Correlation between Serum Immunoglobulin G and Hearing Threshold among Elderly Subjects with Age-Related Hearing Loss
Background and Purpose: This study was based on the hypothesis that suboptimal immune response and low serum immunoglobulin G (IgG) may predispose to age-related hearing loss (ARHL), and the objective was to determine the serum levels of IgG and hearing thresholds of apparently healthy elderly subje...
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| Veröffentlicht in: | O.R.L. Journal for oto-rhino-laryngology and its related specialties 2011-01, Vol.73 (2), p.88-92 |
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| container_title | O.R.L. Journal for oto-rhino-laryngology and its related specialties |
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| creator | Lasisi, Akeem Olawale Fehintola, Fatai A. Yusuf, Oyindamola Bidemi Olayemi, Oladapo O. |
| description | Background and Purpose: This study was based on the hypothesis that suboptimal immune response and low serum immunoglobulin G (IgG) may predispose to age-related hearing loss (ARHL), and the objective was to determine the serum levels of IgG and hearing thresholds of apparently healthy elderly subjects and assess their correlation. Method: This prospective study involved 126 participants ≧60 years old who were found to be free of any medical conditions. Pure-tone averages for both the speech (500–2,000 Hz) and high frequencies (3,000–8,000 Hz) and serum IgG levels were determined. Using 30 dB as cut-off for hearing loss, the correlation with serum IgG was assessed. Results: There were 59 males and 67 females with a mean age ± SD of 67.0 ± 2.7 years. Speech frequency hearing loss was seen in 30.2%, while high-frequency hearing loss accounted for 74.6%. In the speech frequencies, the mean ± SD of serum IgG among subjects with normal hearing was 11.3 ± 3.9 g/l, while among those with hearing loss it was 8.3 ± 3.3 g/l (p = 0.01). In the high frequencies, the mean ± SD values of serum IgG among the subjects with normal hearing was 11.1 ± 2.3 g/l, while among those with hearing loss it was 8.7 ± 1.9 g/l (p = 0.01). Conclusion: Low serum IgG may be a contributory factor to the development of ARHL among the elderly. However, a longitudinal study involving intervention with immunoglobulin supplementation may further confirm this role. |
| doi_str_mv | 10.1159/000323830 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_karger_primary_323830</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>859494421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-4f655dec5b5aca321f920ca78ca5c21c8ec06c5831889c13982661bd61ed037a3</originalsourceid><addsrcrecordid>eNpd0c9LHDEUB_BQLHW79eBdJAhSehjNj8lMcpTFqrBQUHseMpk3u7NmEk0miP-9kd2u0FMIfN43ee8hdEzJBaVCXRJCOOOSky9oRkvGC8JqcYBmhBNaUFGpQ_Q9xk1mgsn6GzpklJOSsXKG0sKHAFZPg3e4hekVwOEHCGnEd-OYnF9Z3yY7OHyDtevwLegwuBV-XAeIa287rEef79e2g2Df8ENqN2CmiF-HaY2vVlDcf6TDZ-XSx_gDfe21jXC0O-fo7-_rx8Vtsfxzc7e4WhaGV2wqyr4SogMjWqGN5oz2ihGja2m0MIwaCYZURkhOpVSGciVZVdG2qyh0hNeaz9HPbe5z8C8J4tSMQzRgrXbgU2ykUKUqyzyOOTr7T258Ci5_rpF1RXK-Ehn92iITchMB-uY5DKMObw0lzccmmv0msj3dBaZ2hG4v_40-g_Md0NFo2wftzBA_XUmYklRmd7J1TzqsIOzB7p134rWYlw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>876088995</pqid></control><display><type>article</type><title>Correlation between Serum Immunoglobulin G and Hearing Threshold among Elderly Subjects with Age-Related Hearing Loss</title><source>MEDLINE</source><source>Karger Journals</source><source>Alma/SFX Local Collection</source><source>Karger:Jisc Collections:ORL, Ophthalmology, Dental Medicine, Obstetrics, Gynecology and Psychology, Psychiatry Archive Collection (2012-2112)</source><creator>Lasisi, Akeem Olawale ; Fehintola, Fatai A. ; Yusuf, Oyindamola Bidemi ; Olayemi, Oladapo O.</creator><creatorcontrib>Lasisi, Akeem Olawale ; Fehintola, Fatai A. ; Yusuf, Oyindamola Bidemi ; Olayemi, Oladapo O.</creatorcontrib><description>Background and Purpose: This study was based on the hypothesis that suboptimal immune response and low serum immunoglobulin G (IgG) may predispose to age-related hearing loss (ARHL), and the objective was to determine the serum levels of IgG and hearing thresholds of apparently healthy elderly subjects and assess their correlation. Method: This prospective study involved 126 participants ≧60 years old who were found to be free of any medical conditions. Pure-tone averages for both the speech (500–2,000 Hz) and high frequencies (3,000–8,000 Hz) and serum IgG levels were determined. Using 30 dB as cut-off for hearing loss, the correlation with serum IgG was assessed. Results: There were 59 