IgE Sensitization to Thaumetopoea pityocampa: Diagnostic Utility of a Setae Extract, Clinical Picture and Associated Risk Factors
Background: Setae from Thaumetopoea pityocampa larvae (the pine processionary moth or PPM) can induce hypersensitivity reactions, but their clinical role in IgE-mediated responses is still subject to discussion. The aim of this study was to evaluate a setae extract for in vivo and in vitro diagnosis...
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| Veröffentlicht in: | International archives of allergy and immunology 2014-01, Vol.165 (4), p.283-290 |
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| creator | Vega, José María Moneo, Ignacio García-Ortiz, José Carlos González-Muñoz, Miguel Ruiz, Carmen Rodríguez-Mahillo, Ana Isabel Roques, Alain Vega, Jesús |
| description | Background: Setae from Thaumetopoea pityocampa larvae (the pine processionary moth or PPM) can induce hypersensitivity reactions, but their clinical role in IgE-mediated responses is still subject to discussion. The aim of this study was to evaluate a setae extract for in vivo and in vitro diagnosis in nonhospitalized patients with reactions to PPM. Methods: Forty-eight adult patients presenting with PPM cutaneous reactions were studied by skin prick test (SPT) and specific IgE using setae and whole larval (WL) extracts. Biological standardized extracts were used for skin tests. Results: A total of 47.9% patients had a positive SPT for PPM (70% to both extracts, 17% only to the WL extract and 13% only to the setae extract). IgE immunoblotting detected several reactive bands in 91% of the SPT-positive cases. In multivariate analysis, male sex, immediate latency ( |
| doi_str_mv | 10.1159/000369807 |
| format | Article |
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The aim of this study was to evaluate a setae extract for in vivo and in vitro diagnosis in nonhospitalized patients with reactions to PPM. Methods: Forty-eight adult patients presenting with PPM cutaneous reactions were studied by skin prick test (SPT) and specific IgE using setae and whole larval (WL) extracts. Biological standardized extracts were used for skin tests. Results: A total of 47.9% patients had a positive SPT for PPM (70% to both extracts, 17% only to the WL extract and 13% only to the setae extract). IgE immunoblotting detected several reactive bands in 91% of the SPT-positive cases. In multivariate analysis, male sex, immediate latency (<1 h) and duration of skin symptoms (<24 h) were independent predictors of a positive SPT. Conclusions: IgE sensitization to PPM was found in 48% of the study patients, which was associated with immediate reactions and evanescent cutaneous lesions. Most of these patients reacted to both WL and setae extracts, but some reacted to only one of them. According to our data, skin and in vitro tests to PPM should be performed using both extracts.</description><identifier>ISSN: 1018-2438</identifier><identifier>EISSN: 1423-0097</identifier><identifier>DOI: 10.1159/000369807</identifier><identifier>PMID: 25661274</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adolescent ; Adult ; Allergies ; Allergology ; Animal biology ; Animals ; Biodiversity and Ecology ; Cross-Sectional Studies ; Dermatitis, Allergic Contact - diagnosis ; Dermatitis, Allergic Contact - immunology ; Diagnosis ; Environmental Sciences ; Female ; Health aspects ; Humans ; Hypersensitivity, Immediate - diagnosis ; Hypersensitivity, Immediate - immunology ; Immunoblotting ; Immunoglobulin E ; Immunoglobulin E - blood ; Immunoglobulin E - immunology ; Immunoglobulins ; Immunology ; Insect allergy ; Insects ; Invertebrate Zoology ; Larva - immunology ; Life Sciences ; Logistic Models ; Male ; Moths ; Moths - immunology ; Original Paper ; Physiological aspects ; Risk factors ; Santé publique et épidémiologie ; Skin Tests - methods ; Spain ; Thaumetopoea pityocampa ; Young Adult</subject><ispartof>International archives of allergy and immunology, 2014-01, Vol.165 (4), p.283-290</ispartof><rights>2015 S. Karger AG, Basel</rights><rights>2015 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2015 S. Karger AG</rights><rights>Copyright (c) 2015 S. Karger AG, Basel</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-c8e05b8b49e0430db9a6ebdace62ba5c1f62e2ac2b1960631332405e02ae7d993</citedby><cites>FETCH-LOGICAL-c502t-c8e05b8b49e0430db9a6ebdace62ba5c1f62e2ac2b1960631332405e02ae7d993</cites><orcidid>0000-0002-3734-3918</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25661274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02631901$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Vega, José