Intracranial Metastasis in a Patient with Hepatocellular Carcinoma and Gastric Cancer
A 76-year-old man was referred to our hospital with visual disturbance, weakness of the left upper and lower limbs, and gait disturbance. He had previously received transarterial chemoembolization for hepatocellular carcinoma (HCC) 3 and 10 years ago. When he had received radiofrequency ablation for...
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| Veröffentlicht in: | Case reports in oncology 2014-03, Vol.7 (1), p.199-203 |
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| creator | Tawada, Akinobu Chiba, Tetsuhiro Ooka, Yoshihiko Yokota, Hajime Kanogawa, Naoya Motoyama, Tenyu Saito, Tomoko Ogasawara, Sadahisa Suzuki, Eiichiro Hanari, Naoyuki Matsubara, Hisahiro Saeki, Naokatsu Kambe, Michiyo Kishimoto, Takashi Nakatani, Yukio Yokosuka, Osamu |
| description | A 76-year-old man was referred to our hospital with visual disturbance, weakness of the left upper and lower limbs, and gait disturbance. He had previously received transarterial chemoembolization for hepatocellular carcinoma (HCC) 3 and 10 years ago. When he had received radiofrequency ablation for HCC recurrence 2 years ago, total gastrectomy was also performed for his gastric cancer. Subsequently, sorafenib had been administrated for concomitant lung metastatic tumors. On admission, MRI revealed an intra-axial tumor with perifocal edema. The level of carcinoembryonic antigen, but not alpha-fetoprotein, markedly increased. The tumor was successfully removed by craniotomy and pathological examination revealed that it was composed of adenocarcinoma, which was consistent with the primary gastric cancer. After surgery, his neurological disturbances rapidly resolved. Additional gamma-knife treatment was also performed for another small brain metastasis detected after craniotomy. Subsequently, sorafenib administration was discontinued and S-1 was administered postoperatively. Successful treatment of intracranial metastasis of gastric cancer is important and meaningful, even in patients with multiple primary malignancies. |
| doi_str_mv | 10.1159/000360982 |
| format | Article |
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He had previously received transarterial chemoembolization for hepatocellular carcinoma (HCC) 3 and 10 years ago. When he had received radiofrequency ablation for HCC recurrence 2 years ago, total gastrectomy was also performed for his gastric cancer. Subsequently, sorafenib had been administrated for concomitant lung metastatic tumors. On admission, MRI revealed an intra-axial tumor with perifocal edema. The level of carcinoembryonic antigen, but not alpha-fetoprotein, markedly increased. The tumor was successfully removed by craniotomy and pathological examination revealed that it was composed of adenocarcinoma, which was consistent with the primary gastric cancer. After surgery, his neurological disturbances rapidly resolved. Additional gamma-knife treatment was also performed for another small brain metastasis detected after craniotomy. Subsequently, sorafenib administration was discontinued and S-1 was administered postoperatively. Successful treatment of intracranial metastasis of gastric cancer is important and meaningful, even in patients with multiple primary malignancies.</description><identifier>ISSN: 1662-6575</identifier><identifier>EISSN: 1662-6575</identifier><identifier>DOI: 10.1159/000360982</identifier><identifier>PMID: 24748871</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Double cancer ; Gastric cancer ; Hepatocellular carcinoma ; Intracranial metastasis ; Multiple primary malignancy ; Published: March 2014 ; Surgical resection</subject><ispartof>Case reports in oncology, 2014-03, Vol.7 (1), p.199-203</ispartof><rights>2014 S. Karger AG, Basel</rights><rights>Copyright © 2014 by S. Karger AG, Basel 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-35b4397117d3202582c2cc1e9247aef000a5cfe77128444b6362d2f862f40d393</citedby><cites>FETCH-LOGICAL-c457t-35b4397117d3202582c2cc1e9247aef000a5cfe77128444b6362d2f862f40d393</cites><orcidid>0000-0002-6540-9064 ; 0000-0001-7179-0765</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985793/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985793/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,27639,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24748871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tawada, Akinobu</creatorcontrib><creatorcontrib>Chiba, Tetsuhiro</creatorcontrib><creatorcontrib>Ooka, Yoshihiko</creatorcontrib><creatorcontrib>Yokota, Hajime</creatorcontrib><creatorcontrib>Kanogawa, Naoya</creatorcontrib><creatorcontrib>Motoyama, Tenyu</creatorcontrib><creatorcontrib>Saito, Tomoko</creatorcontrib><creatorcontrib>Ogasawara, Sadahisa</creatorcontrib><creatorcontrib>Suzuki, Eiichiro</creatorcontrib><creatorcontrib>Hanari, Naoyuki</creatorcontrib><creatorcontrib>Matsubara, Hisahiro</creatorcontrib><creatorcontrib>Saeki, Naokatsu</creatorcontrib><creatorcontrib>Kambe, Michiyo</creatorcontrib><creatorcontrib>Kishimoto, Takashi</creatorcontrib><creatorcontrib>Nakatani, Yukio</creatorcontrib><creatorcontrib>Yokosuka, Osamu</creatorcontrib><title>Intracranial Metastasis in a Patient with Hepatocellular Carcinoma and Gastric Cancer</title><title>Case reports in oncology</title><addtitle>Case Rep Oncol</addtitle><description>A 76-year-old man was referred to our hospital with visual disturbance, weakness of the left upper and lower limbs, and gait disturbance. He had previously received transarterial chemoembolization for hepatocellular carcinoma (HCC) 3 and 10 years ago. When he had received radiofrequency ablation for HCC recurrence 2 years ago, total gastrectomy was also performed for his gastric cancer. Subsequently, sorafenib had been administrated for concomitant lung metastatic tumors. On admission, MRI revealed an intra-axial tumor with perifocal edema. The level of carcinoembryonic antigen, but not alpha-fetoprotein, markedly increased. The tumor was successfully removed by craniotomy and pathological examination revealed that it was composed of adenocarcinoma, which was consistent with the primary gastric cancer. After surgery, his neurological disturbances rapidly resolved. Additional gamma-knife treatment was also performed for another small brain metastasis detected after craniotomy. Subsequently, sorafenib administration was discontinued and S-1 was administered postoperatively. Successful treatment of intracranial metastasis of gastric cancer is important and meaningful, even in patients with multiple primary malignancies.</description><subject>Double cancer</subject><subject>Gastric cancer</subject><subject>Hepatocellular carcinoma</subject><subject>Intracranial metastasis</subject><subject>Multiple primary malignancy</subject><subject>Published: March 2014</subject><subject>Surgical resection</subject><issn>1662-6575</issn><issn>1662-6575</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>DOA</sourceid><recordid>eNptkUtLxDAUhYMovhfuRQKuXIzmnWYjyOBjQFFE1-FOmozRTjukHcV_b7RaFIRAwr3nfDfJQWiPkmNKpTkhhHBFTMFW0CZVio2U1HL113kDbbXtMyHKSCXX0QYTWhSFppvocVJ3CVyCOkKFb3wHbV6xxbHGgO-gi77u8FvsnvCVX0DXOF9VywoSHkNysW7mgKEu8WX2pehytXY-7aC1AFXrd7_3bfR4cf4wvhpd315OxmfXIyek7kZcTgU3mlJdckaYLJhjzlFv8v3Ah_wskC54rSkrhBBTxRUrWSgUC4KU3PBtNOm5ZQPPdpHiHNK7bSDar0KTZhZSF13lLSOFYKr0zump8E6DUkZzTo0MPCiqMuu0Zy2W07kvnf_8mOoP9G-njk921rxabgqpDc-Aox7gUtO2yYfBS4n9zMkOOWXtwe9hg_InmCzY7wUvkGY-DYLBf_hve3x_2yvsogz8A4k6ogY</recordid><startdate>20140314</startdate><enddate>20140314</enddate><creator>Tawada, Akinobu</creator><creator>Chiba, Tetsuhiro</creator><creator>Ooka, Yoshihiko</creator><creator>Yokota, Hajime</creator><creator>Kanogawa, Naoya</creator><creator>Motoyama, Tenyu</creator><creator>Saito, Tomoko</creator><creator>Ogasawara, Sadahisa</creator><creator>Suzuki, Eiichiro</creator><creator>Hanari, Naoyuki</creator><creator>Matsubara, Hisahiro</creator><creator>Saeki, Naokatsu</creator><creator>Kambe, Michiyo</creator><creator>Kishimoto, Takashi</creator><creator>Nakatani, Yukio</creator><creator>Yokosuka, Osamu</creator><general>S. Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6540-9064</orcidid><orcidid>https://orcid.org/0000-0001-7179-0765</orcidid></search><sort><creationdate>20140314</creationdate><title>Intracranial Metastasis in a Patient with Hepatocellular Carcinoma and Gastric Cancer</title><author>Tawada, Akinobu ; Chiba, Tetsuhiro ; Ooka, Yoshihiko ; Yokota, Hajime ; Kanogawa, Naoya ; Motoyama, Tenyu ; Saito, Tomoko ; Ogasawara, Sadahisa ; Suzuki, Eiichiro ; Hanari, Naoyuki ; Matsubara, Hisahiro ; Saeki, Naokatsu ; Kambe, Michiyo ; Kishimoto, Takashi ; Nakatani, Yukio ; Yokosuka, Osamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-35b4397117d3202582c2cc1e9247aef000a5cfe77128444b6362d2f862f40d393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Double cancer</topic><topic>Gastric cancer</topic><topic>Hepatocellular carcinoma</topic><topic>Intracranial metastasis</topic><topic>Multiple primary malignancy</topic><topic>Published: March 2014</topic><topic>Surgical resection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tawada, Akinobu</creatorcontrib><creatorcontrib>Chiba, Tetsuhiro</creatorcontrib><creatorcontrib>Ooka, Yoshihiko</creatorcontrib><creatorcontrib>Yokota, Hajime</creatorcontrib><creatorcontrib>Kanogawa, Naoya</creatorcontrib><creatorcontrib>Motoyama, Tenyu</creatorcontrib><creatorcontrib>Saito, Tomoko</creatorcontrib><creatorcontrib>Ogasawara, Sadahisa</creatorcontrib><creatorcontrib>Suzuki, Eiichiro</creatorcontrib><creatorcontrib>Hanari, Naoyuki</creatorcontrib><creatorcontrib>Matsubara, Hisahiro</creatorcontrib><creatorcontrib>Saeki, Naokatsu</creatorcontrib><creatorcontrib>Kambe, Michiyo</creatorcontrib><creatorcontrib>Kishimoto, Takashi</creatorcontrib><creatorcontrib>Nakatani, Yukio</creatorcontrib><creatorcontrib>Yokosuka, Osamu</creatorcontrib><collection>Karger Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Case reports in oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tawada, Akinobu</au><au>Chiba, Tetsuhiro</au><au>Ooka, Yoshihiko</au><au>Yokota, Hajime</au><au>Kanogawa, Naoya</au><au>Motoyama, Tenyu</au><au>Saito, Tomoko</au><au>Ogasawara, Sadahisa</au><au>Suzuki, Eiichiro</au><au>Hanari, Naoyuki</au><au>Matsubara, Hisahiro</au><au>Saeki, Naokatsu</au><au>Kambe, Michiyo</au><au>Kishimoto, Takashi</au><au>Nakatani, Yukio</au><au>Yokosuka, Osamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracranial Metastasis in a Patient with Hepatocellular Carcinoma and Gastric Cancer</atitle><jtitle>Case reports in oncology</jtitle><addtitle>Case Rep Oncol</addtitle><date>2014-03-14</date><risdate>2014</risdate><volume>7</volume><issue>1</issue><spage>199</spage><epage>203</epage><pages>199-203</pages><issn>1662-6575</issn><eissn>1662-6575</eissn><abstract>A 76-year-old man was referred to our hospital with visual disturbance, weakness of the left upper and lower limbs, and gait disturbance. He had previously received transarterial chemoembolization for hepatocellular carcinoma (HCC) 3 and 10 years ago. When he had received radiofrequency ablation for HCC recurrence 2 years ago, total gastrectomy was also performed for his gastric cancer. Subsequently, sorafenib had been administrated for concomitant lung metastatic tumors. On admission, MRI revealed an intra-axial tumor with perifocal edema. The level of carcinoembryonic antigen, but not alpha-fetoprotein, markedly increased. The tumor was successfully removed by craniotomy and pathological examination revealed that it was composed of adenocarcinoma, which was consistent with the primary gastric cancer. After surgery, his neurological disturbances rapidly resolved. Additional gamma-knife treatment was also performed for another small brain metastasis detected after craniotomy. Subsequently, sorafenib administration was discontinued and S-1 was administered postoperatively. 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| subjects | Double cancer Gastric cancer Hepatocellular carcinoma Intracranial metastasis Multiple primary malignancy Published: March 2014 Surgical resection |
| title | Intracranial Metastasis in a Patient with Hepatocellular Carcinoma and Gastric Cancer |
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