males and 67 females with a mean age ± SD of 67.0 ± 2.7 years. Speech frequency hearing loss was seen in 30.2%, while high-frequency hearing loss accounted for 74.6%. In the speech frequencies, the mean ± SD of serum IgG among subjects with normal hearing was 11.3 ± 3.9 g/l, while among those with hearing loss it was 8.3 ± 3.3 g/l (p = 0.01). In the high frequencies, the mean ± SD values of serum IgG among the subjects with normal hearing was 11.1 ± 2.3 g/l, while among those with hearing loss it was 8.7 ± 1.9 g/l (p = 0.01). Conclusion: Low serum IgG may be a contributory factor to the development of ARHL among the elderly. However, a longitudinal study involving intervention with immunoglobulin supplementation may further confirm this role.</description><identifier>ISSN: 0301-1569</identifier><identifier>EISSN: 1423-0275</identifier><identifier>DOI: 10.1159/000323830</identifier><identifier>PMID: 21304224</identifier><identifier>CODEN: ORLJAH</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Aged ; Aging ; Audiometry, Pure-Tone ; Auditory Threshold - physiology ; Biological and medical sciences ; Biomarkers - blood ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; Ears & hearing ; Female ; Hearing loss ; Humans ; Immunoglobulin G - blood ; Immunoglobulins ; Linear Models ; Male ; Medical sciences ; Non tumoral diseases ; Older people ; Original Paper ; Otorhinolaryngology. Stomatology ; Presbycusis - diagnosis ; Presbycusis - immunology ; Presbycusis - physiopathology ; Prospective Studies</subject><ispartof>O.R.L. 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Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-4f655dec5b5aca321f920ca78ca5c21c8ec06c5831889c13982661bd61ed037a3</citedby><cites>FETCH-LOGICAL-c362t-4f655dec5b5aca321f920ca78ca5c21c8ec06c5831889c13982661bd61ed037a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24029818$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21304224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lasisi, Akeem Olawale</creatorcontrib><creatorcontrib>Fehintola, Fatai A.</creatorcontrib><creatorcontrib>Yusuf, Oyindamola Bidemi</creatorcontrib><creatorcontrib>Olayemi, Oladapo O.</creatorcontrib><title>Correlation between Serum Immunoglobulin G and Hearing Threshold among Elderly Subjects with Age-Related Hearing Loss</title><title>O.R.L. Journal for oto-rhino-laryngology and its related specialties</title><addtitle>ORL</addtitle><description>Background and Purpose: This study was based on the hypothesis that suboptimal immune response and low serum immunoglobulin G (IgG) may predispose to age-related hearing loss (ARHL), and the objective was to determine the serum levels of IgG and hearing thresholds of apparently healthy elderly subjects and assess their correlation. Method: This prospective study involved 126 participants ≧60 years old who were found to be free of any medical conditions. Pure-tone averages for both the speech (500–2,000 Hz) and high frequencies (3,000–8,000 Hz) and serum IgG levels were determined. Using 30 dB as cut-off for hearing loss, the correlation with serum IgG was assessed. Results: There were 59 males and 67 females with a mean age ± SD of 67.0 ± 2.7 years. Speech frequency hearing loss was seen in 30.2%, while high-frequency hearing loss accounted for 74.6%. In the speech frequencies, the mean ± SD of serum IgG among subjects with normal hearing was 11.3 ± 3.9 g/l, while among those with hearing loss it was 8.3 ± 3.3 g/l (p = 0.01). In the high frequencies, the mean ± SD values of serum IgG among the subjects with normal hearing was 11.1 ± 2.3 g/l, while among those with hearing loss it was 8.7 ± 1.9 g/l (p = 0.01). Conclusion: Low serum IgG may be a contributory factor to the development of ARHL among the elderly. However, a longitudinal study involving intervention with immunoglobulin supplementation may further confirm this role.</description><subject>Aged</subject><subject>Aging</subject><subject>Audiometry, Pure-Tone</subject><subject>Auditory Threshold - physiology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</subject><subject>Ears & hearing</subject><subject>Female</subject><subject>Hearing loss</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulins</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Older people</subject><subject>Original Paper</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Presbycusis - diagnosis</subject><subject>Presbycusis - immunology</subject><subject>Presbycusis - physiopathology</subject><subject>Prospective Studies</subject><issn>0301-1569</issn><issn>1423-0275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0c9LHDEUB_BQLHW79eBdJAhSehjNj8lMcpTFqrBQUHseMpk3u7NmEk0miP-9kd2u0FMIfN43ee8hdEzJBaVCXRJCOOOSky9oRkvGC8JqcYBmhBNaUFGpQ_Q9xk1mgsn6GzpklJOSsXKG0sKHAFZPg3e4hekVwOEHCGnEd-OYnF9Z3yY7OHyDtevwLegwuBV-XAeIa287rEef79e2g2Df8ENqN2CmiF-HaY2vVlDcf6TDZ-XSx_gDfe21jXC0O-fo7-_rx8Vtsfxzc7e4WhaGV2wqyr4SogMjWqGN5oz2ihGja2m0MIwaCYZURkhOpVSGciVZVdG2qyh0hNeaz9HPbe5z8C8J4tSMQzRgrXbgU2ykUKUqyzyOOTr7T258Ci5_rpF1RXK-Ehn92iITchMB-uY5DKMObw0lzccmmv0msj3dBaZ2hG4v_40-g_Md0NFo2wftzBA_XUmYklRmd7J1TzqsIOzB7p134rWYlw</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Lasisi, Akeem Olawale</creator><creator>Fehintola, Fatai A.