Underexpression of miR-126 and miR-20b in Hereditary and Nonhereditary Colorectal Tumors
Objectives: The aim of the study was to determine the significance of miR-126 and miR-20b in colorectal carcinogenesis. Methods: We analyzed the expressions of miR-126 and miR-20b in 136 colorectal tumors from 39 microsatellite stable (MSS) tumors, 23 high microsatellite instability (MSI-H) tumors,...
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| Veröffentlicht in: | Oncology 2014-01, Vol.87 (1), p.58-66 |
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| creator | Yamaguchi, Tatsuro Iijima, Takeru Wakaume, Rika Takahashi, Keiichi Matsumoto, Hiroshi Nakano, Daisuke Nakayama, Yujiro Mori, Takeo Horiguchi, Shinichiro Miyaki, Michiko |
| description | Objectives: The aim of the study was to determine the significance of miR-126 and miR-20b in colorectal carcinogenesis. Methods: We analyzed the expressions of miR-126 and miR-20b in 136 colorectal tumors from 39 microsatellite stable (MSS) tumors, 23 high microsatellite instability (MSI-H) tumors, 16 Lynch syndrome, and 58 familial adenomatous polyposis (FAP) tumors including adenoma, intramucosal carcinoma, and invasive carcinoma. Results: All four kinds of tumors showed underexpression of both miR-126 and miR-20b. The frequency of miR-126 downregulation was 100.0% in FAP adenomas, 85.7% in FAP intramucosal carcinomas, 78.9% in invasive carcinomas, 81.3% in Lynch syndrome tumors, 68.4% in MSS tumors, and 65.4% in MSI-H tumors. The frequency of miR-20b downregulation was 64.0% in FAP adenomas, 50.0% in FAP intramucosal carcinomas, 73.3% in invasive carcinomas, 62.5% in Lynch syndrome tumors, 79.5% in MSS tumors, and 91.3% in MSI-H tumors. The current study demonstrated underexpression of miR-126 and miR-20b in various types of colorectal cancer. These findings support the hypothesis that angiogenesis results from underexpressions of miR-126 and miR-20b and occurs as an early event in colorectal carcinogenesis. Conclusions: Underexpression of miR-126 and miR-20b was observed in various types of colorectal cancer, and occurs as an early event of colorectal carcinogenesis in FAP tumors. |
| doi_str_mv | 10.1159/000363303 |
| format | Article |
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Methods: We analyzed the expressions of miR-126 and miR-20b in 136 colorectal tumors from 39 microsatellite stable (MSS) tumors, 23 high microsatellite instability (MSI-H) tumors, 16 Lynch syndrome, and 58 familial adenomatous polyposis (FAP) tumors including adenoma, intramucosal carcinoma, and invasive carcinoma. Results: All four kinds of tumors showed underexpression of both miR-126 and miR-20b. The frequency of miR-126 downregulation was 100.0% in FAP adenomas, 85.7% in FAP intramucosal carcinomas, 78.9% in invasive carcinomas, 81.3% in Lynch syndrome tumors, 68.4% in MSS tumors, and 65.4% in MSI-H tumors. The frequency of miR-20b downregulation was 64.0% in FAP adenomas, 50.0% in FAP intramucosal carcinomas, 73.3% in invasive carcinomas, 62.5% in Lynch syndrome tumors, 79.5% in MSS tumors, and 91.3% in MSI-H tumors. The current study demonstrated underexpression of miR-126 and miR-20b in various types of colorectal cancer. These findings support the hypothesis that angiogenesis results from underexpressions of miR-126 and miR-20b and occurs as an early event in colorectal carcinogenesis. Conclusions: Underexpression of miR-126 and miR-20b was observed in various types of colorectal cancer, and occurs as an early event of colorectal carcinogenesis in FAP tumors.</description><identifier>ISSN: 0030-2414</identifier><identifier>EISSN: 1423-0232</identifier><identifier>DOI: 10.1159/000363303</identifier><identifier>PMID: 24994098</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adenoma - genetics ; Adenoma - metabolism ; Adenomatous Polyposis Coli - genetics ; Adenomatous Polyposis Coli - metabolism ; Carcinogenesis - genetics ; Carcinogenesis - metabolism ; Carcinoma - genetics ; Carcinoma - metabolism ; Clinical Translational Research ; Colorectal cancer ; Colorectal Neoplasms, Hereditary Nonpolyposis - genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism ; Gene Expression ; Humans ; MicroRNAs ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Microsatellite Instability</subject><ispartof>Oncology, 2014-01, Vol.87 (1), p.58-66</ispartof><rights>2014 S. Karger AG, Basel</rights><rights>2014 S. Karger AG, Basel.