Intestinal Fatty Acid-Binding Protein in Neonates with Imminent Necrotizing Enterocolitis
Background: Intestinal fatty acid-binding protein (I-FABP) is a promising marker for necrotizing enterocolitis (NEC). It can be measured in plasma (I-FABPp) and urine (I-FABPu). Data on the best way to measure I-FABP (in plasma or urine) and the necessity of simultaneous measurement of the urinary c...
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| Veröffentlicht in: | Neonatology (Basel, Switzerland) Switzerland), 2014-01, Vol.106 (1), p.49-54 |
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| creator | Schurink, Maarten Scholten, Iemcke G.H. Kooi, Elisabeth M.W. Hulzebos, Christian V. Kox, Rozemarijn G. Groen, Henk Heineman, Erik Bos, Arend F. Hulscher, Jan B.F. |
| description | Background: Intestinal fatty acid-binding protein (I-FABP) is a promising marker for necrotizing enterocolitis (NEC). It can be measured in plasma (I-FABPp) and urine (I-FABPu). Data on the best way to measure I-FABP (in plasma or urine) and the necessity of simultaneous measurement of the urinary creatinine concentration to correct for physiological variations in urine concentration are not available. This holds also true for the reciprocal relation between I-FABPp, I-FABPu and other more conventional laboratory parameters. Objectives: To evaluate the above-mentioned correlations of I-FABP measurements in neonates with suspected NEC. Methods: All neonates with suspected NEC were prospectively included. I-FABPp and I-FABPu were analyzed at regular intervals during the first 24 h after onset of symptoms. Correlation and agreement were assessed between these and other parameters (i.e. IL-6, WBC, platelet count, CRP, pH and lactate). Results: Included were 24 boys, 13 girls [median (range) GA 28 weeks (24-36), median birth weight 1,190 g (570-2,400)]. I-FABPu correlated strongly with I-FABPp (r 0.80, p < 0.001) with an adequate agreement. A very strong correlation between I-FABPu and I-FABPu/urine creatinine ratio (r 0.98, p < 0.001) existed. Correlations between I-FABPp/u and conventional parameters were moderate to strong until 8 h after onset of symptoms. Conclusion: In neonates with suspected NEC, I-FABPu correlates strongly with I-FABPp, offering an opportunity to choose the most appropriate way of measuring I-FABP. Calculating urinary IFABP/creatinine ratio seems redundant. Moderately strong correlations between I-FABPu and IL-6, WBC and lactate were found. |
| doi_str_mv | 10.1159/000358582 |
| format | Article |
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It can be measured in plasma (I-FABPp) and urine (I-FABPu). Data on the best way to measure I-FABP (in plasma or urine) and the necessity of simultaneous measurement of the urinary creatinine concentration to correct for physiological variations in urine concentration are not available. This holds also true for the reciprocal relation between I-FABPp, I-FABPu and other more conventional laboratory parameters. Objectives: To evaluate the above-mentioned correlations of I-FABP measurements in neonates with suspected NEC. Methods: All neonates with suspected NEC were prospectively included. I-FABPp and I-FABPu were analyzed at regular intervals during the first 24 h after onset of symptoms. Correlation and agreement were assessed between these and other parameters (i.e. IL-6, WBC, platelet count, CRP, pH and lactate). Results: Included were 24 boys, 13 girls [median (range) GA 28 weeks (24-36), median birth weight 1,190 g (570-2,400)]. I-FABPu correlated strongly with I-FABPp (r 0.80, p < 0.001) with an adequate agreement. A very strong correlation between I-FABPu and I-FABPu/urine creatinine ratio (r 0.98, p < 0.001) existed. Correlations between I-FABPp/u and conventional parameters were moderate to strong until 8 h after onset of symptoms. Conclusion: In neonates with suspected NEC, I-FABPu correlates strongly with I-FABPp, offering an opportunity to choose the most appropriate way of measuring I-FABP. Calculating urinary IFABP/creatinine ratio seems redundant. Moderately strong correlations between I-FABPu and IL-6, WBC and lactate were found.