Validation and Clinical Use of the Japanese Classification of Colorectal Carcinomatosis: Benefit of Surgical Cytoreduction Even without Hyperthermic Intraperitoneal Chemotherapy
Background: This study aimed to validate an easy to use practical classification of peritoneal metastasis arising from colorectal cancer. Patients and Methods: Data from 2,134 consecutive patients who underwent resection for colorectal cancer at a single institution were reviewed. Peritoneal metasta...
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| Veröffentlicht in: | Digestive surgery 2010-01, Vol.27 (6), p.473-480 |
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| creator | Kobayashi, Hirotoshi Enomoto, Masayuki Higuchi, Tetsuro Uetake, Hiroyuki Iida, Satoru Ishikawa, Toshiaki Ishiguro, Megumi Sugihara, Kenichi |
| description | Background: This study aimed to validate an easy to use practical classification of peritoneal metastasis arising from colorectal cancer. Patients and Methods: Data from 2,134 consecutive patients who underwent resection for colorectal cancer at a single institution were reviewed. Peritoneal metastasis was classified depending on extent into three groups (P1–P3). The macroscopic radical resection rates and survival of patients with colorectal cancer complicated with peritoneal metastasis were analyzed. Results: Of the 2,134 patients, 116 (5.4%) had peritoneal metastasis. Among them, 20 (17.2%) underwent macroscopic radical resection. Tumor location on the right side was associated with more extensive peritoneal metastasis (p = 0.010). Male gender (p = 0.0027), liver metastasis (p = 0.0021), and P3 peritoneal metastasis were independent risk factors for noncurative resection. The Cox proportional hazards model showed that gender (p = 0.031), operation period (p = 0.031), and macroscopic radical resection for colorectal cancer and peritoneal metastasis (p = 0.031) were independent prognostic factors. Conclusions: Being female with left colon cancer complicated with P1 or P2 peritoneal metastasis is a good indicator for macroscopic radical resection if liver metastasis is absent. The present classification helped to determine surgical indication for patients with colorectal cancer complicated with synchronous peritoneal metastasis in routine clinical practice. |
| doi_str_mv | 10.1159/000320460 |
| format | Article |
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Patients and Methods: Data from 2,134 consecutive patients who underwent resection for colorectal cancer at a single institution were reviewed. Peritoneal metastasis was classified depending on extent into three groups (P1–P3). The macroscopic radical resection rates and survival of patients with colorectal cancer complicated with peritoneal metastasis were analyzed. Results: Of the 2,134 patients, 116 (5.4%) had peritoneal metastasis. Among them, 20 (17.2%) underwent macroscopic radical resection. Tumor location on the right side was associated with more extensive peritoneal metastasis (p = 0.010). Male gender (p = 0.0027), liver metastasis (p = 0.0021), and P3 peritoneal metastasis were independent risk factors for noncurative resection. The Cox proportional hazards model showed that gender (p = 0.031), operation period (p = 0.031), and macroscopic radical resection for colorectal cancer and peritoneal metastasis (p = 0.031) were independent prognostic factors. Conclusions: Being female with left colon cancer complicated with P1 or P2 peritoneal metastasis is a good indicator for macroscopic radical resection if liver metastasis is absent. The present classification helped to determine surgical indication for patients with colorectal cancer complicated with synchronous peritoneal metastasis in routine clinical practice.