</rights><rights>Copyright (c) 2014 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-d1a557d77858d2348ba0144e82c4609ee56d6f2b6553c3f4e68e39c854d841383</citedby><cites>FETCH-LOGICAL-c461t-d1a557d77858d2348ba0144e82c4609ee56d6f2b6553c3f4e68e39c854d841383</cites><orcidid>0000-0001-8454-1995</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24994098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamaguchi, Tatsuro</creatorcontrib><creatorcontrib>Iijima, Takeru</creatorcontrib><creatorcontrib>Wakaume, Rika</creatorcontrib><creatorcontrib>Takahashi, Keiichi</creatorcontrib><creatorcontrib>Matsumoto, Hiroshi</creatorcontrib><creatorcontrib>Nakano, Daisuke</creatorcontrib><creatorcontrib>Nakayama, Yujiro</creatorcontrib><creatorcontrib>Mori, Takeo</creatorcontrib><creatorcontrib>Horiguchi, Shinichiro</creatorcontrib><creatorcontrib>Miyaki, Michiko</creatorcontrib><title>Underexpression of miR-126 and miR-20b in Hereditary and Nonhereditary Colorectal Tumors</title><title>Oncology</title><addtitle>Oncology</addtitle><description>Objectives: The aim of the study was to determine the significance of miR-126 and miR-20b in colorectal carcinogenesis. Methods: We analyzed the expressions of miR-126 and miR-20b in 136 colorectal tumors from 39 microsatellite stable (MSS) tumors, 23 high microsatellite instability (MSI-H) tumors, 16 Lynch syndrome, and 58 familial adenomatous polyposis (FAP) tumors including adenoma, intramucosal carcinoma, and invasive carcinoma. Results: All four kinds of tumors showed underexpression of both miR-126 and miR-20b. The frequency of miR-126 downregulation was 100.0% in FAP adenomas, 85.7% in FAP intramucosal carcinomas, 78.9% in invasive carcinomas, 81.3% in Lynch syndrome tumors, 68.4% in MSS tumors, and 65.4% in MSI-H tumors. The frequency of miR-20b downregulation was 64.0% in FAP adenomas, 50.0% in FAP intramucosal carcinomas, 73.3% in invasive carcinomas, 62.5% in Lynch syndrome tumors, 79.5% in MSS tumors, and 91.3% in MSI-H tumors. The current study demonstrated underexpression of miR-126 and miR-20b in various types of colorectal cancer. These findings support the hypothesis that angiogenesis results from underexpressions of miR-126 and miR-20b and occurs as an early event in colorectal carcinogenesis. Conclusions: Underexpression of miR-126 and miR-20b was observed in various types of colorectal cancer, and occurs as an early event of colorectal carcinogenesis in FAP tumors.</description><subject>Adenoma - genetics</subject><subject>Adenoma - metabolism</subject><subject>Adenomatous Polyposis Coli - genetics</subject><subject>Adenomatous Polyposis Coli - metabolism</subject><subject>Carcinogenesis - genetics</subject><subject>Carcinogenesis - metabolism</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - metabolism</subject><subject>Clinical Translational Research</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms, Hereditary Nonpolyposis - genetics</subject><subject>Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Microsatellite Instability</subject><issn>0030-2414</issn><issn>1423-0232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0c9LwzAUB_AgipvTg3eRghc9VPO76VGKOmE4kA28lbRJtbNtatKC_vdmP9xAPHhKeO_D95E8AE4RvEaIxTcQQsIJgWQPDBHFJISY4H0w9GUYYoroABw5t_AsYpQfggGmcUxhLIbgZd4obfVna7VzpWkCUwR1-RwizAPZqNUdwywom2DsnSo7ab9WnSfTvO0qiamM1Xknq2DW18a6Y3BQyMrpk805AvP7u1kyDifTh8fkdhLmlKMuVEgyFqkoEkwoTKjIJESUaoF9H8ZaM654gTPOGMlJQTUXmsS5YFQJioggI3C5zm2t-ei169K6dLmuKtlo07sUMc6FH8HQPyilEYliTD29-EUXpreNf8gykBDGcQS9ulqr3BrnrC7S1pa1_44UwXS5mXS7GW_PN4l9Vmu1lT-r2I18l_ZV2y2YJpN1RNqqwquzP9Vmyjf2oJmD</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Yamaguchi, Tatsuro</creator><creator>Iijima, Takeru</creator><creator>Wakaume, Rika</creator><creator>Takahashi, Keiichi</creator><creator>Matsumoto, Hiroshi</creator><creator>Nakano, Daisuke</creator><creator>Nakayama, Yujiro</creator><creator>Mori, Takeo</creator><creator>Horiguchi, Shinichiro</creator><creator>Miyaki, Michiko</creator><general>S. 