cancer</addtitle><description>Background and Aims: Extracted-overlay fusion imaging is a novel computed tomography/magnetic resonance-ultrasonography (CT/MR-US) imaging technique in which a target tumor with a virtual ablative margin is extracted from CT/MR volume data and synchronously overlaid on US images. We investigated the applicability of the technique to intraoperative evaluation of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). Methods: This retrospective study analyzed 85 HCCs treated with RFA using extracted-overlay fusion imaging for guidance and evaluation. To perform RFA, an electrode was inserted targeting the tumor and a virtual 5-mm ablative margin overlaid on the US image. Following ablation, contrast-enhanced US (CEUS) was performed to assess the ablative margin, and the minimal ablative margins were categorized into three groups: (I) margin <0 mm (protrusion), (II) margin 0 to <5 mm, and (III) margin ≥5 mm. Margin assessment was based on the positional relationship between the overlaid tumor plus margin and the perfusion defect of the ablation zone. Tumors in group I underwent repeat ablation until they were in groups II or III. The final classifications were compared with those obtained by retrospectively created fusion images of pre- and post-RFA CT or MR imaging (CT-CT/MR-MR fusion imaging). Results: Treatment evaluation was impossible using CEUS in six HCCs because the tumors were located far below the body surface. Of the remaining 79 HCCs, the categorizations of minimal ablative margins between CEUS extracted-overlay fusion imaging and CT-CT/MR-MR fusion imaging were in agreement for 72 tumors (91.1%) (Cohen's quadratic-weighted kappa coefficient 0.66, good agreement, p<0.01). Conclusions: Extracted-overlay fusion imaging combined with CEUS is feasible for the evaluation of RFA and enables intraoperative treatment evaluation without the need to perform contrast-enhanced CT.</description><subject>Original Paper</subject><issn>2235-1795</issn><issn>1664-5553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNptkU-LEzEYh4Mobln34F0k4MU9jOZvk1yEpbS7hcKCrOeQSTI1OjMZk5liP4Vf2ZSpRcFT4H0fnjc_fgC8xugDxlx9RAgxpiiVz8ACL5es4pzT52BBCOUVFopfgZucvxUMSYSEEi_BFRFCYqzUAvzaeJNDHdowHmFs4PrnmIwdvaseDz615gg3Uw6xh9vO7EO_h01McNsXKA4-mTEcPHxK3oyd70e4Pph2KsPCF9dn40Jskv8x-d4e4V3dzquT4sEPZozWt-3UmgRXJtnQx868Ai8a02Z_c36vwZfN-mn1UO0e77eru11lmUJjpRziknBa-4YbVSMpXOOEREvKrJN1TZgjVgq2VJ4ohyVuMCXUEiacYZhJeg0-zd5hqjvvrD9FavWQQmfSUUcT9L-bPnzV-3jQHAkuMSmC92dBiiVgHnUX8imP6X2cssaSlh4owaygtzNqU8w5-eZyBiN96lBfOizs27__dSH_NFaAdzPw3aS9Txdgt13NCj24plBv_kudr_wGA-evOg</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Makino, Yuki</creator><creator>Imai, Yasuharu</creator><creator>Igura, Takumi</creator><creator>Kogita, Sachiyo</creator><creator>Sawai, Yoshiyuki</creator><creator>Fukuda, Kazuto</creator><creator>Iwamoto, Takayuki</creator><creator>Okabe, Junya</creator><creator>Takamura, Manabu</creator><creator>Fujita, Norihiko</creator><creator>Hori, Masatoshi</creator><creator>Takehara, Tetsuo</creator><creator>Kudo, Masatoshi</creator><creator>Murakami, Takamichi</creator><general>S. Karger AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201610</creationdate><title>Feasibility of Extracted-Overlay Fusion Imaging for Intraoperative Treatment Evaluation of Radiofrequency Ablation for Hepatocellular Carcinoma</title><author>Makino, Yuki ; Imai, Yasuharu ; Igura, Takumi ; Kogita, Sachiyo ; Sawai, Yoshiyuki ; Fukuda, Kazuto ; Iwamoto, Takayuki ; Okabe, Junya ; Takamura, Manabu ; Fujita, Norihiko ; Hori, Masatoshi ; Takehara, Tetsuo ; Kudo, Masatoshi ; Murakami, Takamichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-9d058253bef5a9b087dfd780634cd8bb24d2c87469e29d181f1323c247da41483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Makino, Yuki</creatorcontrib><creatorcontrib>Imai, Yasuharu</creatorcontrib><creatorcontrib>Igura, Takumi</creatorcontrib><creatorcontrib>Kogita, Sachiyo</creatorcontrib><creatorcontrib>Sawai, Yoshiyuki</creatorcontrib><creatorcontrib>Fukuda, Kazuto</creatorcontrib><creatorcontrib>Iwamoto, Takayuki</creatorcontrib><creatorcontrib>Okabe, Junya</creatorcontrib><creatorcontrib>Takamura, Manabu</creatorcontrib><creatorcontrib>Fujita, Norihiko</creatorcontrib><creatorcontrib>Hori, Masatoshi</creatorcontrib><creatorcontrib>Takehara, Tetsuo</creatorcontrib><creatorcontrib>Kudo, Masatoshi</creatorcontrib><creatorcontrib>Murakami, Takamichi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Liver cancer (Basel )</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Makino, Yuki</au><au>Imai, Yasuharu</au><au>Igura, Takumi</au><au>Kogita, Sachiyo</au><au>Sawai, Yoshiyuki</au><au>Fukuda, Kazuto</au><au>Iwamoto, Takayuki</au><au>Okabe, Junya</au><au>Takamura, Manabu</au><au>Fujita, Norihiko</au><au>Hori, Masatoshi</au><au>Takehara, Tetsuo</au><au>Kudo, Masatoshi</au><au>Murakami, Takamichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feasibility of Extracted-Overlay Fusion Imaging for Intraoperative Treatment Evaluation of Radiofrequency Ablation for Hepatocellular Carcinoma</atitle><jtitle>Liver cancer (Basel )</jtitle><addtitle>Liver Cancer</addtitle><date>2016-10</date><risdate>2016</risdate><volume>5</volume><issue>4</issue><spage>269</spage><epage>279</epage><pages>269-279</pages><issn>2235-1795</issn><eissn>1664-5553</eissn><abstract>Background and Aims: Extracted-overlay fusion imaging is a novel computed tomography/magnetic resonance-ultrasonography (CT/MR-US) imaging technique in which a target tumor with a virtual ablative margin is extracted from CT/MR volume data and synchronously overlaid on US images. We investigated the applicability of the technique to intraoperative evaluation of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). Methods: This retrospective study analyzed 85 HCCs treated with RFA using extracted-overlay fusion imaging for guidance and evaluation. To perform RFA, an electrode was inserted targeting the tumor and a virtual 5-mm ablative margin overlaid on the US image. Following ablation, contrast-enhanced US (CEUS) was performed to assess the ablative margin, and the minimal ablative margins were categorized into three groups: (I) margin <0 mm (protrusion), (II) margin 0 to <5 mm, and (III) margin ≥5 mm. Margin assessment was based on the positional relationship between the overlaid tumor plus margin and the perfusion defect of the ablation zone. Tumors in group I underwent repeat ablation until they were in groups II or III. The final classifications were compared with those obtained by retrospectively created fusion images of pre- and post-RFA CT or MR imaging (CT-CT/MR-MR fusion imaging). Results: Treatment evaluation was impossible using CEUS in six HCCs because the tumors were located far below the body surface. Of the remaining 79 HCCs, the categorizations of minimal ablative margins between CEUS extracted-overlay fusion imaging and CT-CT/MR-MR fusion imaging were in agreement for 72 tumors (91.1%) (Cohen's quadratic-weighted kappa coefficient 0.66, good agreement, p<0.01). Conclusions: Extracted-overlay fusion imaging combined with CEUS is feasible for the evaluation of RFA and enables intraoperative treatment evaluation without the need to perform contrast-enhanced CT.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>27781199</pmid><doi>10.1159/000449338</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Original Paper |
| title | Feasibility of Extracted-Overlay Fusion Imaging for Intraoperative Treatment Evaluation of Radiofrequency Ablation for Hepatocellular Carcinoma |
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