Sulforaphane Prevents Neuronal Apoptosis and Memory Impairment in Diabetic Rats
Background/Aims: To explore the effects of sulforaphane (SFN) on neuronal apoptosis in hippocampus and memory impairment in diabetic rats. Methods: Thirty male rats were randomly divided into normal control, diabetic model and SFN treatment groups (N = 10 in each group). Streptozotocin (STZ) was app...
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| Veröffentlicht in: | Cellular physiology and biochemistry 2016-01, Vol.39 (3), p.901-907 |
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| creator | Wang, Gengyin Fang, Hui Zhen, Yanfeng Xu, Gang Tian, Jinli Zhang, Yazhong Zhang, Dandan Zhang, Guyue Xu, Jing Zhang, Zhiyue Qiu, Mingyue Ma, Yijia Zhang, Hongrui Zhang, Xinxin |
| description | Background/Aims: To explore the effects of sulforaphane (SFN) on neuronal apoptosis in hippocampus and memory impairment in diabetic rats. Methods: Thirty male rats were randomly divided into normal control, diabetic model and SFN treatment groups (N = 10 in each group). Streptozotocin (STZ) was applied to establish diabetic model. Water Morris maze task was applied to test learning and memory. Tunel assaying was used to detect apoptosis in hippocampus. The expressions of Caspase-3 and myeloid cell leukemia 1(MCL-1) were detected by western blotting. Neurotrophic factor levels and AKT/GSK3β pathway were also detected. Results: Compared with normal control, learning and memory were apparently impaired, with up-regulation of Caspase-3 and down-regulation of MCL-1 in diabetic rats. Apoptotic neurons were also found in CA1 region after diabetic modeling. By contrast, SFN treatment prevented the memory impairment, decreased the apoptosis of hippocampal neurons. SFN also attenuated the abnormal expression of Caspase-3 and MCL-1 in diabetic model. Mechanically, SFN treatment reversed diabetic modeling-induced decrease of p-Akt, p-GSK3β, NGF and BDNF expressions. Conclusion: SFN could prevent the memory impairment and apoptosis of hippocampal neurons in diabetic rat. The possible mechanism was related to the regulation of neurotropic factors and Akt/GSK3β pathway. |
| doi_str_mv | 10.1159/000447799 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_karge</sourceid><recordid>TN_cdi_karger_primary_447799</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_77120452fa4e416599af08296afe977f</doaj_id><sourcerecordid>27497670</sourcerecordid><originalsourceid>FETCH-LOGICAL-c501t-22f9cc9abaa759c6cd68e9d1dfa3e20a7109434221325e7298993523f849a1923</originalsourceid><addsrcrecordid>eNptkD1PwzAQhi0EolAY2BGyxMQQsB0nzo2lfFUqtOJjjq6JXVKaOLJTpP57AoFMTD7fPffo9BJywtkl5xFcMcakVApghxxwKXgASiW7bc14FCSQqAE59H7F2q8CsU8GQklQsWIHZPayWRvrsH7HStO505-6ajx90htnK1zTUW3rxvrCU6xy-qhL67Z0UtZYuLIlaVHRmwIXuiky-oyNPyJ7BtdeH_--Q_J2d_s6fgims_vJeDQNsojxJhDCQJYBLhBVBFmc5XGiIee5wVALhoozkKEUgoci0kpAAhBGIjSJBOQgwiGZdN7c4iqtXVGi26YWi_SnYd0yRdcetdapUlwwGQmDUkseRwBoWCIgRqPboEzruuhcmbPeO216H2fpd8BpH3DLnnVsvVmUOu_Jv0Rb4LQDPtAtteuBfv_83_F4ft0RaZ2b8AtosYkq</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Sulforaphane Prevents Neuronal Apoptosis and Memory Impairment in Diabetic Rats</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Karger Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Wang, Gengyin ; Fang, Hui ; Zhen, Yanfeng ; Xu, Gang ; Tian, Jinli ; Zhang, Yazhong ; Zhang, Dandan ; Zhang, Guyue ; Xu, Jing ; Zhang, Zhiyue ; Qiu, Mingyue ; Ma, Yijia ; Zhang, Hongrui ; Zhang, Xinxin</creator><creatorcontrib>Wang, Gengyin ; Fang, Hui ; Zhen, Yanfeng ; Xu, Gang ; Tian, Jinli ; Zhang, Yazhong ; Zhang, Dandan ; Zhang, Guyue ; Xu, Jing ; Zhang, Zhiyue ; Qiu, Mingyue ; Ma, Yijia ; Zhang, Hongrui ; Zhang, Xinxin</creatorcontrib><description>Background/Aims: To explore the effects of sulforaphane (SFN) on neuronal apoptosis in hippocampus and memory impairment in diabetic rats. Methods: Thirty male rats were randomly divided into normal control, diabetic model and SFN treatment groups (N = 10 in each group). Streptozotocin (STZ) was applied to establish diabetic model. Water Morris maze task was applied to test learning and memory. Tunel assaying was used to detect apoptosis in hippocampus. The expressions of Caspase-3 and myeloid cell leukemia 1(MCL-1) were detected by western blotting. Neurotrophic factor levels and AKT/GSK3β pathway were also detected. Results: Compared with normal control, learning and memory