María</creatorcontrib><creatorcontrib>Moneo, Ignacio</creatorcontrib><creatorcontrib>García-Ortiz, José Carlos</creatorcontrib><creatorcontrib>González-Muñoz, Miguel</creatorcontrib><creatorcontrib>Ruiz, Carmen</creatorcontrib><creatorcontrib>Rodríguez-Mahillo, Ana Isabel</creatorcontrib><creatorcontrib>Roques, Alain</creatorcontrib><creatorcontrib>Vega, Jesús</creatorcontrib><title>IgE Sensitization to Thaumetopoea pityocampa: Diagnostic Utility of a Setae Extract, Clinical Picture and Associated Risk Factors</title><title>International archives of allergy and immunology</title><addtitle>Int Arch Allergy Immunol</addtitle><description>Background: Setae from Thaumetopoea pityocampa larvae (the pine processionary moth or PPM) can induce hypersensitivity reactions, but their clinical role in IgE-mediated responses is still subject to discussion. The aim of this study was to evaluate a setae extract for in vivo and in vitro diagnosis in nonhospitalized patients with reactions to PPM. Methods: Forty-eight adult patients presenting with PPM cutaneous reactions were studied by skin prick test (SPT) and specific IgE using setae and whole larval (WL) extracts. Biological standardized extracts were used for skin tests. Results: A total of 47.9% patients had a positive SPT for PPM (70% to both extracts, 17% only to the WL extract and 13% only to the setae extract). IgE immunoblotting detected several reactive bands in 91% of the SPT-positive cases. In multivariate analysis, male sex, immediate latency (<1 h) and duration of skin symptoms (<24 h) were independent predictors of a positive SPT. Conclusions: IgE sensitization to PPM was found in 48% of the study patients, which was associated with immediate reactions and evanescent cutaneous lesions. Most of these patients reacted to both WL and setae extracts, but some reacted to only one of them. According to our data, skin and in vitro tests to PPM should be performed using both extracts.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergies</subject><subject>Allergology</subject><subject>Animal biology</subject><subject>Animals</subject><subject>Biodiversity and Ecology</subject><subject>Cross-Sectional Studies</subject><subject>Dermatitis, Allergic Contact - diagnosis</subject><subject>Dermatitis, Allergic Contact - immunology</subject><subject>Diagnosis</subject><subject>Environmental Sciences</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - diagnosis</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>Immunoblotting</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunoglobulins</subject><subject>Immunology</subject><subject>Insect allergy</subject><subject>Insects</subject><subject>Invertebrate Zoology</subject><subject>Larva - immunology</subject><subject>Life Sciences</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Moths</subject><subject>Moths - immunology</subject><subject>Original Paper</subject><subject>Physiological aspects</subject><subject>Risk factors</subject><subject>Santé publique et épidémiologie</subject><subject>Skin Tests - methods</subject><subject>Spain</subject><subject>Thaumetopoea pityocampa</subject><subject>Young Adult</subject><issn>1018-2438</issn><issn>1423-0097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0kGL1DAUB_AiiruuHryLBARRsPqStGnjbRhn3YUBRXfP5TV9M5PdthmTVFxvfnMzzDiCJ08JyS__8Hgvy55yeMt5qd8BgFS6hupedsoLIXMAXd1Pe-B1LgpZn2SPQrgBSLhWD7MTUSrFRVWcZr8u1wv2lcZgo_2J0bqRRceuNjgNFN3WEbKtjXfO4LDF9-yDxfXoQrSGXUfbpxvmVgxTQkRiix_Ro4lv2Ly3ozXYs8_WxMkTw7FjsxCcsRipY19suGXniTofHmcPVtgHenJYz7Lr88XV_CJffvp4OZ8tc1OCiLmpCcq2bgtNUEjoWo2K2g4NKdFiafhKCRJoRMu1AiW5lKKAkkAgVZ3W8ix7vc_dYN9svR3Q3zUObXMxWza7MxDplQb-nSf7am-33n2bKMRmsMFQ3-NIbgoNV6rgWtRQ_wctJRdFWVWJvviH3rjJj6noXaDURanELvDlXq2xp2ZD2MdNcP20601oZkpWgqfmqb8FGe9C8LQ6VsWh2c1Fc5yLZJ8fvp7agbqj_DMICTzbg1v0a_JHcHj_G4REuTU</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Vega, José María</creator><creator>Moneo, Ignacio</creator><creator>García-Ortiz, José Carlos</creator><creator>González-Muñoz, Miguel</creator><creator>Ruiz, Carmen</creator><creator>Rodríguez-Mahillo, Ana Isabel</creator><creator>Roques, Alain</creator><creator>Vega, Jesús</creator><general>S. 