Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis
A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Su...
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| Veröffentlicht in: | Case Reports in Gastroenterology 2016-10, Vol.10 (3), p.596-599 |
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| creator | Gomez, Gustavo Umar, Shifa Bilal, Mohammad Strahotin, Cristina Clarke, Kofi |
| description | A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Supportive care, broad-spectrum antibiotic, and single dose of filgrastim was given on day 5 of admission due to persistently low absolute neutrophil count and fevers. The cell lines recovered, fever resolved and the patient made a complete clinical recovery. Clinicians should be aware of this potential life-threatening inflixmab side effect previously unreported in adults with UC. |
| doi_str_mv | 10.1159/000448071 |
| format | Article |
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There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Supportive care, broad-spectrum antibiotic, and single dose of filgrastim was given on day 5 of admission due to persistently low absolute neutrophil count and fevers. The cell lines recovered, fever resolved and the patient made a complete clinical recovery. 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Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1784-212X</orcidid></search><sort><creationdate>20161018</creationdate><title>Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis</title><author>Gomez, Gustavo ; Umar, Shifa ; Bilal, Mohammad ; Strahotin, Cristina ; Clarke, Kofi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4391-4874dd6e7495d359e4e68503f103354e8454e502d69c861d3e658f0616aad08a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Case studies</topic><topic>Causes of</topic><topic>Complications and side effects</topic><topic>Diagnosis</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Febrile neutropenia</topic><topic>Infliximab</topic><topic>Neutropenia</topic><topic>Single Case</topic><topic>Thrombocytopenia</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomez, Gustavo</creatorcontrib><creatorcontrib>Umar, Shifa</creatorcontrib><creatorcontrib>Bilal, Mohammad</creatorcontrib><creatorcontrib>Strahotin, Cristina</creatorcontrib><creatorcontrib>Clarke, Kofi</creatorcontrib><collection>Karger Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Case Reports in Gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomez, Gustavo</au><au>Umar, Shifa</au><au>Bilal, Mohammad</au><au>Strahotin, Cristina</au><au>Clarke, Kofi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis</atitle><jtitle>Case Reports in Gastroenterology</jtitle><addtitle>Case Rep Gastroenterol</addtitle><date>2016-10-18</date><risdate>2016</risdate><volume>10</volume><issue>3</issue><spage>596</spage><epage>599</epage><pages>596-599</pages><issn>1662-0631</issn><eissn>1662-0631</eissn><abstract>A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Supportive care, broad-spectrum antibiotic, and single dose of filgrastim was given on day 5 of admission due to persistently low absolute neutrophil count and fevers. The cell lines recovered, fever resolved and the patient made a complete clinical recovery. Clinicians should be aware of this potential life-threatening inflixmab side effect previously unreported in adults with UC.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>27920647</pmid><doi>10.1159/000448071</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-1784-212X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Karger Open Access; PubMed Central |
| subjects | Case studies Causes of Complications and side effects Diagnosis Dosage and administration Drug therapy Febrile neutropenia Infliximab Neutropenia Single Case Thrombocytopenia Ulcerative colitis |
| title | Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis |
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