Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass Surgery
Thirty-five morbidly obese patients underwent Roux-en-Y gastric bypass surgery (RYGB). In addition to weight loss, these patients showed significant improvement of insulin resistance and a reduction of hepatic fat content. Three months after surgery, the serum bile salts were slightly but significan...
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| Veröffentlicht in: | Digestive diseases (Basel) 2011-01, Vol.29 (1), p.48-51 |
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| container_title | Digestive diseases (Basel) |
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| creator | Jansen, Peter L.M. van Werven, Jochem Aarts, Edo Berends, Frits Janssen, Ignace Stoker, Jaap Schaap, Frank G. |
| description | Thirty-five morbidly obese patients underwent Roux-en-Y gastric bypass surgery (RYGB). In addition to weight loss, these patients showed significant improvement of insulin resistance and a reduction of hepatic fat content. Three months after surgery, the serum bile salts were slightly but significantly elevated, and the levels of the endocrine-acting fibroblast growth factor 19 (FGF19) and FGF21 were increased. FGF19 and FGF21 play a role as regulators of hepatic lipid and glucose metabolism. These results show that RYGB surgery improves metabolism and that this improvement is still apparent 3 months after surgery. Bile salts may play a key role in the improvement of metabolism after RYGB. Why serum bile salt concentrations are elevated after RYGB needs to be investigated. |
| doi_str_mv | 10.1159/000324128 |
| format | Article |
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In addition to weight loss, these patients showed significant improvement of insulin resistance and a reduction of hepatic fat content. Three months after surgery, the serum bile salts were slightly but significantly elevated, and the levels of the endocrine-acting fibroblast growth factor 19 (FGF19) and FGF21 were increased. FGF19 and FGF21 play a role as regulators of hepatic lipid and glucose metabolism. These results show that RYGB surgery improves metabolism and that this improvement is still apparent 3 months after surgery. Bile salts may play a key role in the improvement of metabolism after RYGB. 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In addition to weight loss, these patients showed significant improvement of insulin resistance and a reduction of hepatic fat content. Three months after surgery, the serum bile salts were slightly but significantly elevated, and the levels of the endocrine-acting fibroblast growth factor 19 (FGF19) and FGF21 were increased. FGF19 and FGF21 play a role as regulators of hepatic lipid and glucose metabolism. These results show that RYGB surgery improves metabolism and that this improvement is still apparent 3 months after surgery. Bile salts may play a key role in the improvement of metabolism after RYGB. Why serum bile salt concentrations are elevated after RYGB needs to be investigated.</description><subject>Bile Acids and Salts - blood</subject><subject>Fibroblast Growth Factors - blood</subject><subject>Gastric Bypass</subject><subject>Humans</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - surgery</subject><subject>Receptor Regulation by Bile Acids</subject><issn>0257-2753</issn><issn>1421-9875</issn><isbn>3805597274</isbn><isbn>9783805597272</isbn><isbn>9783805597289</isbn><isbn>3805597282</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90ElPwzAQBWCziZblwB0h3xCHgJc4to8F0RapEhLLgVM0dh0IpHWxEyD_nlRdTnOYb540D6EzSq4pFfqGEMJZSpnaQadaKq6IEFoypXdRn6aMJlpJsYeONguZ7qM-YUImTAreQ0cxfhLSJcnsEPUYzTSlJO0jGFS1C1CXfh6xL_DYh5mfQ1W1eGDr8sfhYWmCNxXEGo-C_60_8BBs7UPEUHSn-Mk3f4mbJ2941JlQWnzbLiBG_NyEdxfaE3RQQBXd6Xoeo9fh_cvdOJk8jh7uBpPEciLqhAFk0mhIRWYcl444XjCdWkPd1EhHqRZWKJWlDNQ0swoEN1RbcNZkUrApP0aXq9xF8N-Ni3U-K6N1VQVz55uYK8k5FYyzTl6tpA0-xuCKfBHKGYQ2pyRftp1v2-7sxTq1MTM33cpNgx04X4EvWL67Bev7f_Bhfrc</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Jansen, Peter L.M.</creator><creator>van Werven, Jochem</creator><creator>Aarts, Edo</creator><creator>Berends, Frits</creator><creator>Janssen, Ignace</creator><creator>Stoker, Jaap</creator><creator>Schaap, Frank G.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110101</creationdate><title>Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass Surgery</title><author>Jansen, Peter L.M. ; van Werven, Jochem ; Aarts, Edo ; Berends, Frits ; Janssen, Ignace ; Stoker, Jaap ; Schaap, Frank G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-2aa67b9a456be37e0e3f294cb1edb7e1195c588642a8d6c8a53b19caecb6752d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Bile Acids and Salts - blood</topic><topic>Fibroblast Growth Factors - blood</topic><topic>Gastric Bypass</topic><topic>Humans</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - surgery</topic><topic>Receptor Regulation by Bile Acids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jansen, Peter L.M.</creatorcontrib><creatorcontrib>van Werven, Jochem</creatorcontrib><creatorcontrib>Aarts, Edo</creatorcontrib><creatorcontrib>Berends, Frits</creatorcontrib><creatorcontrib>Janssen, Ignace</creatorcontrib><creatorcontrib>Stoker, Jaap</creatorcontrib><creatorcontrib>Schaap, Frank G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jansen, Peter L.M.</au><au>van Werven, Jochem</au><au>Aarts, Edo</au><au>Berends, Frits</au><au>Janssen, Ignace</au><au>Stoker, Jaap</au><au>Schaap, Frank G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass Surgery</atitle><jtitle>Digestive diseases (Basel)</jtitle><addtitle>Dig Dis</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>29</volume><issue>1</issue><spage>48</spage><epage>51</epage><pages>48-51</pages><issn>0257-2753</issn><eissn>1421-9875</eissn><isbn>3805597274</isbn><isbn>9783805597272</isbn><eisbn>9783805597289</eisbn><eisbn>3805597282</eisbn><abstract>Thirty-five morbidly obese patients underwent Roux-en-Y gastric bypass surgery (RYGB). 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| ispartof | Digestive diseases (Basel), 2011-01, Vol.29 (1), p.48-51 |
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| language | eng |
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| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Bile Acids and Salts - blood Fibroblast Growth Factors - blood Gastric Bypass Humans Obesity, Morbid - blood Obesity, Morbid - surgery Receptor Regulation by Bile Acids |
| title | Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass Surgery |
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