Topoisomerase Mutations That Are Associated with High-Level Resistance to Earlier Fluoroquinolones in Staphylococcus aureus Have Less Effect on the Antibacterial Activity of Besifloxacin

Background: The impact of mutations in DNA gyrase and topoisomerase IV on minimum inhibitory concentrations (MICs) was investigated to better understand why besifloxacin has a higher potency against Staphylococcus aureus when compared to other fluoroquinolones, which was especially pronounced agains...

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Veröffentlicht in:	Chemotherapy (Basel) 2011-01, Vol.57 (5), p.363-371
Hauptverfasser:	Sanfilippo, Christine M., Hesje, Christine K., Haas, Wolfgang, Morris, Timothy W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Azepines - pharmacology Bacteria DNA Gyrase - genetics DNA Topoisomerase IV - genetics Dose-Response Relationship, Drug Drug resistance Drug Resistance, Multiple, Bacterial - genetics Drug therapy Fluoroquinolones - pharmacology Microbial Sensitivity Tests Microbiology Mutation Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - genetics Staphylococcus infections
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