Extracorporeal Virus Elimination for the Treatment of Severe Ebola Virus Disease - First Experience with Lectin Affinity Plasmapheresis
Therapeutic options for Ebola virus disease (EVD) are currently limited to (1) best supportive care, and (2) evolving virus-specific therapies, resulting from decades of analyzing one of the world's deadliest diseases. Supportive care ranges from oral or intravenous rehydration therapy and anti...
Gespeichert in:
| Veröffentlicht in: | Blood purification 2014-01, Vol.38 (3-4), p.286-291 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 291 |
|---|---|
| container_issue | 3-4 |
| container_start_page | 286 |
| container_title | Blood purification |
| container_volume | 38 |
| creator | Büttner, Stefan Koch, Benjamin Dolnik, Olga Eickmann, Markus Freiwald, Tilo Rudolf, Sarah Engel, Jürgen Becker, Stephan Ronco, Claudio Geiger, Helmut |
| description | Therapeutic options for Ebola virus disease (EVD) are currently limited to (1) best supportive care, and (2) evolving virus-specific therapies, resulting from decades of analyzing one of the world's deadliest diseases. Supportive care ranges from oral or intravenous rehydration therapy and anti-emetics in developing countries to much more extensive life-support interventions in resource-rich countries. Current EVD-specific therapies attempt to either interfere with the earliest steps of viral replication or to elicit a strong immune response against the virus. An entirely new approach is the extracorporeal elimination of viruses and viral glycoproteins by lectin affinity plasmapheresis. Herein, we report for the first time the successful and safe use of lectin affinity plasmapheresis in a patient with severe Ebola virus disease. |
| doi_str_mv | 10.1159/000375229 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_karger_primary_375229</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1655256151</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-3e2c34171d386d8a1c2b1bb8b1bd0e0dc165f825f156750459d029bf4ca6bc3f3</originalsourceid><addsrcrecordid>eNo9kE1P4zAQhi0Egm7hwH218pE9BDxOnCZHVAK7UiWQKFwjxxlT7yZxsF0-fgF_G6OWXmYO87yvNA8hp8DOAUR5wRhLZ4Lzco9MIOOQlLNU7JMJ4yJNBMuLI_LD-3-MQZaL8pAccZHPcpaJCfmo3oKTyrrROpQdfTRu7WnVmd4MMhg7UG0dDSuky3gPPQ6BWk3v8QUd0qqxndxmroxH6ZEm9No4H2j1NqIzOCikryas6AJVMAO91NoMJrzTu076Xo6r2OONPyYHWnYeT7Z7Sh6uq-X8T7K4vfk7v1wkKgMISYpcpRnMoE2LvC0kKN5A0xRxtAxZqyAXuuBCQ_xQxA_LlvGy0ZmSeaNSnU7J2aZ3dPZ5jT7UvfEKu04OaNe-jnkR7YCAiP7eoMpZ7x3qenSml-69BlZ_ea933iP7a1u7bnpsd-S36Aj83AD_pXtCtwO2-U8BQ4fI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1655256151</pqid></control><display><type>article</type><title>Extracorporeal Virus Elimination for the Treatment of Severe Ebola Virus Disease - First Experience with Lectin Affinity Plasmapheresis</title><source>Karger Journals</source><source>MEDLINE</source><creator>Büttner, Stefan ; Koch, Benjamin ; Dolnik, Olga ; Eickmann, Markus ; Freiwald, Tilo ; Rudolf, Sarah ; Engel, Jürgen ; Becker, Stephan ; Ronco, Claudio ; Geiger, Helmut</creator><creatorcontrib>Büttner, Stefan ; Koch, Benjamin ; Dolnik, Olga ; Eickmann, Markus ; Freiwald, Tilo ; Rudolf, Sarah ; Engel, Jürgen ; Becker, Stephan ; Ronco, Claudio ; Geiger, Helmut</creatorcontrib><description>Therapeutic options for Ebola virus disease (EVD) are currently limited to (1) best supportive care, and (2) evolving virus-specific therapies, resulting from decades of analyzing one of the world's deadliest diseases. Supportive