PRDX6 Protects ARPE-19 Cells from Oxidative Damage via PI3K/AKT Signaling

Background/Aims: Oxidative stress that damages cells of the retinal pigment epithelium (RPE) can cause the development of hereditary retinal disease (HRD). PRDX6, which is a member of the PRDX family, is essential for removing metabolic free radicals from the body. However, the effect of PRDX6 on ox...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2015-08, Vol.36 (6), p.2217-2228
Hauptverfasser:	Zha, Xu, Wu, Guojiu, Zhao, Xueying, Zhou, Liqiong, Zhang, Hong, Li, Jinghua, Ma, Linkun, Zhang, Yuanping
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis ARPE-19 Cell Death - drug effects Cell Death - radiation effects Cell Line Cellular signal transduction Cytoprotection - drug effects Cytoprotection - genetics Cytoprotection - radiation effects Gene Expression Regulation - drug effects Gene Expression Regulation - radiation effects Health aspects Humans Hydrogen Peroxide - pharmacology Light Original Paper Oxidative stress Oxidative Stress - drug effects Oxidative Stress - radiation effects Peroxiredoxin VI - genetics Peroxiredoxin VI - metabolism Phosphatidylinositol 3-Kinases - metabolism PI3K/AKT signaling pathway PRDX6 Proto-Oncogene Proteins c-akt - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects
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