</creator><creator>Yusuf, Oyindamola Bidemi</creator><creator>Olayemi, Oladapo O.</creator><general>Karger</general><general>S. 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Stomatology</topic><topic>Presbycusis - diagnosis</topic><topic>Presbycusis - immunology</topic><topic>Presbycusis - physiopathology</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lasisi, Akeem Olawale</creatorcontrib><creatorcontrib>Fehintola, Fatai A.</creatorcontrib><creatorcontrib>Yusuf, Oyindamola Bidemi</creatorcontrib><creatorcontrib>Olayemi, Oladapo O.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>O.R.L. Journal for oto-rhino-laryngology and its related specialties</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lasisi, Akeem Olawale</au><au>Fehintola, Fatai A.</au><au>Yusuf, Oyindamola Bidemi</au><au>Olayemi, Oladapo O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between Serum Immunoglobulin G and Hearing Threshold among Elderly Subjects with Age-Related Hearing Loss</atitle><jtitle>O.R.L. Journal for oto-rhino-laryngology and its related specialties</jtitle><addtitle>ORL</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>73</volume><issue>2</issue><spage>88</spage><epage>92</epage><pages>88-92</pages><issn>0301-1569</issn><eissn>1423-0275</eissn><coden>ORLJAH</coden><abstract>Background and Purpose: This study was based on the hypothesis that suboptimal immune response and low serum immunoglobulin G (IgG) may predispose to age-related hearing loss (ARHL), and the objective was to determine the serum levels of IgG and hearing thresholds of apparently healthy elderly subjects and assess their correlation. Method: This prospective study involved 126 participants ≧60 years old who were found to be free of any medical conditions. Pure-tone averages for both the speech (500–2,000 Hz) and high frequencies (3,000–8,000 Hz) and serum IgG levels were determined. Using 30 dB as cut-off for hearing loss, the correlation with serum IgG was assessed. Results: There were 59 males and 67 females with a mean age ± SD of 67.0 ± 2.7 years. Speech frequency hearing loss was seen in 30.2%, while high-frequency hearing loss accounted for 74.6%. In the speech frequencies, the mean ± SD of serum IgG among subjects with normal hearing was 11.3 ± 3.9 g/l, while among those with hearing loss it was 8.3 ± 3.3 g/l (p = 0.01). In the high frequencies, the mean ± SD values of serum IgG among the subjects with normal hearing was 11.1 ± 2.3 g/l, while among those with hearing loss it was 8.7 ± 1.9 g/l (p = 0.01). Conclusion: Low serum IgG may be a contributory factor to the development of ARHL among the elderly. However, a longitudinal study involving intervention with immunoglobulin supplementation may further confirm this role.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>21304224</pmid><doi>10.1159/000323830</doi><tpages>5</tpages></addata></record> |
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| ispartof | O.R.L. Journal for oto-rhino-laryngology and its related specialties, 2011-01, Vol.73 (2), p.88-92 |
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| source | MEDLINE; Karger Journals; Alma/SFX Local Collection; Karger:Jisc Collections:ORL, Ophthalmology, Dental Medicine, Obstetrics, Gynecology and Psychology, Psychiatry Archive Collection (2012-2112) |
| subjects | Aged Aging Audiometry, Pure-Tone Auditory Threshold - physiology Biological and medical sciences Biomarkers - blood Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ears & hearing Female Hearing loss Humans Immunoglobulin G - blood Immunoglobulins Linear Models Male Medical sciences Non tumoral diseases Older people Original Paper Otorhinolaryngology. Stomatology Presbycusis - diagnosis Presbycusis - immunology Presbycusis - physiopathology Prospective Studies |
| title | Correlation between Serum Immunoglobulin G and Hearing Threshold among Elderly Subjects with Age-Related Hearing Loss |
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