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genetics</topic><topic>Adenoma - metabolism</topic><topic>Adenomatous Polyposis Coli - genetics</topic><topic>Adenomatous Polyposis Coli - metabolism</topic><topic>Carcinogenesis - genetics</topic><topic>Carcinogenesis - metabolism</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - metabolism</topic><topic>Clinical Translational Research</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms, Hereditary Nonpolyposis - genetics</topic><topic>Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Microsatellite Instability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamaguchi, Tatsuro</creatorcontrib><creatorcontrib>Iijima, Takeru</creatorcontrib><creatorcontrib>Wakaume, Rika</creatorcontrib><creatorcontrib>Takahashi, Keiichi</creatorcontrib><creatorcontrib>Matsumoto, Hiroshi</creatorcontrib><creatorcontrib>Nakano, Daisuke</creatorcontrib><creatorcontrib>Nakayama, Yujiro</creatorcontrib><creatorcontrib>Mori, Takeo</creatorcontrib><creatorcontrib>Horiguchi, Shinichiro</creatorcontrib><creatorcontrib>Miyaki, Michiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamaguchi, Tatsuro</au><au>Iijima, Takeru</au><au>Wakaume, Rika</au><au>Takahashi, Keiichi</au><au>Matsumoto, Hiroshi</au><au>Nakano, Daisuke</au><au>Nakayama, Yujiro</au><au>Mori, Takeo</au><au>Horiguchi, Shinichiro</au><au>Miyaki, Michiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Underexpression of miR-126 and miR-20b in Hereditary and Nonhereditary Colorectal Tumors</atitle><jtitle>Oncology</jtitle><addtitle>Oncology</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>87</volume><issue>1</issue><spage>58</spage><epage>66</epage><pages>58-66</pages><issn>0030-2414</issn><eissn>1423-0232</eissn><abstract>Objectives: The aim of the study was to determine the significance of miR-126 and miR-20b in colorectal carcinogenesis. Methods: We analyzed the expressions of miR-126 and miR-20b in 136 colorectal tumors from 39 microsatellite stable (MSS) tumors, 23 high microsatellite instability (MSI-H) tumors, 16 Lynch syndrome, and 58 familial adenomatous polyposis (FAP) tumors including adenoma, intramucosal carcinoma, and invasive carcinoma. Results: All four kinds of tumors showed underexpression of both miR-126 and miR-20b. The frequency of miR-126 downregulation was 100.0% in FAP adenomas, 85.7% in FAP intramucosal carcinomas, 78.9% in invasive carcinomas, 81.3% in Lynch syndrome tumors, 68.4% in MSS tumors, and 65.4% in MSI-H tumors. The frequency of miR-20b downregulation was 64.0% in FAP adenomas, 50.0% in FAP intramucosal carcinomas, 73.3% in invasive carcinomas, 62.5% in Lynch syndrome tumors, 79.5% in MSS tumors, and 91.3% in MSI-H tumors. The current study demonstrated underexpression of miR-126 and miR-20b in various types of colorectal cancer. These findings support the hypothesis that angiogenesis results from underexpressions of miR-126 and miR-20b and occurs as an early event in colorectal carcinogenesis. Conclusions: Underexpression of miR-126 and miR-20b was observed in various types of colorectal cancer, and occurs as an early event of colorectal carcinogenesis in FAP tumors.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>24994098</pmid><doi>10.1159/000363303</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8454-1995</orcidid></addata></record> |
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| source | Karger Journals; MEDLINE |
| subjects | Adenoma - genetics Adenoma - metabolism Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli - metabolism Carcinogenesis - genetics Carcinogenesis - metabolism Carcinoma - genetics Carcinoma - metabolism Clinical Translational Research Colorectal cancer Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism Gene Expression Humans MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Microsatellite Instability |
| title | Underexpression of miR-126 and miR-20b in Hereditary and Nonhereditary Colorectal Tumors |
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