Escin Increases the Survival Rate of LPS-Induced Septic Mice Through Inhibition of HMGB1 Release from Macrophages

Background: Previous studies have described the effects of Escin on improving the survival rate of endotoxemic animals. The purpose of this study was to explore the molecular mechanisms of this potentially beneficial treatment. Methods: First, the survival rate of endotoxemic mice was monitored for...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2015-01, Vol.36 (4), p.1577-1586
Hauptverfasser:	Cheng, Yajun, Wang, Hongrui, Mao, Min, Liang, Chao, Zhang, Yu, Yang, Deijun, Wei, Ziran, Gao, Shunxiang, Hu, Bo, Wang, Lianghua, Cai, Qingping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - therapeutic use Care and treatment Cell Line Cell Survival - drug effects Cytokines - blood Cytokines - immunology Endotoxemia - blood Endotoxemia - drug therapy Endotoxemia - immunology Escin Escin - therapeutic use Health aspects High motility group box 1(HMGB1) HMGB1 Protein - blood HMGB1 Protein - immunology Lipopolysaccharides - immunology Macrophages Macrophages - drug effects Macrophages - immunology Male Mice Mice, Inbred BALB C NF-κB Original Paper Saponins Sepsis Sepsis - blood Sepsis - drug therapy Sepsis - immunology Survival Rate
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