Pre-Operative Intravenous Dexamethasone Prevents Auditory Threshold Shift in a Guinea Pig Model of Cochlear Implantation

Aim: To protect hearing during cochlear implantation with systemic administration of dexamethasone. Methods: Seventeen normal-hearing guinea pigs were randomly allocated to receive an intravenous injection of either normal saline (control), low- (0.2 mg/kg) or high- (2 mg/kg) dose dexamethasone 60 m...

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Veröffentlicht in:	Audiology & neurotology 2011-03, Vol.16 (3), p.137-144
Hauptverfasser:	Connolly, Timothy M., Eastwood, Hayden, Kel, Gordana, Lisnichuk, Halina, Richardson, Rachael, O’Leary, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cochlear Implantation Cochlear implants Delivery. Postpartum. Lactation Dexamethasone - pharmacology Evoked Potentials, Auditory, Brain Stem - physiology Glucocorticoids - pharmacology Guinea Pigs Gynecology. Andrology. Obstetrics Hearing - drug effects Hearing - physiology Hearing protection Medical sciences Original Paper Otorhinolaryngology. Stomatology Pharmacology. Drug treatments Steroids
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