</description><identifier>ISSN: 0253-4886</identifier><identifier>EISSN: 1421-9883</identifier><identifier>DOI: 10.1159/000320460</identifier><identifier>PMID: 21063124</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Carcinoma - mortality ; Carcinoma - pathology ; Carcinoma - surgery ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Female ; Humans ; Japan ; Liver Neoplasms - secondary ; Male ; Middle Aged ; Original Paper ; Peritoneal Neoplasms - classification ; Peritoneal Neoplasms - drug therapy ; Peritoneal Neoplasms - secondary ; Prognosis ; Proportional Hazards Models ; Sex Factors</subject><ispartof>Digestive surgery, 2010-01, Vol.27 (6), p.473-480</ispartof><rights>2010 S. Karger AG, Basel</rights><rights>Copyright © 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-8449056340b2342dd0a92c8a82e2a9f6a02cf09816f7732c58a1aa325e2fbfce3</citedby><cites>FETCH-LOGICAL-c398t-8449056340b2342dd0a92c8a82e2a9f6a02cf09816f7732c58a1aa325e2fbfce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2422,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21063124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kobayashi, Hirotoshi</creatorcontrib><creatorcontrib>Enomoto, Masayuki</creatorcontrib><creatorcontrib>Higuchi, Tetsuro</creatorcontrib><creatorcontrib>Uetake, Hiroyuki</creatorcontrib><creatorcontrib>Iida, Satoru</creatorcontrib><creatorcontrib>Ishikawa, Toshiaki</creatorcontrib><creatorcontrib>Ishiguro, Megumi</creatorcontrib><creatorcontrib>Sugihara, Kenichi</creatorcontrib><title>Validation and Clinical Use of the Japanese Classification of Colorectal Carcinomatosis: Benefit of Surgical Cytoreduction Even without Hyperthermic Intraperitoneal Chemotherapy</title><title>Digestive surgery</title><addtitle>Dig Surg</addtitle><description>Background: This study aimed to validate an easy to use practical classification of peritoneal metastasis arising from colorectal cancer. Patients and Methods: Data from 2,134 consecutive patients who underwent resection for colorectal cancer at a single institution were reviewed. Peritoneal metastasis was classified depending on extent into three groups (P1–P3). The macroscopic radical resection rates and survival of patients with colorectal cancer complicated with peritoneal metastasis were analyzed. Results: Of the 2,134 patients, 116 (5.4%) had peritoneal metastasis. Among them, 20 (17.2%) underwent macroscopic radical resection. Tumor location on the right side was associated with more extensive peritoneal metastasis (p = 0.010). Male gender (p = 0.0027), liver metastasis (p = 0.0021), and P3 peritoneal metastasis were independent risk factors for noncurative resection. The Cox proportional hazards model showed that gender (p = 0.031), operation period (p = 0.031), and macroscopic radical resection for colorectal cancer and peritoneal metastasis (p = 0.031) were independent prognostic factors. Conclusions: Being female with left colon cancer complicated with P1 or P2 peritoneal metastasis is a good indicator for macroscopic radical resection if liver metastasis is absent. The present classification helped to determine surgical indication for patients with colorectal cancer complicated with synchronous peritoneal metastasis in routine clinical practice.</description><subject>Carcinoma - mortality</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - surgery</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Japan</subject><subject>Liver Neoplasms - secondary</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Peritoneal Neoplasms - classification</subject><subject>Peritoneal Neoplasms - drug therapy</subject><subject>Peritoneal Neoplasms - secondary</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Sex Factors</subject><issn>0253-4886</issn><issn>1421-9883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0U1v1DAQBmALgehSOHBHyOKCOAT8kXhtbhAVWlSJA5RrNOvYXZfETm0HtD-Lf4izu-yBkzWa5x1bHoSeU_KW0ka9I4RwRmpBHqAVrRmtlJT8IVoR1vCqllKcoScp3S1MKPoYnTFKBKesXqE_P2BwPWQXPAbf43Zw3mkY8E0yOFictwZ_gQm8KXU7QErOlv7el3YbhhCNziXQQtTOhxFySC69xx-NN9blRX2b4-1-aLvLhfez3ucvfhmPf7u8DXPGl7vJxHJbHJ3GVz5HKLXLwZsltzVjWJow7Z6iRxaGZJ4dz3N08-nie3tZXX_9fNV-uK40VzJXsq4VaQSvyYbxmvU9AcW0BMkMA2UFEKYtUZIKu15zphsJFICzxjC7sdrwc_T6MHeK4X42KXejS9oMQ_mLMKdO1kIRxteiyFf_ybswR18eV5BUTIqGF_TmgHQMKUVjuym6EeKuo6Rbttidtljsy-PAeTOa_iT_ra2AFwfwE-KtiSdwzP8FNWWjVg</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Kobayashi, Hirotoshi</creator><creator>Enomoto, Masayuki</creator><creator>Higuchi, Tetsuro</creator><creator>Uetake, Hiroyuki</creator><creator>Iida, Satoru</creator><creator>Ishikawa, Toshiaki</creator><creator>Ishiguro, Megumi</creator><creator>Sugihara, Kenichi</creator><general>S. 