</description><identifier>ISSN: 1661-7800</identifier><identifier>EISSN: 1661-7819</identifier><identifier>DOI: 10.1159/000358582</identifier><identifier>PMID: 24818641</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Biomarkers - blood ; Biomarkers - urine ; C-Reactive Protein - metabolism ; Creatinine - urine ; Enterocolitis, Necrotizing - blood ; Enterocolitis, Necrotizing - diagnosis ; Enterocolitis, Necrotizing - pathology ; Enterocolitis, Necrotizing - urine ; Fatty Acid-Binding Proteins - blood ; Fatty Acid-Binding Proteins - urine ; Female ; Humans ; Hydrogen-Ion Concentration ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - blood ; Infant, Premature, Diseases - diagnosis ; Infant, Premature, Diseases - pathology ; Infant, Premature, Diseases - urine ; Interleukin-6 - blood ; Lactic Acid - blood ; Leukocyte Count ; Male ; Original Paper ; Platelet Count ; Prospective Studies ; Statistics, Nonparametric</subject><ispartof>Neonatology (Basel, Switzerland), 2014-01, Vol.106 (1), p.49-54</ispartof><rights>2014 S. Karger AG, Basel</rights><rights>Copyright S. Karger AG Jun 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-965785e74b692cd0102688c315a7318844debf6f23bc1fac20a7134f842cb1c53</citedby><cites>FETCH-LOGICAL-c369t-965785e74b692cd0102688c315a7318844debf6f23bc1fac20a7134f842cb1c53</cites><orcidid>0000-0002-8159-7501</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24818641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schurink, Maarten</creatorcontrib><creatorcontrib>Scholten, Iemcke G.H.</creatorcontrib><creatorcontrib>Kooi, Elisabeth M.W.</creatorcontrib><creatorcontrib>Hulzebos, Christian V.</creatorcontrib><creatorcontrib>Kox, Rozemarijn G.</creatorcontrib><creatorcontrib>Groen, Henk</creatorcontrib><creatorcontrib>Heineman, Erik</creatorcontrib><creatorcontrib>Bos, Arend F.</creatorcontrib><creatorcontrib>Hulscher, Jan B.F.</creatorcontrib><title>Intestinal Fatty Acid-Binding Protein in Neonates with Imminent Necrotizing Enterocolitis</title><title>Neonatology (Basel, Switzerland)</title><addtitle>Neonatology</addtitle><description>Background: Intestinal fatty acid-binding protein (I-FABP) is a promising marker for necrotizing enterocolitis (NEC). It can be measured in plasma (I-FABPp) and urine (I-FABPu). Data on the best way to measure I-FABP (in plasma or urine) and the necessity of simultaneous measurement of the urinary creatinine concentration to correct for physiological variations in urine concentration are not available. This holds also true for the reciprocal relation between I-FABPp, I-FABPu and other more conventional laboratory parameters. Objectives: To evaluate the above-mentioned correlations of I-FABP measurements in neonates with suspected NEC. Methods: All neonates with suspected NEC were prospectively included. I-FABPp and I-FABPu were analyzed at regular intervals during the first 24 h after onset of symptoms. Correlation and agreement were assessed between these and other parameters (i.e. IL-6, WBC, platelet count, CRP, pH and lactate). Results: Included were 24 boys, 13 girls [median (range) GA 28 weeks (24-36), median birth weight 1,190 g (570-2,400)]. I-FABPu correlated strongly with I-FABPp (r 0.80, p < 0.001) with an adequate agreement. A very strong correlation between I-FABPu and I-FABPu/urine creatinine ratio (r 0.98, p < 0.001) existed. Correlations between I-FABPp/u and conventional parameters were moderate to strong until 8 h after onset of symptoms. Conclusion: In neonates with suspected NEC, I-FABPu correlates strongly with I-FABPp, offering an opportunity to choose the most appropriate way of measuring I-FABP. Calculating urinary IFABP/creatinine ratio seems redundant. Moderately strong correlations between I-FABPu and IL-6, WBC and lactate were found.