Modulation of Pulmonary Vascular Remodeling in Hypoxia: Role of 15-LOX-2/15-HETE-MAPKs Pathway

Background: We have previously shown that 15-hydroxyeicosatetraenoic acid (15-HETE) plays a critical role in pulmonary hypertension (PH)-associated vascular remodeling. However, the signaling mechanisms remain unclear. The purpose of this study was to investigate the role of 15-lipoxygenase-2 (15-LO...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2015-01, Vol.35 (6), p.2079-2097
Hauptverfasser:	Yu, Xiufeng, Li, Tingting, Liu, Xia, Yu, Hao, Hao, Zhongfei, Chen, Yingli, Zhang, Chen, Liu, Yumei, Li, Qian, Mao, Min, Zhu, Daling
Format:	Artikel
Sprache:	eng
Schlagworte:	15-hydrocyeiosatetraenoic acid Adult Animals Apoptosis - physiology Arachidonate 15-Lipoxygenase - metabolism Cell Cycle - physiology Cell Differentiation - physiology Cell Movement - physiology Cell Proliferation - physiology Cells, Cultured Cellular signal transduction Chemical properties Development and progression Diagnosis Extracellular Signal-Regulated MAP Kinases - metabolism Female Health aspects Humans Hydroxyeicosatetraenoic Acids - metabolism Hypoxia - metabolism Hypoxia - physiopathology Lung - metabolism Lung - physiology Male Mitogen-activated protein kinase Mitogen-activated protein kinases Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - physiology Original Paper p38 Mitogen-Activated Protein Kinases - metabolism Physiological aspects Pulmonary Artery - metabolism Pulmonary Artery - physiology Pulmonary hypertension Pulmonary hypertension vascular remodeling Rats Risk factors Signal Transduction - physiology Vascular Remodeling - physiology
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