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diagnosis</topic><topic>Dermatitis, Allergic Contact - immunology</topic><topic>Diagnosis</topic><topic>Environmental Sciences</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - diagnosis</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>Immunoblotting</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunoglobulins</topic><topic>Immunology</topic><topic>Insect allergy</topic><topic>Insects</topic><topic>Invertebrate Zoology</topic><topic>Larva - immunology</topic><topic>Life Sciences</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Moths</topic><topic>Moths - immunology</topic><topic>Original Paper</topic><topic>Physiological aspects</topic><topic>Risk factors</topic><topic>Santé publique et épidémiologie</topic><topic>Skin Tests - methods</topic><topic>Spain</topic><topic>Thaumetopoea pityocampa</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vega, José María</creatorcontrib><creatorcontrib>Moneo, Ignacio</creatorcontrib><creatorcontrib>García-Ortiz, José Carlos</creatorcontrib><creatorcontrib>González-Muñoz, Miguel</creatorcontrib><creatorcontrib>Ruiz, Carmen</creatorcontrib><creatorcontrib>Rodríguez-Mahillo, Ana Isabel</creatorcontrib><creatorcontrib>Roques, Alain</creatorcontrib><creatorcontrib>Vega, Jesús</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>International archives of allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vega, José María</au><au>Moneo, Ignacio</au><au>García-Ortiz, José Carlos</au><au>González-Muñoz, Miguel</au><au>Ruiz, Carmen</au><au>Rodríguez-Mahillo, Ana Isabel</au><au>Roques, Alain</au><au>Vega, Jesús</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgE Sensitization to Thaumetopoea pityocampa: Diagnostic Utility of a Setae Extract, Clinical Picture and Associated Risk Factors</atitle><jtitle>International archives of allergy and immunology</jtitle><addtitle>Int Arch Allergy Immunol</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>165</volume><issue>4</issue><spage>283</spage><epage>290</epage><pages>283-290</pages><issn>1018-2438</issn><eissn>1423-0097</eissn><abstract>Background: Setae from Thaumetopoea pityocampa larvae (the pine processionary moth or PPM) can induce hypersensitivity reactions, but their clinical role in IgE-mediated responses is still subject to discussion. The aim of this study was to evaluate a setae extract for in vivo and in vitro diagnosis in nonhospitalized patients with reactions to PPM. Methods: Forty-eight adult patients presenting with PPM cutaneous reactions were studied by skin prick test (SPT) and specific IgE using setae and whole larval (WL) extracts. Biological standardized extracts were used for skin tests. Results: A total of 47.9% patients had a positive SPT for PPM (70% to both extracts, 17% only to the WL extract and 13% only to the setae extract). IgE immunoblotting detected several reactive bands in 91% of the SPT-positive cases. In multivariate analysis, male sex, immediate latency (<1 h) and duration of skin symptoms (<24 h) were independent predictors of a positive SPT. Conclusions: IgE sensitization to PPM was found in 48% of the study patients, which was associated with immediate reactions and evanescent cutaneous lesions. Most of these patients reacted to both WL and setae extracts, but some reacted to only one of them. According to our data, skin and in vitro tests to PPM should be performed using both extracts.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>25661274</pmid><doi>10.1159/000369807</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3734-3918</orcidid></addata></record> |
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| ispartof | International archives of allergy and immunology, 2014-01, Vol.165 (4), p.283-290 |
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| language | eng |
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| subjects | Adolescent Adult Allergies Allergology Animal biology Animals Biodiversity and Ecology Cross-Sectional Studies Dermatitis, Allergic Contact - diagnosis Dermatitis, Allergic Contact - immunology Diagnosis Environmental Sciences Female Health aspects Humans Hypersensitivity, Immediate - diagnosis Hypersensitivity, Immediate - immunology Immunoblotting Immunoglobulin E Immunoglobulin E - blood Immunoglobulin E - immunology Immunoglobulins Immunology Insect allergy Insects Invertebrate Zoology Larva - immunology Life Sciences Logistic Models Male Moths Moths - immunology Original Paper Physiological aspects Risk factors Santé publique et épidémiologie Skin Tests - methods Spain Thaumetopoea pityocampa Young Adult |
| title | IgE Sensitization to Thaumetopoea pityocampa: Diagnostic Utility of a Setae Extract, Clinical Picture and Associated Risk Factors |
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