were apparently impaired, with up-regulation of Caspase-3 and down-regulation of MCL-1 in diabetic rats. Apoptotic neurons were also found in CA1 region after diabetic modeling. By contrast, SFN treatment prevented the memory impairment, decreased the apoptosis of hippocampal neurons. SFN also attenuated the abnormal expression of Caspase-3 and MCL-1 in diabetic model. Mechanically, SFN treatment reversed diabetic modeling-induced decrease of p-Akt, p-GSK3β, NGF and BDNF expressions. Conclusion: SFN could prevent the memory impairment and apoptosis of hippocampal neurons in diabetic rat. The possible mechanism was related to the regulation of neurotropic factors and Akt/GSK3β pathway.</description><identifier>ISSN: 1015-8987</identifier><identifier>EISSN: 1421-9778</identifier><identifier>DOI: 10.1159/000447799</identifier><identifier>PMID: 27497670</identifier><language>eng</language><publisher>Basel, Switzerland: Cell Physiol Biochem Press GmbH & Co KG</publisher><subject>Animals ; Anticarcinogenic Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Brain-Derived Neurotrophic Factor - genetics ; Brain-Derived Neurotrophic Factor - metabolism ; Caspase 3 - genetics ; Caspase 3 - metabolism ; Cognitive Dysfunction - physiopathology ; Cognitive Dysfunction - prevention & control ; Diabetes ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - genetics ; Diabetes Mellitus, Experimental - physiopathology ; Drug Repositioning ; Gene Expression - drug effects ; Glycogen Synthase Kinase 3 beta - genetics ; Glycogen Synthase Kinase 3 beta - metabolism ; Hippocampus - drug effects ; Hippocampus - metabolism ; Hippocampus - pathology ; Hypoglycemic Agents - pharmacology ; Isothiocyanates - pharmacology ; Male ; Maze Learning - drug effects ; Memory - drug effects ; Memory impairment ; Myeloid Cell Leukemia Sequence 1 Protein - genetics ; Myeloid Cell Leukemia Sequence 1 Protein - metabolism ; Nerve Growth Factor - genetics ; Nerve Growth Factor - metabolism ; Neurons - drug effects ; Neurons - metabolism ; Neurons - pathology ; Original Paper ; Proto-Oncogene Proteins c-akt - genetics ; Proto-Oncogene Proteins c-akt - metabolism ; Rats ; Rats, Sprague-Dawley ; Streptozocin ; Sulforaphane</subject><ispartof>Cellular physiology and biochemistry, 2016-01, Vol.39 (3), p.901-907</ispartof><rights>2016 The Author(s) Published by S. Karger AG, Basel</rights><rights>2016 The Author(s) Published by S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-22f9cc9abaa759c6cd68e9d1dfa3e20a7109434221325e7298993523f849a1923</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,2102,27635,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27497670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Gengyin</creatorcontrib><creatorcontrib>Fang, Hui</creatorcontrib><creatorcontrib>Zhen, Yanfeng</creatorcontrib><creatorcontrib>Xu, Gang</creatorcontrib><creatorcontrib>Tian, Jinli</creatorcontrib><creatorcontrib>Zhang, Yazhong</creatorcontrib><creatorcontrib>Zhang, Dandan</creatorcontrib><creatorcontrib>Zhang, Guyue</creatorcontrib><creatorcontrib>Xu, Jing</creatorcontrib><creatorcontrib>Zhang, Zhiyue</creatorcontrib><creatorcontrib>Qiu, Mingyue</creatorcontrib><creatorcontrib>Ma, Yijia</creatorcontrib><creatorcontrib>Zhang, Hongrui</creatorcontrib><creatorcontrib>Zhang, Xinxin</creatorcontrib><title>Sulforaphane Prevents Neuronal Apoptosis and Memory Impairment in Diabetic Rats</title><title>Cellular physiology and biochemistry</title><addtitle>Cell Physiol Biochem</addtitle><description>Background/Aims: To explore the effects of sulforaphane (SFN) on neuronal apoptosis in hippocampus and memory impairment in diabetic rats. Methods: Thirty male rats were randomly divided into normal control, diabetic model and SFN treatment groups (N = 10 in each group). Streptozotocin (STZ) was applied to establish diabetic model. Water Morris maze task was applied to test learning and memory. Tunel assaying was used to detect apoptosis in hippocampus. The expressions of Caspase-3 and myeloid cell leukemia 1(MCL-1) were detected by western blotting. Neurotrophic factor levels and AKT/GSK3β pathway were also detected. Results: Compared with normal control, learning and memory were apparently impaired, with up-regulation of Caspase-3 and down-regulation of MCL-1 in diabetic rats. Apoptotic neurons were also found in CA1 region after diabetic modeling. By contrast, SFN treatment prevented the memory impairment, decreased the apoptosis of hippocampal neurons. SFN also attenuated the abnormal expression of Caspase-3 and MCL-1 in diabetic model. Mechanically, SFN treatment reversed diabetic modeling-induced decrease of p-Akt, p-GSK3β, NGF and BDNF expressions. Conclusion: SFN could prevent the memory impairment and apoptosis of hippocampal neurons in diabetic rat. The possible mechanism was related to the regulation of neurotropic factors and Akt/GSK3β pathway.