Normal-Weight 14-Year-Old Girl with Acanthosis Nigricans and Markedly Increased Hepatic Steatosis: Evidence for the Important Role of Ectopic Fat Deposition in the Pathogenesis of Insulin Resistance in Childhood and Adolescence
Background: A major factor in the development of insulin resistance is obesity. While the contribution of intrahepatic lipids to insulin resistance is well established in adults, there are only few reports in childhood and adolescence. Aim: To investigate the correlation between ectopic fat depositi...
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| Veröffentlicht in: | Hormone research in paediatrics 2010-01, Vol.74 (5), p.376-380 |
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| creator | Springer, Fabian Nguyen, Huu Phuc Machann, Jürgen Schweizer, Roland Ranke, Michael B. Binder, Gerhard Schick, Fritz Ehehalt, Stefan |
| description | Background: A major factor in the development of insulin resistance is obesity. While the contribution of intrahepatic lipids to insulin resistance is well established in adults, there are only few reports in childhood and adolescence. Aim: To investigate the correlation between ectopic fat deposition and insulin sensitivity in a normal-weight girl with acanthosis nigricans before and after lifestyle intervention. Methods: Variations in body fat composition and intrahepatic lipids were monitored by means of anthropometric measures and by means of methods based on magnetic resonance imaging and magnetic resonance spectroscopy. Results: We present the case of a normal-weight 14-year-old Caucasian girl with pronounced hepatic steatosis together with acanthosis nigricans, increased waist-circumference and increased visceral fat. During a 7-month period of lifestyle intervention, the girl lost 7.1 kg in weight. Acanthosis nigricans, whole-body insulin sensitivity index (WBISI) and homeostasis model assessment (HOMA) improved significantly (before intervention: WBISI 0.42, HOMA 22.2; after intervention: WBISI 1.35, HOMA 6.9). Even though all lipid compartments were decreased in size, the intrahepatic lipids showed an extraordinarily great reduction. Conclusion: This case presentation of a normal-weight girl with acanthosis nigricans and markedly increased hepatic steatosis provides support for the association between intrahepatic fat deposition and insulin resistance in adolescence. |
| doi_str_mv | 10.1159/000319707 |
| format | Article |
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While the contribution of intrahepatic lipids to insulin resistance is well established in adults, there are only few reports in childhood and adolescence. Aim: To investigate the correlation between ectopic fat deposition and insulin sensitivity in a normal-weight girl with acanthosis nigricans before and after lifestyle intervention. Methods: Variations in body fat composition and intrahepatic lipids were monitored by means of anthropometric measures and by means of methods based on magnetic resonance imaging and magnetic resonance spectroscopy. Results: We present the case of a normal-weight 14-year-old Caucasian girl with pronounced hepatic steatosis together with acanthosis nigricans, increased waist-circumference and increased visceral fat. During a 7-month period of lifestyle intervention, the girl lost 7.1 kg in weight. Acanthosis nigricans, whole-body insulin sensitivity index (WBISI) and homeostasis model assessment (HOMA) improved significantly (before intervention: WBISI 0.42, HOMA 22.2; after intervention: WBISI 1.35, HOMA 6.9). Even though all lipid compartments were decreased in size, the intrahepatic lipids showed an extraordinarily great reduction. Conclusion: This case presentation of a normal-weight girl with acanthosis nigricans and markedly increased hepatic steatosis provides support for the association between intrahepatic fat deposition and insulin resistance in adolescence.</description><identifier>ISSN: 1663-2818</identifier><identifier>EISSN: 1663-2826</identifier><identifier>DOI: 10.1159/000319707</identifier><identifier>PMID: 20847546</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Acanthosis Nigricans - complications ; Acanthosis Nigricans - metabolism ; Acanthosis Nigricans - pathology ; Adipose Tissue ; Adolescent ; Body Mass Index ; Body Weight - physiology ; Choristoma - pathology ; Diet ; Fatty Liver - complications ; Fatty Liver - pathology ; Female ; Humans ; Insulin resistance ; Insulin Resistance - physiology ; Life Style ; Motor Activity - physiology ; Novel Insights from Clinical Practice ; Puberty - physiology ; Waist-Hip Ratio</subject><ispartof>Hormone research in paediatrics, 2010-01, Vol.74 (5), p.376-380</ispartof><rights>2010 