care ranges from oral or intravenous rehydration therapy and anti-emetics in developing countries to much more extensive life-support interventions in resource-rich countries. Current EVD-specific therapies attempt to either interfere with the earliest steps of viral replication or to elicit a strong immune response against the virus. An entirely new approach is the extracorporeal elimination of viruses and viral glycoproteins by lectin affinity plasmapheresis. Herein, we report for the first time the successful and safe use of lectin affinity plasmapheresis in a patient with severe Ebola virus disease.</description><identifier>ISSN: 0253-5068</identifier><identifier>EISSN: 1421-9735</identifier><identifier>DOI: 10.1159/000375229</identifier><identifier>PMID: 25676045</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Adult ; Anticoagulants - therapeutic use ; Case Report ; Citrates ; Combined Modality Therapy ; Critical Care - methods ; Ebolavirus - isolation & purification ; Hemorrhagic Fever, Ebola - therapy ; Humans ; Kidneys, Artificial ; Male ; Mannose - chemistry ; Mannose-Binding Lectins - chemistry ; Plant Lectins - chemistry ; Plasmapheresis - methods ; Renal Dialysis - methods ; Uganda ; Viral Envelope Proteins - chemistry ; Viral Load ; Viremia - therapy</subject><ispartof>Blood purification, 2014-01, Vol.38 (3-4), p.286-291</ispartof><rights>2015 S. Karger AG, Basel</rights><rights>2015 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-3e2c34171d386d8a1c2b1bb8b1bd0e0dc165f825f156750459d029bf4ca6bc3f3</citedby><cites>FETCH-LOGICAL-c411t-3e2c34171d386d8a1c2b1bb8b1bd0e0dc165f825f156750459d029bf4ca6bc3f3</cites><orcidid>0000-0002-3253-8396 ; 0000-0002-9085-2455 ; 0000-0002-6697-4065</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25676045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Büttner, Stefan</creatorcontrib><creatorcontrib>Koch, Benjamin</creatorcontrib><creatorcontrib>Dolnik, Olga</creatorcontrib><creatorcontrib>Eickmann, Markus</creatorcontrib><creatorcontrib>Freiwald, Tilo</creatorcontrib><creatorcontrib>Rudolf, Sarah</creatorcontrib><creatorcontrib>Engel, Jürgen</creatorcontrib><creatorcontrib>Becker, Stephan</creatorcontrib><creatorcontrib>Ronco, Claudio</creatorcontrib><creatorcontrib>Geiger, Helmut</creatorcontrib><title>Extracorporeal Virus Elimination for the Treatment of Severe Ebola Virus Disease - First Experience with Lectin Affinity Plasmapheresis</title><title>Blood purification</title><addtitle>Blood Purif</addtitle><description>Therapeutic options for Ebola virus disease (EVD) are currently limited to (1) best supportive care, and (2) evolving virus-specific therapies, resulting from decades of analyzing one of the world's deadliest diseases. Supportive care ranges from oral or intravenous rehydration therapy and anti-emetics in developing countries to much more extensive life-support interventions in resource-rich countries. Current EVD-specific therapies attempt to either interfere with the earliest steps of viral replication or to elicit a strong immune response against the virus. An entirely new approach is the extracorporeal elimination of viruses and viral glycoproteins by lectin affinity plasmapheresis. Herein, we report for the first time the successful and safe use of lectin affinity plasmapheresis in a patient with severe Ebola virus disease.