Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review
Human skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo progressive loss and fragmentation, l...
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| Veröffentlicht in: | Gerontology (Basel) 2015-01, Vol.61 (5), p.427-434 |
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| creator | Quan, Taihao Fisher, Gary J. |
| description | Human skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo progressive loss and fragmentation, leading to thin and structurally weakened skin. Age-related alterations of collagen fibrils impairs skin structure and function and creates a tissue microenvironment that promotes age-related skin diseases, such as delayed wound healing and skin cancer development. This mini-review describes cellular mechanisms that give rise to self-perpetuating, collagen fibril fragmentation that creates an age-associated dermal microenvironment, which contributes to decline of human skin function. |
| doi_str_mv | 10.1159/000371708 |
| format | Article |
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The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo progressive loss and fragmentation, leading to thin and structurally weakened skin. Age-related alterations of collagen fibrils impairs skin structure and function and creates a tissue microenvironment that promotes age-related skin diseases, such as delayed wound healing and skin cancer development. This mini-review describes cellular mechanisms that give rise to self-perpetuating, collagen fibril fragmentation that creates an age-associated dermal microenvironment, which contributes to decline of human skin function.</description><identifier>ISSN: 0304-324X</identifier><identifier>EISSN: 1423-0003</identifier><identifier>DOI: 10.1159/000371708</identifier><identifier>PMID: 25660807</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Aging ; Aging - pathology ; Aging - physiology ; Cellular Microenvironment ; Collagen ; Connective Tissue - pathology ; Connective Tissue - physiopathology ; Cysteine-Rich Protein 61 - metabolism ; Dermatology ; Experimental Section / Mini-Review ; Extracellular matrix ; Extracellular Matrix - pathology ; Extracellular Matrix - physiology ; Gerontology ; Health aspects ; Humans ; Matrix Metalloproteinases - metabolism ; Models, Biological ; Physiological aspects ; Physiological research ; Proteins ; Signal Transduction ; Skin ; Skin aging ; Skin Aging - pathology ; Skin Aging - physiology ; Skin Diseases - etiology ; Transforming Growth Factor beta - metabolism</subject><ispartof>Gerontology (Basel), 2015-01, Vol.61 (5), p.427-434</ispartof><rights>2015 S. Karger AG, Basel</rights><rights>COPYRIGHT 2015 S. Karger AG</rights><rights>Copyright S. Karger AG Aug 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-70f1330779b3d16280c6407922a991e8407bcdaea79fa102e3a4f07bd048e8513</citedby><cites>FETCH-LOGICAL-c536t-70f1330779b3d16280c6407922a991e8407bcdaea79fa102e3a4f07bd048e8513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25660807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quan, Taihao</creatorcontrib><creatorcontrib>Fisher, Gary J.</creatorcontrib><title>Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review</title><title>Gerontology (Basel)</title><addtitle>Gerontology</addtitle><description>Human skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo progressive loss and fragmentation, leading to thin and structurally weakened skin. Age-related alterations of collagen fibrils impairs skin structure and function and creates a tissue microenvironment that promotes age-related skin diseases, such as delayed wound healing and skin cancer development. This mini-review describes cellular mechanisms that give rise to self-perpetuating, collagen fibril fragmentation that creates an age-associated dermal microenvironment, which contributes to decline of human skin function.