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Iida, Satoru ; Ishikawa, Toshiaki ; Ishiguro, Megumi ; Sugihara, Kenichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-8449056340b2342dd0a92c8a82e2a9f6a02cf09816f7732c58a1aa325e2fbfce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Carcinoma - mortality</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - surgery</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Japan</topic><topic>Liver Neoplasms - secondary</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Peritoneal Neoplasms - classification</topic><topic>Peritoneal Neoplasms - drug therapy</topic><topic>Peritoneal Neoplasms - secondary</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobayashi, Hirotoshi</creatorcontrib><creatorcontrib>Enomoto, Masayuki</creatorcontrib><creatorcontrib>Higuchi, Tetsuro</creatorcontrib><creatorcontrib>Uetake, Hiroyuki</creatorcontrib><creatorcontrib>Iida, Satoru</creatorcontrib><creatorcontrib>Ishikawa, Toshiaki</creatorcontrib><creatorcontrib>Ishiguro, Megumi</creatorcontrib><creatorcontrib>Sugihara, Kenichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobayashi, Hirotoshi</au><au>Enomoto, Masayuki</au><au>Higuchi, Tetsuro</au><au>Uetake, Hiroyuki</au><au>Iida, Satoru</au><au>Ishikawa, Toshiaki</au><au>Ishiguro, Megumi</au><au>Sugihara, Kenichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation and Clinical Use of the Japanese Classification of Colorectal Carcinomatosis: Benefit of Surgical Cytoreduction Even without Hyperthermic Intraperitoneal Chemotherapy</atitle><jtitle>Digestive surgery</jtitle><addtitle>Dig Surg</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>27</volume><issue>6</issue><spage>473</spage><epage>480</epage><pages>473-480</pages><issn>0253-4886</issn><eissn>1421-9883</eissn><abstract>Background: This study aimed to validate an easy to use practical classification of peritoneal metastasis arising from colorectal cancer. Patients and Methods: Data from 2,134 consecutive patients who underwent resection for colorectal cancer at a single institution were reviewed. Peritoneal metastasis was classified depending on extent into three groups (P1–P3). The macroscopic radical resection rates and survival of patients with colorectal cancer complicated with peritoneal metastasis were analyzed. Results: Of the 2,134 patients, 116 (5.4%) had peritoneal metastasis. Among them, 20 (17.2%) underwent macroscopic radical resection. Tumor location on the right side was associated with more extensive peritoneal metastasis (p = 0.010). Male gender (p = 0.0027), liver metastasis (p = 0.0021), and P3 peritoneal metastasis were independent risk factors for noncurative resection. The Cox proportional hazards model showed that gender (p = 0.031), operation period (p = 0.031), and macroscopic radical resection for colorectal cancer and peritoneal metastasis (p = 0.031) were independent prognostic factors. Conclusions: Being female with left colon cancer complicated with P1 or P2 peritoneal metastasis is a good indicator for macroscopic radical resection if liver metastasis is absent. The present classification helped to determine surgical indication for patients with colorectal cancer complicated with synchronous peritoneal metastasis in routine clinical practice.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>21063124</pmid><doi>10.1159/000320460</doi><tpages>8</tpages></addata></record> |
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| subjects | Carcinoma - mortality Carcinoma - pathology Carcinoma - surgery Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Female Humans Japan Liver Neoplasms - secondary Male Middle Aged Original Paper Peritoneal Neoplasms - classification Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - secondary Prognosis Proportional Hazards Models Sex Factors |
| title | Validation and Clinical Use of the Japanese Classification of Colorectal Carcinomatosis: Benefit of Surgical Cytoreduction Even without Hyperthermic Intraperitoneal Chemotherapy |
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