Rapid Improvement of Hepatic Steatosis after Initiation of Leptin Substitution in a Leptin-Deficient Girl

Background: Leptin deficiency is associated with severe obesity and metabolic disturbances. Increased liver fat content has been reported in only one case beforehand, even though hepatic steatosis is a typical comorbidity of common obesity. It is also frequent in patients with lipodystrophy where it...

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Veröffentlicht in:	Hormone research in paediatrics 2013-01, Vol.79 (5), p.310-317
Hauptverfasser:	von Schnurbein, J., Heni, M., Moss, A., Nagel, S.A., Machann, J., Muehleder, H., Debatin, K.M., Farooqi, S., Wabitsch, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Cholesterol - blood Fatty Liver - blood Fatty Liver - drug therapy Fatty Liver - pathology Fatty Liver - physiopathology Female Homozygote Hormone Replacement Therapy Humans Leptin - deficiency Leptin - genetics Leptin - therapeutic use Lipoproteins, LDL - blood Liver - metabolism Liver - pathology Liver - physiopathology Mutation Novel Insights from Clinical Practice Time Factors
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