Sex-Specific Gonadal and Gene Expression Changes throughout Development in Fathead Minnow
Although fathead minnows (Pimephales promelas) are commonly used as a model fish in endocrine disruption studies, past studies have not characterized sex-specific baseline expression of genes involved in sex differentiation during development in this species. Using a sex-linked DNA marker to verify...
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| Veröffentlicht in: | Sexual development 2013-01, Vol.7 (6), p.303-307 |
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| container_end_page | 307 |
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| container_issue | 6 |
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| container_title | Sexual development |
| container_volume | 7 |
| creator | Leet, J.K. Lesteberg, K.E. Schoenfuss, H.L. Olmstead, A.W. Amberg, J.J. Ankley, G.T. Sepúlveda, M.S. |
| description | Although fathead minnows (Pimephales promelas) are commonly used as a model fish in endocrine disruption studies, past studies have not characterized sex-specific baseline expression of genes involved in sex differentiation during development in this species. Using a sex-linked DNA marker to verify gender, we evaluated the expression over time of genes involved in sex differentiation (dmrt1, cyp19a, cyp17, star, esr1, ar) in developing fathead minnows (10-45 days post hatch). Evaluation of these molecular markers in combination with gender identification help us to better understand the mechanisms regulating sex differentiation in fathead minnows and how endocrine-disrupting chemicals may alter these processes. |
| doi_str_mv | 10.1159/000353877 |
| format | Article |
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Using a sex-linked DNA marker to verify gender, we evaluated the expression over time of genes involved in sex differentiation (dmrt1, cyp19a, cyp17, star, esr1, ar) in developing fathead minnows (10-45 days post hatch). Evaluation of these molecular markers in combination with gender identification help us to better understand the mechanisms regulating sex differentiation in fathead minnows and how endocrine-disrupting chemicals may alter these processes.</description><identifier>ISSN: 1661-5425</identifier><identifier>EISSN: 1661-5433</identifier><identifier>DOI: 10.1159/000353877</identifier><identifier>PMID: 23948860</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Animals ; Cyprinidae - genetics ; Cyprinidae - growth & development ; Endocrine Disruptors - pharmacology ; Female ; Gene Expression ; Gonads - growth & development ; Male ; Ovary - growth & development ; Sex Characteristics ; Sex Determination Analysis - veterinary ; Sex Differentiation - drug effects ; Sex Differentiation - genetics ; Sex Differentiation - physiology ; Short Report ; Testis - growth & development ; Time Factors</subject><ispartof>Sexual development, 2013-01, Vol.7 (6), p.303-307</ispartof><rights>2013 S. 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Evaluation of these molecular markers in combination with gender identification help us to better understand the mechanisms regulating sex differentiation in fathead minnows and how endocrine-disrupting chemicals may alter these processes.</description><subject>Animals</subject><subject>Cyprinidae - genetics</subject><subject>Cyprinidae - growth & development</subject><subject>Endocrine Disruptors - pharmacology</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gonads - growth & development</subject><subject>Male</subject><subject>Ovary - growth & development</subject><subject>Sex Characteristics</subject><subject>Sex Determination Analysis - veterinary</subject><subject>Sex Differentiation - drug effects</subject><subject>Sex Differentiation - genetics</subject><subject>Sex Differentiation - physiology</subject><subject>Short Report</subject><subject>Testis - growth & development</subject><subject>Time Factors</subject><issn>1661-5425</issn><issn>1661-5433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90DFPwzAQBWALgWgpDOwIeYQhYMeOnYyotAWpiKEwMEV2cmkCiR3sBMq_p6gl093wvTc8hM4puaE0Sm4JISxisZQHaEyFoEHEGTsc_jAaoRPv3wkRJAyjYzQKWcLjWJAxelvBJli1kFVFleGFNSpXNVYmxwswgGeb1oH3lTV4WiqzBo-70tl-Xdq-w_fwBbVtGzAdrgyeq64EleOnyhj7fYqOClV7ONvfCXqdz16mD8HyefE4vVsGGSOiCxiAkkzllOuCxknBQqUpYQVjOecqyeIi41JyyajONRE6kTHRIpSCCkq1UmyCrna9rbOfPfgubSqfQV0rA7b3KeUJkTxiCdvS6x3NnPXeQZG2rmqU-0kpSf-WTIclt_ZyX9vrBvJB_k-3BRc78KHcGtwA9vlf8Dh2bQ</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Leet, J.K.</creator><creator>Lesteberg, K.E.</creator><creator>Schoenfuss, H.L.</creator><creator>Olmstead, A.W.</creator><creator>Amberg, J.J.</creator><creator>Ankley, G.T.</creator><creator>Sepúlveda, M.S.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Sex-Specific Gonadal and Gene Expression Changes throughout Development in Fathead Minnow</title><author>Leet, J.K. ; Lesteberg, K.E. ; Schoenfuss, H.L. ; Olmstead, A.W. ; Amberg, J.J. ; Ankley, G.T. ; Sepúlveda, M.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c306t-3eea73ad14bf189f32ab103f33d44a9c8fc4774731bdb06b9780b62761611baa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Cyprinidae - genetics</topic><topic>Cyprinidae - growth & development</topic><topic>Endocrine Disruptors - pharmacology</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Gonads - growth & development</topic><topic>Male</topic><topic>Ovary - growth & development</topic><topic>Sex Characteristics</topic><topic>Sex Determination Analysis - veterinary</topic><topic>Sex Differentiation - drug effects</topic><topic>Sex Differentiation - genetics</topic><topic>Sex Differentiation - physiology</topic><topic>Short Report</topic><topic>Testis - growth & development</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leet, J.K.</creatorcontrib><creatorcontrib>Lesteberg, K.E.</creatorcontrib><creatorcontrib>Schoenfuss, H.L.</creatorcontrib><creatorcontrib>Olmstead, A.W.</creatorcontrib><creatorcontrib>Amberg, J.J.</creatorcontrib><creatorcontrib>Ankley, G.T.</creatorcontrib><creatorcontrib>Sepúlveda, M.S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Sexual development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leet, J.K.</au><au>Lesteberg, K.E.</au><au>Schoenfuss, H.L.</au><au>Olmstead, A.W.</au><au>Amberg, J.J.</au><au>Ankley, G.T.</au><au>Sepúlveda, M.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex-Specific Gonadal and Gene Expression Changes throughout Development in Fathead Minnow</atitle><jtitle>Sexual development</jtitle><addtitle>Sex Dev</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>7</volume><issue>6</issue><spage>303</spage><epage>307</epage><pages>303-307</pages><issn>1661-5425</issn><eissn>1661-5433</eissn><abstract>Although fathead minnows (Pimephales promelas) are commonly used as a model fish in endocrine disruption studies, past studies have not characterized sex-specific baseline expression of genes involved in sex differentiation during development in this species. 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| ispartof | Sexual development, 2013-01, Vol.7 (6), p.303-307 |
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| language | eng |
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| source | Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Cyprinidae - genetics Cyprinidae - growth & development Endocrine Disruptors - pharmacology Female Gene Expression Gonads - growth & development Male Ovary - growth & development Sex Characteristics Sex Determination Analysis - veterinary Sex Differentiation - drug effects Sex Differentiation - genetics Sex Differentiation - physiology Short Report Testis - growth & development Time Factors |
| title | Sex-Specific Gonadal and Gene Expression Changes throughout Development in Fathead Minnow |
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