S. Karger AG, Basel</rights><rights>Copyright © 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2010 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c333t-45a8c6fe8d9949fc56d553b56b559c1076ed883be2eec0d1d845247947a132ba3</citedby><cites>FETCH-LOGICAL-c333t-45a8c6fe8d9949fc56d553b56b559c1076ed883be2eec0d1d845247947a132ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,2425,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20847546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Springer, Fabian</creatorcontrib><creatorcontrib>Nguyen, Huu Phuc</creatorcontrib><creatorcontrib>Machann, Jürgen</creatorcontrib><creatorcontrib>Schweizer, Roland</creatorcontrib><creatorcontrib>Ranke, Michael B.</creatorcontrib><creatorcontrib>Binder, Gerhard</creatorcontrib><creatorcontrib>Schick, Fritz</creatorcontrib><creatorcontrib>Ehehalt, Stefan</creatorcontrib><creatorcontrib>DISKUS Study Group</creatorcontrib><creatorcontrib>for the DISKUS Study Group</creatorcontrib><title>Normal-Weight 14-Year-Old Girl with Acanthosis Nigricans and Markedly Increased Hepatic Steatosis: Evidence for the Important Role of Ectopic Fat Deposition in the Pathogenesis of Insulin Resistance in Childhood and Adolescence</title><title>Hormone research in paediatrics</title><addtitle>Horm Res Paediatr</addtitle><description>Background: A major factor in the development of insulin resistance is obesity. While the contribution of intrahepatic lipids to insulin resistance is well established in adults, there are only few reports in childhood and adolescence. Aim: To investigate the correlation between ectopic fat deposition and insulin sensitivity in a normal-weight girl with acanthosis nigricans before and after lifestyle intervention. Methods: Variations in body fat composition and intrahepatic lipids were monitored by means of anthropometric measures and by means of methods based on magnetic resonance imaging and magnetic resonance spectroscopy. Results: We present the case of a normal-weight 14-year-old Caucasian girl with pronounced hepatic steatosis together with acanthosis nigricans, increased waist-circumference and increased visceral fat. During a 7-month period of lifestyle intervention, the girl lost 7.1 kg in weight. Acanthosis nigricans, whole-body insulin sensitivity index (WBISI) and homeostasis model assessment (HOMA) improved significantly (before intervention: WBISI 0.42, HOMA 22.2; after intervention: WBISI 1.35, HOMA 6.9). Even though all lipid compartments were decreased in size, the intrahepatic lipids showed an extraordinarily great reduction. Conclusion: This case presentation of a normal-weight girl with acanthosis nigricans and markedly increased hepatic steatosis provides support for the association between intrahepatic fat deposition and insulin resistance in adolescence.</description><subject>Acanthosis Nigricans - complications</subject><subject>Acanthosis Nigricans - metabolism</subject><subject>Acanthosis Nigricans - pathology</subject><subject>Adipose Tissue</subject><subject>Adolescent</subject><subject>Body Mass Index</subject><subject>Body Weight - physiology</subject><subject>Choristoma - pathology</subject><subject>Diet</subject><subject>Fatty Liver - complications</subject><subject>Fatty Liver - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Life Style</subject><subject>Motor Activity - physiology</subject><subject>Novel Insights from Clinical Practice</subject><subject>Puberty - physiology</subject><subject>Waist-Hip Ratio</subject><issn>1663-2818</issn><issn>1663-2826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkUFv1DAUhCMEolXpgTtCljhUHAJ2YscOt9WybVcqLSogxCny2i8bt4kdbAfU38sfwekue-BkP_ubeSNNlr0k-B0hrH6PMS5JzTF_kh2TqirzQhTV08OdiKPsNIQ7PHOC14Q_z44KLChntDrO_lw7P8g-_w5m20VEaP4DpM9veo0ujO_RbxM7tFDSxs4FE9C12XqTxoCk1eiT9Peg-we0tsqDDKDRJYwyGoW-RJBxlnxAq19Gg1WAWudR7ACth9H5mDzRresBuRatVHRjUp3LiD7CmHTROIuMfeQ_y7R9CxbmBIle2zD16e92fkg-yTpNy870unNOP0Zb6GQd1Lz3RfaslX2A0_15kn07X31dXuZXNxfr5eIqV2VZxpwyKVTVgtB1TetWsUozVm5YtWGsVgTzCrQQ5QYKAIU10YKygvKacknKYiPLk-xs5zt693OCEJvBpAR9Ly24KTS8KgpRUsET-eY_8s5N3qZwDcGCVDXDjCbq7Y5S3oXgoW1GbwbpHxLUzN03h-4T-3rvOG0G0AfyX9MJeLUD7qXfgj8Ae_1f8ae0Ww</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Springer, Fabian</creator><creator>Nguyen, Huu Phuc</creator><creator>Machann, Jürgen</creator><creator>Schweizer, Roland</creator><creator>Ranke, Michael B.</creator><creator>Binder, Gerhard</creator><creator>Schick, Fritz</creator><creator>Ehehalt, Stefan</creator><general>S. 