Sulforaphane Prevents Neuronal Apoptosis and Memory Impairment in Diabetic Rats

Background/Aims: To explore the effects of sulforaphane (SFN) on neuronal apoptosis in hippocampus and memory impairment in diabetic rats. Methods: Thirty male rats were randomly divided into normal control, diabetic model and SFN treatment groups (N = 10 in each group). Streptozotocin (STZ) was app...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular physiology and biochemistry 2016-01, Vol.39 (3), p.901-907
Hauptverfasser:	Wang, Gengyin, Fang, Hui, Zhen, Yanfeng, Xu, Gang, Tian, Jinli, Zhang, Yazhong, Zhang, Dandan, Zhang, Guyue, Xu, Jing, Zhang, Zhiyue, Qiu, Mingyue, Ma, Yijia, Zhang, Hongrui, Zhang, Xinxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticarcinogenic Agents - pharmacology Apoptosis Apoptosis - drug effects Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Caspase 3 - genetics Caspase 3 - metabolism Cognitive Dysfunction - physiopathology Cognitive Dysfunction - prevention & control Diabetes Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - physiopathology Drug Repositioning Gene Expression - drug effects Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Hypoglycemic Agents - pharmacology Isothiocyanates - pharmacology Male Maze Learning - drug effects Memory - drug effects Memory impairment Myeloid Cell Leukemia Sequence 1 Protein - genetics Myeloid Cell Leukemia Sequence 1 Protein - metabolism Nerve Growth Factor - genetics Nerve Growth Factor - metabolism Neurons - drug effects Neurons - metabolism Neurons - pathology Original Paper Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Streptozocin Sulforaphane
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!