</description><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>C-Reactive Protein - metabolism</subject><subject>Creatinine - urine</subject><subject>Enterocolitis, Necrotizing - blood</subject><subject>Enterocolitis, Necrotizing - diagnosis</subject><subject>Enterocolitis, Necrotizing - pathology</subject><subject>Enterocolitis, Necrotizing - urine</subject><subject>Fatty Acid-Binding Proteins - blood</subject><subject>Fatty Acid-Binding Proteins - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - blood</subject><subject>Infant, Premature, Diseases - diagnosis</subject><subject>Infant, Premature, Diseases - pathology</subject><subject>Infant, Premature, Diseases - urine</subject><subject>Interleukin-6 - blood</subject><subject>Lactic Acid - blood</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Original Paper</subject><subject>Platelet Count</subject><subject>Prospective Studies</subject><subject>Statistics, Nonparametric</subject><issn>1661-7800</issn><issn>1661-7819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0L1LxDAYBvAgit-Du0jBRYdq3uaj6XjKnR4c6qCDU0nTVKNtqkmK6F9vjjs7CIGE8MsbngehI8AXAKy4xBgTJpjINtAucA5pLqDYHM8Y76A9798wZozxbBvtZFSA4BR20fPcBu2DsbJNZjKE72SiTJ1eGVsb-5I8uD5oY5O47nRvZbTJlwmvybzrjNU2xGsVjflZ6mmc5XrVtyYYf4C2Gtl6fbje99HTbPp4fZsu7m_m15NFqggvQlpwlgumc1rxIlM1BpxxIRQBJnMCQlBa66rhTUYqBY1UGZY5ENoImqkKFCP76Gw198P1n0PMUnbGK9220up-8CUwCiSnMW6kp__oWz-4GD2qnND4F-Y4qvOVisG8d7opP5zppPsuAZfLvsux72hP1hOHqtP1KP8KjuB4Bd6le9FuBOv3v80ZgjE</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Schurink, Maarten</creator><creator>Scholten, Iemcke G.H.</creator><creator>Kooi, Elisabeth M.W.</creator><creator>Hulzebos, Christian V.</creator><creator>Kox, Rozemarijn G.</creator><creator>Groen, Henk</creator><creator>Heineman, Erik</creator><creator>Bos, Arend F.</creator><creator>Hulscher, Jan B.F.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8159-7501</orcidid></search><sort><creationdate>20140101</creationdate><title>Intestinal Fatty Acid-Binding Protein in Neonates with Imminent Necrotizing Enterocolitis</title><author>Schurink, Maarten ; Scholten, Iemcke G.H. ; Kooi, Elisabeth M.W. ; Hulzebos, Christian V. ; Kox, Rozemarijn G. ; Groen, Henk ; Heineman, Erik ; Bos, Arend F. ; Hulscher, Jan B.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-965785e74b692cd0102688c315a7318844debf6f23bc1fac20a7134f842cb1c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>C-Reactive Protein - metabolism</topic><topic>Creatinine - urine</topic><topic>Enterocolitis, Necrotizing - blood</topic><topic>Enterocolitis, Necrotizing - diagnosis</topic><topic>Enterocolitis, Necrotizing - pathology</topic><topic>Enterocolitis, Necrotizing - urine</topic><topic>Fatty Acid-Binding Proteins - blood</topic><topic>Fatty Acid-Binding Proteins - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - blood</topic><topic>Infant, Premature, Diseases - diagnosis</topic><topic>Infant, Premature, Diseases - pathology</topic><topic>Infant, Premature, Diseases - urine</topic><topic>Interleukin-6 - blood</topic><topic>Lactic Acid - blood</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Original Paper</topic><topic>Platelet Count</topic><topic>Prospective Studies</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schurink, Maarten</creatorcontrib><creatorcontrib>Scholten, Iemcke G.H.</creatorcontrib><creatorcontrib>Kooi, Elisabeth M.W.