</description><subject>Animals</subject><subject>Anticarcinogenic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Caspase 3 - genetics</subject><subject>Caspase 3 - metabolism</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Cognitive Dysfunction - prevention & control</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - genetics</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Drug Repositioning</subject><subject>Gene Expression - drug effects</subject><subject>Glycogen Synthase Kinase 3 beta - genetics</subject><subject>Glycogen Synthase Kinase 3 beta - metabolism</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - pathology</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Isothiocyanates - pharmacology</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Memory - drug effects</subject><subject>Memory impairment</subject><subject>Myeloid Cell Leukemia Sequence 1 Protein - genetics</subject><subject>Myeloid Cell Leukemia Sequence 1 Protein - metabolism</subject><subject>Nerve Growth Factor - genetics</subject><subject>Nerve Growth Factor - metabolism</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>Original Paper</subject><subject>Proto-Oncogene Proteins c-akt - genetics</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Streptozocin</subject><subject>Sulforaphane</subject><issn>1015-8987</issn><issn>1421-9778</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNptkD1PwzAQhi0EolAY2BGyxMQQsB0nzo2lfFUqtOJjjq6JXVKaOLJTpP57AoFMTD7fPffo9BJywtkl5xFcMcakVApghxxwKXgASiW7bc14FCSQqAE59H7F2q8CsU8GQklQsWIHZPayWRvrsH7HStO505-6ajx90htnK1zTUW3rxvrCU6xy-qhL67Z0UtZYuLIlaVHRmwIXuiky-oyNPyJ7BtdeH_--Q_J2d_s6fgims_vJeDQNsojxJhDCQJYBLhBVBFmc5XGiIee5wVALhoozkKEUgoci0kpAAhBGIjSJBOQgwiGZdN7c4iqtXVGi26YWi_SnYd0yRdcetdapUlwwGQmDUkseRwBoWCIgRqPboEzruuhcmbPeO216H2fpd8BpH3DLnnVsvVmUOu_Jv0Rb4LQDPtAtteuBfv_83_F4ft0RaZ2b8AtosYkq</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Wang, Gengyin</creator><creator>Fang, Hui</creator><creator>Zhen, Yanfeng</creator><creator>Xu, Gang</creator><creator>Tian, Jinli</creator><creator>Zhang, Yazhong</creator><creator>Zhang, Dandan</creator><creator>Zhang, Guyue</creator><creator>Xu, Jing</creator><creator>Zhang, Zhiyue</creator><creator>Qiu, Mingyue</creator><creator>Ma, Yijia</creator><creator>Zhang, Hongrui</creator><creator>Zhang, Xinxin</creator><general>Cell Physiol Biochem Press GmbH & Co KG</general><scope>M--</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>DOA</scope></search><sort><creationdate>20160101</creationdate><title>Sulforaphane Prevents Neuronal Apoptosis and Memory Impairment in Diabetic Rats</title><author>Wang, Gengyin ; Fang, Hui ; Zhen, Yanfeng ; Xu, Gang ; Tian, Jinli ; Zhang, Yazhong ; Zhang, Dandan ; Zhang, Guyue ; Xu, Jing ; Zhang, Zhiyue ; Qiu, Mingyue ; Ma, Yijia ; Zhang, Hongrui ; Zhang, Xinxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-22f9cc9abaa759c6cd68e9d1dfa3e20a7109434221325e7298993523f849a1923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Anticarcinogenic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Caspase 3 - genetics</topic><topic>Caspase 3 - metabolism</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Cognitive Dysfunction - prevention & control</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - genetics</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Drug Repositioning</topic><topic>Gene Expression - drug effects</topic><topic>Glycogen Synthase Kinase 3 beta - genetics</topic><topic>Glycogen Synthase Kinase 3 beta - metabolism</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - pathology</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Isothiocyanates - pharmacology</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Memory - drug effects</topic><topic>Memory impairment</topic><topic>Myeloid Cell Leukemia Sequence 1 Protein - genetics</topic><topic>Myeloid Cell Leukemia Sequence 1 Protein - metabolism</topic><topic>Nerve Growth