Eosinophils: Multifunctional and Distinctive Properties
The eosinophil is a granulocyte prominent in allergic diseases and inflammatory responses against helminthic parasites. The eosinophil was named by Paul Ehrlich in 1879, and derives from the intense staining of its granules with the acidic dye eosin. It has been the subject of extensive investigatio...
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| Veröffentlicht in: | International archives of allergy and immunology 2013-01, Vol.161 (Suppl 2), p.3-9 |
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| container_title | International archives of allergy and immunology |
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| creator | Kita, Hirohito |
| description | The eosinophil is a granulocyte prominent in allergic diseases and inflammatory responses against helminthic parasites. The eosinophil was named by Paul Ehrlich in 1879, and derives from the intense staining of its granules with the acidic dye eosin. It has been the subject of extensive investigation ever since. It is strongly associated with human diseases involving mucosal surfaces, such as allergic asthma, atopic dermatitis and gastrointestinal disorders. Eosinophils are likely involved in tissue homeostasis, modulation of adaptive immune responses, innate immunity to certain microbes and pathological changes in allergic disorders. Thus, the eosinophil is considered a multifunctional leukocyte that contributes to a wide variety of physiological and pathological processes, depending on its location and activation status. Further studies will be necessary to better understand the biology of this extraordinary leukocyte and to reveal the importance of the cell in human health and disease. |
| doi_str_mv | 10.1159/000350662 |
| format | Article |
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The eosinophil was named by Paul Ehrlich in 1879, and derives from the intense staining of its granules with the acidic dye eosin. It has been the subject of extensive investigation ever since. It is strongly associated with human diseases involving mucosal surfaces, such as allergic asthma, atopic dermatitis and gastrointestinal disorders. Eosinophils are likely involved in tissue homeostasis, modulation of adaptive immune responses, innate immunity to certain microbes and pathological changes in allergic disorders. Thus, the eosinophil is considered a multifunctional leukocyte that contributes to a wide variety of physiological and pathological processes, depending on its location and activation status. 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Karger AG</publisher><subject>Allergies ; Animals ; Cytokines - immunology ; Cytokines - metabolism ; Eosinophils - immunology ; Eosinophils - metabolism ; Humans ; Inflammation Mediators - immunology ; Inflammation Mediators - metabolism ; Leukocytes ; Parasites ; Pathology ; Physiology ; Plenary Review</subject><ispartof>International archives of allergy and immunology, 2013-01, Vol.161 (Suppl 2), p.3-9</ispartof><rights>2013 S. Karger AG, Basel</rights><rights>Copyright © 2013 S. Karger AG, Basel.</rights><rights>Copyright (c) 2013 S. 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| source | MEDLINE; Karger Journals Complete; Alma/SFX Local Collection |
| subjects | Allergies Animals Cytokines - immunology Cytokines - metabolism Eosinophils - immunology Eosinophils - metabolism Humans Inflammation Mediators - immunology Inflammation Mediators - metabolism Leukocytes Parasites Pathology Physiology Plenary Review |
| title | Eosinophils: Multifunctional and Distinctive Properties |
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