</creatorcontrib><creatorcontrib>Hulzebos, Christian V.</creatorcontrib><creatorcontrib>Kox, Rozemarijn G.</creatorcontrib><creatorcontrib>Groen, Henk</creatorcontrib><creatorcontrib>Heineman, Erik</creatorcontrib><creatorcontrib>Bos, Arend F.</creatorcontrib><creatorcontrib>Hulscher, Jan B.F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neonatology (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schurink, Maarten</au><au>Scholten, Iemcke G.H.</au><au>Kooi, Elisabeth M.W.</au><au>Hulzebos, Christian V.</au><au>Kox, Rozemarijn G.</au><au>Groen, Henk</au><au>Heineman, Erik</au><au>Bos, Arend F.</au><au>Hulscher, Jan B.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal Fatty Acid-Binding Protein in Neonates with Imminent Necrotizing Enterocolitis</atitle><jtitle>Neonatology (Basel, Switzerland)</jtitle><addtitle>Neonatology</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>106</volume><issue>1</issue><spage>49</spage><epage>54</epage><pages>49-54</pages><issn>1661-7800</issn><eissn>1661-7819</eissn><abstract>Background: Intestinal fatty acid-binding protein (I-FABP) is a promising marker for necrotizing enterocolitis (NEC). It can be measured in plasma (I-FABPp) and urine (I-FABPu). Data on the best way to measure I-FABP (in plasma or urine) and the necessity of simultaneous measurement of the urinary creatinine concentration to correct for physiological variations in urine concentration are not available. This holds also true for the reciprocal relation between I-FABPp, I-FABPu and other more conventional laboratory parameters. Objectives: To evaluate the above-mentioned correlations of I-FABP measurements in neonates with suspected NEC. Methods: All neonates with suspected NEC were prospectively included. I-FABPp and I-FABPu were analyzed at regular intervals during the first 24 h after onset of symptoms. Correlation and agreement were assessed between these and other parameters (i.e. IL-6, WBC, platelet count, CRP, pH and lactate). Results: Included were 24 boys, 13 girls [median (range) GA 28 weeks (24-36), median birth weight 1,190 g (570-2,400)]. I-FABPu correlated strongly with I-FABPp (r 0.80, p < 0.001) with an adequate agreement. A very strong correlation between I-FABPu and I-FABPu/urine creatinine ratio (r 0.98, p < 0.001) existed. Correlations between I-FABPp/u and conventional parameters were moderate to strong until 8 h after onset of symptoms. Conclusion: In neonates with suspected NEC, I-FABPu correlates strongly with I-FABPp, offering an opportunity to choose the most appropriate way of measuring I-FABP. Calculating urinary IFABP/creatinine ratio seems redundant. Moderately strong correlations between I-FABPu and IL-6, WBC and lactate were found.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>24818641</pmid><doi>10.1159/000358582</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8159-7501</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers - blood Biomarkers - urine C-Reactive Protein - metabolism Creatinine - urine Enterocolitis, Necrotizing - blood Enterocolitis, Necrotizing - diagnosis Enterocolitis, Necrotizing - pathology Enterocolitis, Necrotizing - urine Fatty Acid-Binding Proteins - blood Fatty Acid-Binding Proteins - urine Female Humans Hydrogen-Ion Concentration Infant, Newborn Infant, Premature Infant, Premature, Diseases - blood Infant, Premature, Diseases - diagnosis Infant, Premature, Diseases - pathology Infant, Premature, Diseases - urine Interleukin-6 - blood Lactic Acid - blood Leukocyte Count Male Original Paper Platelet Count Prospective Studies Statistics, Nonparametric |
| title | Intestinal Fatty Acid-Binding Protein in Neonates with Imminent Necrotizing Enterocolitis |
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