Evidence for the Inhibition by Temozolomide, an Imidazotetrazine Family Alkylator, of Intermediate-Conductance Ca2+-Activated K+ Channels in Glioma Cells

Abstract Background: Temozolomide (TMZ), an oral alkylator of the imidazotetrazine family, is used to treat glioma. Whether this drug has any ionic effects in glioma cells remains largely unclear. Methods: With the aid of patch-clamp technology, we investigated the effects of TMZ on the ionic curren...

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Veröffentlicht in:	Cellular physiology and biochemistry 2016-01, Vol.38 (5), p.1727-1742
Hauptverfasser:	Yeh, Poh-Shiow, Wu, Shyh-Jong, Hung, Te-Yu, Huang, Yan-Ming, Hsu, Chia-Wei, Sze, Chun-I, Hsieh, Yi-Jung, Huang, Chin-Wei, Wu, Sheng-Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - toxicity Benzimidazoles - pharmacology Cell Line, Tumor Dacarbazine - analogs & derivatives Dacarbazine - toxicity DNA Damage - drug effects Glioma Glioma cell Humans Intermediate-conductance Ca2+-activated K+ channel Intermediate-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors Intermediate-Conductance Calcium-Activated Potassium Channels - genetics Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism Ionomycin - pharmacology K+ current Large-Conductance Calcium-Activated Potassium Channels - metabolism Membrane potential Membrane Potentials - drug effects Original Paper Patch-Clamp Techniques Potassium Channels, Inwardly Rectifying - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Small Interfering - metabolism Temozolomide
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