Ethyl Chloride as an Antipruritic Agent: A Double-Blind Placebo-Controlled Prospective Study
Background: Ethyl chloride (EC) is usually used as a topical anesthetic spray agent. However, its antipruritic effects have never been studied, to the best of our knowledge. Methods: A double-blind placebo-controlled prospective study. Overall, 51 healthy volunteers underwent a histamine skin prick...
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| Veröffentlicht in: | Dermatology (Basel) 2010-01, Vol.221 (4), p.373-377 |
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| creator | Gal-Oz, Amir Rogowski, Ori Swartzon, Michael Kivity, Shmuel |
| description | Background: Ethyl chloride (EC) is usually used as a topical anesthetic spray agent. However, its antipruritic effects have never been studied, to the best of our knowledge. Methods: A double-blind placebo-controlled prospective study. Overall, 51 healthy volunteers underwent a histamine skin prick test on both arms in order to trigger local pruritus. Thereafter, the affected areas were treated with an EC spray on one arm and a saline spray (placebo) on the other. Subjects as well as researchers were blind to which sprays were used. Subjects reported improvement in pruritus following EC/placebo and rated the intensity of pruritus by using a validated questionnaire and a visual analog scale. The flare and wheal reactions were measured in both arms before and following treatment with EC/placebo. Results: Significant improvement in pruritus was reported more frequently following treatment with EC compared with placebo (84 vs. 16%; p < 0.0001). Significant reduction in pruritus intensity was reported immediately and 15 min following treatment with EC compared with placebo (p < 0.05). There was no significant difference between EC and placebo in terms of the flare and wheal reactions. Conclusions: EC is an effective antipruritic agent, and it does not change the wheal and flare reactions, making it ideal for treating pruritus secondary to allergy skin tests without masking their results. |
| doi_str_mv | 10.1159/000321720 |
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However, its antipruritic effects have never been studied, to the best of our knowledge. Methods: A double-blind placebo-controlled prospective study. Overall, 51 healthy volunteers underwent a histamine skin prick test on both arms in order to trigger local pruritus. Thereafter, the affected areas were treated with an EC spray on one arm and a saline spray (placebo) on the other. Subjects as well as researchers were blind to which sprays were used. Subjects reported improvement in pruritus following EC/placebo and rated the intensity of pruritus by using a validated questionnaire and a visual analog scale. The flare and wheal reactions were measured in both arms before and following treatment with EC/placebo. Results: Significant improvement in pruritus was reported more frequently following treatment with EC compared with placebo (84 vs. 16%; p < 0.0001). Significant reduction in pruritus intensity was reported immediately and 15 min following treatment with EC compared with placebo (p < 0.05). There was no significant difference between EC and placebo in terms of the flare and wheal reactions. Conclusions: EC is an effective antipruritic agent, and it does not change the wheal and flare reactions, making it ideal for treating pruritus secondary to allergy skin tests without masking their results.</description><identifier>ISSN: 1018-8665</identifier><identifier>EISSN: 1421-9832</identifier><identifier>DOI: 10.1159/000321720</identifier><identifier>PMID: 21099198</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Anesthesia ; Antipruritics - therapeutic use ; Biological and medical sciences ; Clinical outcomes ; Clinical trials ; Dermatology ; Double-Blind Method ; Drug therapy ; Ethyl Chloride - therapeutic use ; Female ; Histamine - adverse effects ; Humans ; Male ; Medical sciences ; Middle Aged ; Original Paper ; Pain Measurement ; Pruritus - drug therapy ; Skin diseases ; Skin Irritancy Tests ; Young Adult</subject><ispartof>Dermatology (Basel), 2010-01, Vol.221 (4), p.373-377</ispartof><rights>2010 S. Karger AG, Basel</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2010 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-cbb1c8ebf6f5c6c2c38665773b1f02634bd54682a13315381e259a0feb994b4d3</citedby><cites>FETCH-LOGICAL-c362t-cbb1c8ebf6f5c6c2c38665773b1f02634bd54682a13315381e259a0feb994b4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,2431,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23687065$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21099198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gal-Oz, Amir</creatorcontrib><creatorcontrib>Rogowski, Ori</creatorcontrib><creatorcontrib>Swartzon, Michael</creatorcontrib><creatorcontrib>Kivity, Shmuel</creatorcontrib><title>Ethyl Chloride as an Antipruritic Agent: A Double-Blind Placebo-Controlled Prospective Study</title><title>Dermatology (Basel)</title><addtitle>Dermatology</addtitle><description>Background: Ethyl chloride (EC) is usually used as a topical anesthetic spray agent. However, its antipruritic effects have never been studied, to the best of our knowledge. Methods: A double-blind placebo-controlled prospective study. Overall, 51 healthy volunteers underwent a histamine skin prick test on both arms in order to trigger local pruritus. Thereafter, the affected areas were treated with an EC spray on one arm and a saline spray (placebo) on the other. Subjects as well as researchers were blind to which sprays were used. Subjects reported improvement in pruritus following EC/placebo and rated the intensity of pruritus by using a validated questionnaire and a visual analog scale. The flare and wheal reactions were measured in both arms before and following treatment with EC/placebo. Results: Significant improvement in pruritus was reported more frequently following treatment with EC compared with placebo (84 vs. 16%; p < 0.0001). Significant reduction in pruritus intensity was reported immediately and 15 min following treatment with EC compared with placebo (p < 0.05). There was no significant difference between EC and placebo in terms of the flare and wheal reactions. Conclusions: EC is an effective antipruritic agent, and it does not change the wheal and flare reactions, making it ideal for treating pruritus secondary to allergy skin tests without masking their results.