Factor - genetics</topic><topic>Nerve Growth Factor - metabolism</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Neurons - pathology</topic><topic>Original Paper</topic><topic>Proto-Oncogene Proteins c-akt - genetics</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Streptozocin</topic><topic>Sulforaphane</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Gengyin</creatorcontrib><creatorcontrib>Fang, Hui</creatorcontrib><creatorcontrib>Zhen, Yanfeng</creatorcontrib><creatorcontrib>Xu, Gang</creatorcontrib><creatorcontrib>Tian, Jinli</creatorcontrib><creatorcontrib>Zhang, Yazhong</creatorcontrib><creatorcontrib>Zhang, Dandan</creatorcontrib><creatorcontrib>Zhang, Guyue</creatorcontrib><creatorcontrib>Xu, Jing</creatorcontrib><creatorcontrib>Zhang, Zhiyue</creatorcontrib><creatorcontrib>Qiu, Mingyue</creatorcontrib><creatorcontrib>Ma, Yijia</creatorcontrib><creatorcontrib>Zhang, Hongrui</creatorcontrib><creatorcontrib>Zhang, Xinxin</creatorcontrib><collection>Karger Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cellular physiology and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Gengyin</au><au>Fang, Hui</au><au>Zhen, Yanfeng</au><au>Xu, Gang</au><au>Tian, Jinli</au><au>Zhang, Yazhong</au><au>Zhang, Dandan</au><au>Zhang, Guyue</au><au>Xu, Jing</au><au>Zhang, Zhiyue</au><au>Qiu, Mingyue</au><au>Ma, Yijia</au><au>Zhang, Hongrui</au><au>Zhang, Xinxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sulforaphane Prevents Neuronal Apoptosis and Memory Impairment in Diabetic Rats</atitle><jtitle>Cellular physiology and biochemistry</jtitle><addtitle>Cell Physiol Biochem</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>39</volume><issue>3</issue><spage>901</spage><epage>907</epage><pages>901-907</pages><issn>1015-8987</issn><eissn>1421-9778</eissn><abstract>Background/Aims: To explore the effects of sulforaphane (SFN) on neuronal apoptosis in hippocampus and memory impairment in diabetic rats. Methods: Thirty male rats were randomly divided into normal control, diabetic model and SFN treatment groups (N = 10 in each group). Streptozotocin (STZ) was applied to establish diabetic model. Water Morris maze task was applied to test learning and memory. Tunel assaying was used to detect apoptosis in hippocampus. The expressions of Caspase-3 and myeloid cell leukemia 1(MCL-1) were detected by western blotting. Neurotrophic factor levels and AKT/GSK3β pathway were also detected. Results: Compared with normal control, learning and memory were apparently impaired, with up-regulation of Caspase-3 and down-regulation of MCL-1 in diabetic rats. Apoptotic neurons were also found in CA1 region after diabetic modeling. By contrast, SFN treatment prevented the memory impairment, decreased the apoptosis of hippocampal neurons. SFN also attenuated the abnormal expression of Caspase-3 and MCL-1 in diabetic model. Mechanically, SFN treatment reversed diabetic modeling-induced decrease of p-Akt, p-GSK3β, NGF and BDNF expressions. Conclusion: SFN could prevent the memory impairment and apoptosis of hippocampal neurons in diabetic rat. The possible mechanism was related to the regulation of neurotropic factors and Akt/GSK3β pathway.</abstract><cop>Basel, Switzerland</cop><pub>Cell Physiol Biochem Press GmbH & Co KG</pub><pmid>27497670</pmid><doi>10.1159/000447799</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anticarcinogenic Agents - pharmacology Apoptosis Apoptosis - drug effects Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Caspase 3 - genetics Caspase 3 - metabolism Cognitive Dysfunction - physiopathology Cognitive Dysfunction - prevention & control Diabetes Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - physiopathology Drug Repositioning Gene Expression - drug effects Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Hypoglycemic Agents - pharmacology Isothiocyanates - pharmacology Male Maze Learning - drug effects Memory - drug effects Memory impairment Myeloid Cell Leukemia Sequence 1 Protein - genetics Myeloid Cell Leukemia Sequence 1 Protein - metabolism Nerve Growth Factor - genetics Nerve Growth Factor - metabolism Neurons - drug effects Neurons - metabolism Neurons - pathology Original Paper Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Streptozocin Sulforaphane |
| title | Sulforaphane Prevents Neuronal Apoptosis and Memory Impairment in Diabetic Rats |
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