Self-Organization Phenomena in Embryonic Stem Cell-Derived Embryoid Bodies: Axis Formation and Breaking of Symmetry during Cardiomyogenesis

Aggregation of embryonic stem cells gives rise to embryoid bodies (EBs) which undergo developmental processes reminiscent of early eutherian embryonic development. Development of the three germ layers suggests that gastrulation takes place. In vivo, gastrulation is a highly ordered process but in EB...

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Veröffentlicht in:	Cells, tissues, organs tissues, organs, 2012-04, Vol.195 (5), p.377-391
Hauptverfasser:	Fuchs, Christiane, Scheinast, Matthias, Pasteiner, Waltraud, Lagger, Sabine, Hofner, Manuela, Hoellrigl, Alexandra, Schultheis, Martina, Weitzer, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetry cardiomyocytes Cytology Data processing Desmin Differentiation Embryo cells Embryogenesis Embryoid Bodies - cytology Embryoid Bodies - metabolism Embryonic Development Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Gastrulation Heart Humans Mesoderm Microscopy, Confocal Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Organogenesis - physiology Original Paper Stem cells
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