Early Phase of Allergic Airway Inflammation in Diabetic Rats: Role of Insulin on the Signaling Pathways and Mediators

Background: Allergic lung inflammation is impaired in diabetic rats and is restored by insulin treatment. In the present study we investigated the effect of insulin on the signaling pathways triggered by allergic inflammation in the lung and the release of selected mediators. Methods: Diabetic male...

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Veröffentlicht in:	Cellular physiology and biochemistry 2010-01, Vol.26 (4-5), p.739-748
Hauptverfasser:	Martins, Joilson O., Wittlin, Beatriz M., Anger, Denise B.C., Martins, Daniel O., Sannomiya, Paulina, Jancar, Sonia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum Oxide - chemistry Animals Bronchoalveolar Lavage Fluid Chemokines, CXC - metabolism Diabetes Mellitus, Experimental - metabolism Dinoprostone - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Insulin - pharmacology Insulin - physiology Interleukin-6 - metabolism Male Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Original Paper Ovalbumin - immunology Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Pneumonia - metabolism Protein Kinase C-alpha - metabolism Protein Kinase C-delta - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar Signal Transduction
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