</description><subject>Adult</subject><subject>Anticoagulants - therapeutic use</subject><subject>Case Report</subject><subject>Citrates</subject><subject>Combined Modality Therapy</subject><subject>Critical Care - methods</subject><subject>Ebolavirus - isolation & purification</subject><subject>Hemorrhagic Fever, Ebola - therapy</subject><subject>Humans</subject><subject>Kidneys, Artificial</subject><subject>Male</subject><subject>Mannose - chemistry</subject><subject>Mannose-Binding Lectins - chemistry</subject><subject>Plant Lectins - chemistry</subject><subject>Plasmapheresis - methods</subject><subject>Renal Dialysis - methods</subject><subject>Uganda</subject><subject>Viral Envelope Proteins - chemistry</subject><subject>Viral Load</subject><subject>Viremia - therapy</subject><issn>0253-5068</issn><issn>1421-9735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1P4zAQhi0Egm7hwH218pE9BDxOnCZHVAK7UiWQKFwjxxlT7yZxsF0-fgF_G6OWXmYO87yvNA8hp8DOAUR5wRhLZ4Lzco9MIOOQlLNU7JMJ4yJNBMuLI_LD-3-MQZaL8pAccZHPcpaJCfmo3oKTyrrROpQdfTRu7WnVmd4MMhg7UG0dDSuky3gPPQ6BWk3v8QUd0qqxndxmroxH6ZEm9No4H2j1NqIzOCikryas6AJVMAO91NoMJrzTu076Xo6r2OONPyYHWnYeT7Z7Sh6uq-X8T7K4vfk7v1wkKgMISYpcpRnMoE2LvC0kKN5A0xRxtAxZqyAXuuBCQ_xQxA_LlvGy0ZmSeaNSnU7J2aZ3dPZ5jT7UvfEKu04OaNe-jnkR7YCAiP7eoMpZ7x3qenSml-69BlZ_ea933iP7a1u7bnpsd-S36Aj83AD_pXtCtwO2-U8BQ4fI</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Büttner, Stefan</creator><creator>Koch, Benjamin</creator><creator>Dolnik, Olga</creator><creator>Eickmann, Markus</creator><creator>Freiwald, Tilo</creator><creator>Rudolf, Sarah</creator><creator>Engel, Jürgen</creator><creator>Becker, Stephan</creator><creator>Ronco, Claudio</creator><creator>Geiger, Helmut</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3253-8396</orcidid><orcidid>https://orcid.org/0000-0002-9085-2455</orcidid><orcidid>https://orcid.org/0000-0002-6697-4065</orcidid></search><sort><creationdate>20140101</creationdate><title>Extracorporeal Virus Elimination for the Treatment of Severe Ebola Virus Disease - First Experience with Lectin Affinity Plasmapheresis</title><author>Büttner, Stefan ; Koch, Benjamin ; Dolnik, Olga ; Eickmann, Markus ; Freiwald, Tilo ; Rudolf, Sarah ; Engel, Jürgen ; Becker, Stephan ; Ronco, Claudio ; Geiger, Helmut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-3e2c34171d386d8a1c2b1bb8b1bd0e0dc165f825f156750459d029bf4ca6bc3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Anticoagulants - therapeutic use</topic><topic>Case Report</topic><topic>Citrates</topic><topic>Combined Modality Therapy</topic><topic>Critical Care - methods</topic><topic>Ebolavirus - isolation & purification</topic><topic>Hemorrhagic Fever, Ebola - therapy</topic><topic>Humans</topic><topic>Kidneys, Artificial</topic><topic>Male</topic><topic>Mannose - chemistry</topic><topic>Mannose-Binding Lectins - chemistry</topic><topic>Plant Lectins - chemistry</topic><topic>Plasmapheresis - methods</topic><topic>Renal Dialysis - methods</topic><topic>Uganda</topic><topic>Viral Envelope Proteins - chemistry</topic><topic>Viral Load</topic><topic>Viremia - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Büttner, Stefan</creatorcontrib><creatorcontrib>Koch, Benjamin</creatorcontrib><creatorcontrib>Dolnik, Olga</creatorcontrib><creatorcontrib>Eickmann, Markus</creatorcontrib><creatorcontrib>Freiwald, Tilo</creatorcontrib><creatorcontrib>Rudolf, Sarah</creatorcontrib><creatorcontrib>Engel, Jürgen</creatorcontrib><creatorcontrib>Becker, Stephan</creatorcontrib><creatorcontrib>Ronco, Claudio</creatorcontrib><creatorcontrib>Geiger, Helmut</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood purification</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Büttner, Stefan</au><au>Koch, Benjamin</au><au>Dolnik, Olga</au><au>Eickmann, Markus</au><au>Freiwald, Tilo</au><au>Rudolf, Sarah</au><au>Engel, Jürgen</au><au>Becker, Stephan</au><au>Ronco, Claudio</au><au>Geiger, Helmut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extracorporeal Virus Elimination for the Treatment of Severe Ebola Virus Disease - First Experience with Lectin Affinity Plasmapheresis</atitle><jtitle>Blood purification</jtitle><addtitle>Blood Purif</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>38</volume><issue>3-4</issue><spage>286</spage><epage>291</epage><pages>286-291</pages><issn>0253-5068</issn><eissn>1421-9735</eissn><abstract>Therapeutic options for Ebola virus disease (EVD) are currently limited to (1) best supportive care, and (2) evolving virus-specific therapies, resulting from decades of analyzing one of the world's deadliest diseases. Supportive care ranges from oral or intravenous rehydration therapy and anti-emetics in developing countries to much more extensive life-support interventions in resource-rich countries. Current EVD-specific therapies attempt to either interfere with the earliest steps of viral replication or to elicit a strong immune response against the virus. An entirely new approach is the extracorporeal elimination of viruses and viral glycoproteins by lectin affinity plasmapheresis. Herein, we report for the first time the successful and safe use of lectin affinity plasmapheresis in a patient with severe Ebola virus disease.</abstract><cop>Basel, Switzerland</cop><pmid>25676045</pmid><doi>10.1159/000375229</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3253-8396</orcidid><orcidid>https://orcid.org/0000-0002-9085-2455</orcidid><orcidid>https://orcid.org/0000-0002-6697-4065</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0253-5068 |
| ispartof | Blood purification, 2014-01, Vol.38 (3-4), p.286-291 |
| issn | 0253-5068 1421-9735 |
| language | eng |
| recordid | cdi_karger_primary_375229 |
| source | Karger Journals; MEDLINE |
| subjects | Adult Anticoagulants - therapeutic use Case Report Citrates Combined Modality Therapy Critical Care - methods Ebolavirus - isolation & purification Hemorrhagic Fever, Ebola - therapy Humans Kidneys, Artificial Male Mannose - chemistry Mannose-Binding Lectins - chemistry Plant Lectins - chemistry Plasmapheresis - methods Renal Dialysis - methods Uganda Viral Envelope Proteins - chemistry Viral Load Viremia - therapy |
| title | Extracorporeal Virus Elimination for the Treatment of Severe Ebola Virus Disease - First Experience with Lectin Affinity Plasmapheresis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T01%3A27%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_karge&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Extracorporeal%20Virus%20Elimination%20for%20the%20Treatment%20of%20Severe%20Ebola%20Virus%20Disease%20-%20First%20Experience%20with%20Lectin%20Affinity%20Plasmapheresis&rft.jtitle=Blood%20purification&rft.au=B%C3%BCttner,%20Stefan&rft.date=2014-01-01&rft.volume=38&rft.issue=3-4&rft.spage=286&rft.epage=291&rft.pages=286-291&rft.issn=0253-5068&rft.eissn=1421-9735&rft_id=info:doi/10.1159/000375229&rft_dat=%3Cproquest_karge%3E1655256151%3C/proquest_karge%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1655256151&rft_id=info:pmid/25676045&rfr_iscdi=true |