</description><subject>Adult</subject><subject>Anesthesia</subject><subject>Antipruritics - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Clinical outcomes</subject><subject>Clinical trials</subject><subject>Dermatology</subject><subject>Double-Blind Method</subject><subject>Drug therapy</subject><subject>Ethyl Chloride - therapeutic use</subject><subject>Female</subject><subject>Histamine - adverse effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Pain Measurement</subject><subject>Pruritus - drug therapy</subject><subject>Skin diseases</subject><subject>Skin Irritancy Tests</subject><subject>Young Adult</subject><issn>1018-8665</issn><issn>1421-9832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0N9rFDEQB_BQlLbWPvguEgQRH7bmxyab-HaeVQsFBdu3wpJkZ9vU3OZMssL99-a48wSfJgwfZiZfhF5QckGp0O8JIZzRjpEjdEpbRhutOHtS34SqRkkpTtCznB8rY6rTx-iEUaI11eoU3V2Wh03Ay4cQkx8Am4zNhBdT8es0J1-8w4t7mMoHvMCf4mwDNB-Dnwb8PRgHNjbLOJUUQ4DaSjGvwRX_G_CPMg-b5-jpaEKG8309Q7efL2-WX5vrb1-ulovrxnHJSuOspU6BHeUonHTM8e3NXcctHQmTvLWDaKVihnJOBVcUmNCGjGC1bm078DP0djd3neKvGXLpVz47CMFMEOfcK0apFkzIKl__Jx_jnKZ63BYxLTURFb3bIVc_lBOM_Tr5lUmbnpJ-G3h_CLzaV_uBs13BcJB_E67gzR6Y7EwYk5mcz_8cl6ojcrv05c79NOke0gHs9_wBHlyO1w</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Gal-Oz, Amir</creator><creator>Rogowski, Ori</creator><creator>Swartzon, Michael</creator><creator>Kivity, Shmuel</creator><general>Karger</general><general>S. 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Rogowski, Ori ; Swartzon, Michael ; Kivity, Shmuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-cbb1c8ebf6f5c6c2c38665773b1f02634bd54682a13315381e259a0feb994b4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Anesthesia</topic><topic>Antipruritics - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Clinical outcomes</topic><topic>Clinical trials</topic><topic>Dermatology</topic><topic>Double-Blind Method</topic><topic>Drug therapy</topic><topic>Ethyl Chloride - therapeutic use</topic><topic>Female</topic><topic>Histamine - adverse effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Pain Measurement</topic><topic>Pruritus - drug therapy</topic><topic>Skin diseases</topic><topic>Skin Irritancy Tests</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gal-Oz, Amir</creatorcontrib><creatorcontrib>Rogowski, Ori</creatorcontrib><creatorcontrib>Swartzon, Michael</creatorcontrib><creatorcontrib>Kivity, Shmuel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gal-Oz, Amir</au><au>Rogowski, Ori</au><au>Swartzon, Michael</au><au>Kivity, Shmuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethyl Chloride as an Antipruritic Agent: A Double-Blind Placebo-Controlled Prospective Study</atitle><jtitle>Dermatology (Basel)</jtitle><addtitle>Dermatology</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>221</volume><issue>4</issue><spage>373</spage><epage>377</epage><pages>373-377</pages><issn>1018-8665</issn><eissn>1421-9832</eissn><abstract>Background: Ethyl chloride (EC) is usually used as a topical anesthetic spray agent. However, its antipruritic effects have never been studied, to the best of our knowledge. Methods: A double-blind placebo-controlled prospective study. Overall, 51 healthy volunteers underwent a histamine skin prick test on both arms in order to trigger local pruritus. Thereafter, the affected areas were treated with an EC spray on one arm and a saline spray (placebo) on the other. Subjects as well as researchers were blind to which sprays were used. Subjects reported improvement in pruritus following EC/placebo and rated the intensity of pruritus by using a validated questionnaire and a visual analog scale. The flare and wheal reactions were measured in both arms before and following treatment with EC/placebo. Results: Significant improvement in pruritus was reported more frequently following treatment with EC compared with placebo (84 vs. 16%; p < 0.0001). Significant reduction in pruritus intensity was reported immediately and 15 min following treatment with EC compared with placebo (p < 0.05). There was no significant difference between EC and placebo in terms of the flare and wheal reactions. Conclusions: EC is an effective antipruritic agent, and it does not change the wheal and flare reactions, making it ideal for treating pruritus secondary to allergy skin tests without masking their results.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>21099198</pmid><doi>10.1159/000321720</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Anesthesia Antipruritics - therapeutic use Biological and medical sciences Clinical outcomes Clinical trials Dermatology Double-Blind Method Drug therapy Ethyl Chloride - therapeutic use Female Histamine - adverse effects Humans Male Medical sciences Middle Aged Original Paper Pain Measurement Pruritus - drug therapy Skin diseases Skin Irritancy Tests Young Adult |
| title | Ethyl Chloride as an Antipruritic Agent: A Double-Blind Placebo-Controlled Prospective Study |
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