In vitro Modeling of Ryanodine Receptor 2 Dysfunction Using Human Induced Pluripotent Stem Cells

Background/Aims: Induced pluripotent stem (iPS) cells generated from accessible adult cells of patients with genetic diseases open unprecedented opportunities for exploring the pathophysiology of human diseases in vitro. Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is an inhe...

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Veröffentlicht in:	Cellular physiology and biochemistry 2011-01, Vol.28 (4), p.579-592
Hauptverfasser:	Fatima, Azra, Xu, Guoxing, Shao, Kaifeng, Papadopoulos, Symeon, Lehmann, Martin, Arnáiz-Cot, Juan J., Rosa, Angelo O., Nguemo, Filomain, Matzkies, Matthias, Dittmann, Sven, Stone, Susannah L., Linke, Matthias, Zechner, Ulrich, Beyer, Vera, Hennies, Hans Christian, Rosenkranz, Stephan, Klauke, Baerbel, Parwani, Abdul S., Haverkamp, Wilhelm, Pfitzer, Gabriele, Farr, Martin, Cleemann, Lars, Morad, Martin, Milting, Hendrik, Hescheler, Juergen, Šaric, Tomo
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Calcium - metabolism Catecholamines - metabolism Cell Differentiation Colforsin - metabolism Cyclic AMP - metabolism Electrocardiography Heterozygote Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Karyotyping Models, Biological Mutation Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Original Paper Patch-Clamp Techniques Phenotype Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism Tachycardia, Ventricular - metabolism Tachycardia, Ventricular - pathology
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