</description><subject>Aging</subject><subject>Aging - pathology</subject><subject>Aging - physiology</subject><subject>Cellular Microenvironment</subject><subject>Collagen</subject><subject>Connective Tissue - pathology</subject><subject>Connective Tissue - physiopathology</subject><subject>Cysteine-Rich Protein 61 - metabolism</subject><subject>Dermatology</subject><subject>Experimental Section / Mini-Review</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - pathology</subject><subject>Extracellular Matrix - physiology</subject><subject>Gerontology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Matrix Metalloproteinases - metabolism</subject><subject>Models, Biological</subject><subject>Physiological aspects</subject><subject>Physiological research</subject><subject>Proteins</subject><subject>Signal Transduction</subject><subject>Skin</subject><subject>Skin aging</subject><subject>Skin Aging - pathology</subject><subject>Skin Aging - physiology</subject><subject>Skin Diseases - etiology</subject><subject>Transforming Growth Factor beta - metabolism</subject><issn>0304-324X</issn><issn>1423-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0cFu1DAQAFALgehSOHBHyBISgkNgHCdxwi0qhSK1QiogcYtmk0nWrWMX2ynt3-Nllz1w8mj8PB7NMPZcwDshyuY9AEglFNQP2EoUucy2iYdsBRKKTObFzyP2JISrlIRcwGN2lJdVBTWoFbu_dIa4G3k7UdaG4HqNkQbemkgeo3Y2bG_jhvhH8jMafnoXPfZkzGLQ8wuMXt_xC917R_ZWe2dnspFry8-WGS3_dp3CdtJ2-sDb5KzOLulW0--n7NGIJtCz_XnMfnw6_X5ylp1__fzlpD3P-lJWMVMwCilBqWYtB1HlNfRVAarJc2waQXWK1_2AhKoZUUBOEosx5QYoaqpLIY_Zm13dG-9-LRRiN-uw7R8tuSV0aW6qLIs0x0Rf_Uev3OJt6i4pqZomT0WTer1TExrqNoQmboIzy99hdW0lVWKVLBN8u4NpNiF4Grsbr2f0952Abru47rC4ZF_uv17WMw0H-W9TCbzYgWv0E_kD2L__A5VYmTU</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Quan, Taihao</creator><creator>Fisher, Gary J.</creator><general>S. 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Fisher, Gary J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-70f1330779b3d16280c6407922a991e8407bcdaea79fa102e3a4f07bd048e8513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aging</topic><topic>Aging - pathology</topic><topic>Aging - physiology</topic><topic>Cellular Microenvironment</topic><topic>Collagen</topic><topic>Connective Tissue - pathology</topic><topic>Connective Tissue - physiopathology</topic><topic>Cysteine-Rich Protein 61 - metabolism</topic><topic>Dermatology</topic><topic>Experimental Section / Mini-Review</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix - pathology</topic><topic>Extracellular Matrix - physiology</topic><topic>Gerontology</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Matrix Metalloproteinases - metabolism</topic><topic>Models, Biological</topic><topic>Physiological aspects</topic><topic>Physiological research</topic><topic>Proteins</topic><topic>Signal Transduction</topic><topic>Skin</topic><topic>Skin aging</topic><topic>Skin Aging - pathology</topic><topic>Skin Aging - physiology</topic><topic>Skin Diseases - etiology</topic><topic>Transforming Growth Factor beta - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quan, Taihao</creatorcontrib><creatorcontrib>Fisher, Gary J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Social Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Gerontology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quan, Taihao</au><au>Fisher, Gary J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review</atitle><jtitle>Gerontology (Basel)</jtitle><addtitle>Gerontology</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>61</volume><issue>5</issue><spage>427</spage><epage>434</epage><pages>427-434</pages><issn>0304-324X</issn><eissn>1423-0003</eissn><abstract>Human skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo progressive loss and fragmentation, leading to thin and structurally weakened skin. Age-related alterations of collagen fibrils impairs skin structure and function and creates a tissue microenvironment that promotes age-related skin diseases, such as delayed wound healing and skin cancer development. This mini-review describes cellular mechanisms that give rise to self-perpetuating, collagen fibril fragmentation that creates an age-associated dermal microenvironment, which contributes to decline of human skin function.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>25660807</pmid><doi>10.1159/000371708</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Gerontology (Basel), 2015-01, Vol.61 (5), p.427-434 |
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| source | Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Aging Aging - pathology Aging - physiology Cellular Microenvironment Collagen Connective Tissue - pathology Connective Tissue - physiopathology Cysteine-Rich Protein 61 - metabolism Dermatology Experimental Section / Mini-Review Extracellular matrix Extracellular Matrix - pathology Extracellular Matrix - physiology Gerontology Health aspects Humans Matrix Metalloproteinases - metabolism Models, Biological Physiological aspects Physiological research Proteins Signal Transduction Skin Skin aging Skin Aging - pathology Skin Aging - physiology Skin Diseases - etiology Transforming Growth Factor beta - metabolism |
| title | Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review |
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