Cardiovascular and Renal Effects of High Salt Diet in GDNF+/- Mice with Low Nephron Number

Aims: To test the suggested association of low nephron number and later development of renal and cardiovascular disease we investigated the effects of high sodium diet in heterozygous GDNF+/- mice. Methods: Aged wild type and GDNF+/- mice were grouped together according to high sodium (HS, 4%) or lo...

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Veröffentlicht in:	Kidney & blood pressure research 2013, Vol.37 (4-5), p.379-391
Hauptverfasser:	Schlote, Julia, Schröder, Agnes, Dahlmann, Anke, Karpe, Britta, Cordasic, Nada, Daniel, Christoph, Hilgers, Karl Friedrich, Titze, Jens, Amann, Kerstin, Benz, Kerstin
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria Animals Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cell Count Female Glial Cell Line-Derived Neurotrophic Factor - genetics Glial Cell Line-Derived Neurotrophic Factor - physiology Glomerulosclerosis Heart High salt Kidney Diseases - genetics Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Male Mice Mice, Inbred C57BL Mice, Transgenic Nephron number Nephrons - metabolism Nephrons - pathology Nephrons - ultrastructure Original Paper Random Allocation Renal vasculature Sodium Chloride, Dietary - adverse effects Tubular transporter Urinary production
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