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Nguyen, Huu Phuc ; Machann, Jürgen ; Schweizer, Roland ; Ranke, Michael B. ; Binder, Gerhard ; Schick, Fritz ; Ehehalt, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-45a8c6fe8d9949fc56d553b56b559c1076ed883be2eec0d1d845247947a132ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acanthosis Nigricans - complications</topic><topic>Acanthosis Nigricans - metabolism</topic><topic>Acanthosis Nigricans - pathology</topic><topic>Adipose Tissue</topic><topic>Adolescent</topic><topic>Body Mass Index</topic><topic>Body Weight - physiology</topic><topic>Choristoma - pathology</topic><topic>Diet</topic><topic>Fatty Liver - complications</topic><topic>Fatty Liver - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Life Style</topic><topic>Motor Activity - physiology</topic><topic>Novel Insights from Clinical Practice</topic><topic>Puberty - physiology</topic><topic>Waist-Hip Ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Springer, Fabian</creatorcontrib><creatorcontrib>Nguyen, Huu Phuc</creatorcontrib><creatorcontrib>Machann, Jürgen</creatorcontrib><creatorcontrib>Schweizer, Roland</creatorcontrib><creatorcontrib>Ranke, Michael B.</creatorcontrib><creatorcontrib>Binder, Gerhard</creatorcontrib><creatorcontrib>Schick, Fritz</creatorcontrib><creatorcontrib>Ehehalt, Stefan</creatorcontrib><creatorcontrib>DISKUS Study Group</creatorcontrib><creatorcontrib>for the DISKUS Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone research in paediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Springer, Fabian</au><au>Nguyen, Huu Phuc</au><au>Machann, Jürgen</au><au>Schweizer, Roland</au><au>Ranke, Michael B.</au><au>Binder, Gerhard</au><au>Schick, Fritz</au><au>Ehehalt, Stefan</au><aucorp>DISKUS Study Group</aucorp><aucorp>for the DISKUS Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal-Weight 14-Year-Old Girl with Acanthosis Nigricans and Markedly Increased Hepatic Steatosis: Evidence for the Important Role of Ectopic Fat Deposition in the Pathogenesis of Insulin Resistance in Childhood and Adolescence</atitle><jtitle>Hormone research in paediatrics</jtitle><addtitle>Horm Res Paediatr</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>74</volume><issue>5</issue><spage>376</spage><epage>380</epage><pages>376-380</pages><issn>1663-2818</issn><eissn>1663-2826</eissn><abstract>Background: A major factor in the development of insulin resistance is obesity. While the contribution of intrahepatic lipids to insulin resistance is well established in adults, there are only few reports in childhood and adolescence. Aim: To investigate the correlation between ectopic fat deposition and insulin sensitivity in a normal-weight girl with acanthosis nigricans before and after lifestyle intervention. Methods: Variations in body fat composition and intrahepatic lipids were monitored by means of anthropometric measures and by means of methods based on magnetic resonance imaging and magnetic resonance spectroscopy. Results: We present the case of a normal-weight 14-year-old Caucasian girl with pronounced hepatic steatosis together with acanthosis nigricans, increased waist-circumference and increased visceral fat. During a 7-month period of lifestyle intervention, the girl lost 7.1 kg in weight. Acanthosis nigricans, whole-body insulin sensitivity index (WBISI) and homeostasis model assessment (HOMA) improved significantly (before intervention: WBISI 0.42, HOMA 22.2; after intervention: WBISI 1.35, HOMA 6.9). Even though all lipid compartments were decreased in size, the intrahepatic lipids showed an extraordinarily great reduction. Conclusion: This case presentation of a normal-weight girl with acanthosis nigricans and markedly increased hepatic steatosis provides support for the association between intrahepatic fat deposition and insulin resistance in adolescence.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>20847546</pmid><doi>10.1159/000319707</doi><tpages>5</tpages></addata></record> |
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| ispartof | Hormone research in paediatrics, 2010-01, Vol.74 (5), p.376-380 |
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| subjects | Acanthosis Nigricans - complications Acanthosis Nigricans - metabolism Acanthosis Nigricans - pathology Adipose Tissue Adolescent Body Mass Index Body Weight - physiology Choristoma - pathology Diet Fatty Liver - complications Fatty Liver - pathology Female Humans Insulin resistance Insulin Resistance - physiology Life Style Motor Activity - physiology Novel Insights from Clinical Practice Puberty - physiology Waist-Hip Ratio |
| title | Normal-Weight 14-Year-Old Girl with Acanthosis Nigricans and Markedly Increased Hepatic Steatosis: Evidence for the Important Role of Ectopic Fat Deposition in the Pathogenesis of Insulin Resistance in Childhood and Adolescence |
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