Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels

Background: Huntington's disease (HD) is a late-onset fatal neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the gene coding for the protein huntingtin and is characterised by progressive motor, psychiatric and cognitive decline. We previously demonstrated that norma...

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Veröffentlicht in:	Neuro-degenerative diseases 2015-01, Vol.15 (2), p.93-108
Hauptverfasser:	Dallérac, Glenn M., Levasseur, Grégoire, Vatsavayai, Sarat C., Milnerwood, Austen J., Cummings, Damian M., Kraev, Igor, Huetz, Chloé, Evans, Karen A., Walters, Steve W., Rezaie, Payam, Cho, Yoon, Hirst, Mark C., Murphy, Kerry P.S.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biophysical Phenomena - genetics Brain - pathology Care and treatment Development and progression Disease Models, Animal DNA damage Dopamine - metabolism Dopaminergic mechanisms Dopaminergic Neurons - physiology Electric Stimulation Female Gene expression Gene Expression Regulation - genetics Genetic aspects Health aspects Humans Huntingtin Protein Huntington Disease - genetics Huntington Disease - pathology Huntington's disease In Vitro Techniques Ion channels Male Membrane Potentials - genetics Mice Mice, Transgenic Nerve Tissue Proteins - genetics Original Paper Small-Conductance Calcium-Activated Potassium Channels - metabolism Trinucleotide Repeat Expansion - genetics Tyrosine 3-Monooxygenase - metabolism
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