Pre-Operative Intravenous Dexamethasone Prevents Auditory Threshold Shift in a Guinea Pig Model of Cochlear Implantation
Aim: To protect hearing during cochlear implantation with systemic administration of dexamethasone. Methods: Seventeen normal-hearing guinea pigs were randomly allocated to receive an intravenous injection of either normal saline (control), low- (0.2 mg/kg) or high- (2 mg/kg) dose dexamethasone 60 m...
Gespeichert in:
| Veröffentlicht in: | Audiology & neurotology 2011-03, Vol.16 (3), p.137-144 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 144 |
|---|---|
| container_issue | 3 |
| container_start_page | 137 |
| container_title | Audiology & neurotology |
| container_volume | 16 |
| creator | Connolly, Timothy M. Eastwood, Hayden Kel, Gordana Lisnichuk, Halina Richardson, Rachael O’Leary, Stephen |
| description | Aim: To protect hearing during cochlear implantation with systemic administration of dexamethasone. Methods: Seventeen normal-hearing guinea pigs were randomly allocated to receive an intravenous injection of either normal saline (control), low- (0.2 mg/kg) or high- (2 mg/kg) dose dexamethasone 60 min prior to cochlear implantation. Auditory brainstem response (ABR) threshold shifts (2–32 kHz) were estimated between pre- and 4-week-postoperative levels. Results: ABR threshold shifts (8–32 kHz) observed in control and low-dose steroid groups were significantly reduced in the high-dose steroid group. Conclusions: A single, high-dose injection of intravenous dexamethasone protected hearing during cochlear implantation. |
| doi_str_mv | 10.1159/000314757 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_karger_primary_314757</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>876236787</sourcerecordid><originalsourceid>FETCH-LOGICAL-c460t-55cf49add10c53aa65a785328754814afb619fda40a9db41b6076006688f08553</originalsourceid><addsrcrecordid>eNqF0c9rFDEUB_Agiq3Vg3eRIIh4GH3Z_JxjWbUuVFqwnoe3M0kndWayTTKl_e_NuusKXjzlET68H3wJecngA2Oy_ggAnAkt9SNyzMSCVbUGePy7hooDhyPyLKWbwqSU4ik5WoBShmtxTO4vo60uNjZi9neWrqYc8c5OYU70k73H0eYeU5gsLa7850RP587nEB_oVR9t6sPQ0e-9d5n6iSI9m_1kkV76a_otdHagwdFlaPvBYqSrcTPglMuoMD0nTxwOyb7Yvyfkx5fPV8uv1fnF2Wp5el61QkGupGydqLHrGLSSIyqJ2ki-MFoKwwS6tWK161AA1t1asLUCrWB7nnFgpOQn5N2u7yaG29mm3Iw-tXYoi9hyZWO0WnCljf6_lLWoGde8yDf_yJswx6mc0Rhlyn4GtoPf71AbQ0rRumYT_YjxoWHQbGNrDrEV-3rfcF6PtjvIPzkV8HYPMLU4uIhT69NfJ0rInG03e7VzPzFe23gA-zm_AJxrpuo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>868785805</pqid></control><display><type>article</type><title>Pre-Operative Intravenous Dexamethasone Prevents Auditory Threshold Shift in a Guinea Pig Model of Cochlear Implantation</title><source>MEDLINE</source><source>Karger Journals Complete</source><source>Alma/SFX Local Collection</source><creator>Connolly, Timothy M. ; Eastwood, Hayden ; Kel, Gordana ; Lisnichuk, Halina ; Richardson, Rachael ; O’Leary, Stephen</creator><creatorcontrib>Connolly, Timothy M. ; Eastwood, Hayden ; Kel, Gordana ; Lisnichuk, Halina ; Richardson, Rachael ; O’Leary, Stephen</creatorcontrib><description>Aim: To protect hearing during cochlear implantation with systemic administration of dexamethasone. Methods: Seventeen normal-hearing guinea pigs were randomly allocated to receive an intravenous injection of either normal saline (control), low- (0.2 mg/kg) or high- (2 mg/kg) dose dexamethasone 60 min prior to cochlear implantation. Auditory brainstem response (ABR) threshold shifts (2–32 kHz) were estimated between pre- and 4-week-postoperative levels. Results: ABR threshold shifts (8–32 kHz) observed in control and low-dose steroid groups were significantly reduced in the high-dose steroid group. Conclusions: A single, high-dose injection of intravenous dexamethasone protected hearing during cochlear implantation.</description><identifier>ISSN: 1420-3030</identifier><identifier>EISSN: 1421-9700</identifier><identifier>DOI: 10.1159/000314757</identifier><identifier>PMID: 20668374</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Animals ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Cochlear Implantation ; Cochlear implants ; Delivery. Postpartum. Lactation ; Dexamethasone - pharmacology ; Evoked Potentials, Auditory, Brain Stem - physiology ; Glucocorticoids - pharmacology ; Guinea Pigs ; Gynecology. Andrology. Obstetrics ; Hearing - drug effects ; Hearing - physiology ; Hearing protection ; Medical sciences ; Original Paper ; Otorhinolaryngology. Stomatology ; Pharmacology. Drug treatments ; Steroids</subject><ispartof>Audiology & neurotology, 2011-03, Vol.16 (3), p.137-144</ispartof><rights>2010 S. Karger AG, Basel</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-55cf49add10c53aa65a785328754814afb619fda40a9db41b6076006688f08553</citedby><cites>FETCH-LOGICAL-c460t-55cf49add10c53aa65a785328754814afb619fda40a9db41b6076006688f08553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24030313$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20668374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Connolly, Timothy M.</creatorcontrib><creatorcontrib>Eastwood, Hayden</creatorcontrib><creatorcontrib>Kel, Gordana</creatorcontrib><creatorcontrib>Lisnichuk, Halina</creatorcontrib><creatorcontrib>Richardson, Rachael</creatorcontrib><creatorcontrib>O’Leary, Stephen</creatorcontrib><title>Pre-Operative Intravenous Dexamethasone Prevents Auditory Threshold Shift in a Guinea Pig Model of Cochlear Implantation</title><title>Audiology & neurotology</title><addtitle>Audiol Neurotol</addtitle><description>Aim: To protect hearing during cochlear implantation with systemic administration of dexamethasone. Methods: Seventeen normal-hearing guinea pigs were randomly allocated to receive an intravenous injection of either normal saline (control), low- (0.2 mg/kg) or high- (2 mg/kg) dose dexamethasone 60 min prior to cochlear implantation. Auditory brainstem response (ABR) threshold shifts (2–32 kHz) were estimated between pre- and 4-week-postoperative levels. Results: ABR threshold shifts (8–32 kHz) observed in control and low-dose steroid groups were significantly reduced in the high-dose steroid group. Conclusions: A single, high-dose injection of intravenous dexamethasone protected hearing during cochlear implantation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Cochlear Implantation</subject><subject>Cochlear implants</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Dexamethasone - pharmacology</subject><subject>Evoked Potentials, Auditory, Brain Stem - physiology</subject><subject>Glucocorticoids - pharmacology</subject><subject>Guinea Pigs</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hearing - drug effects</subject><subject>Hearing - physiology</subject><subject>Hearing protection</subject><subject>Medical sciences</subject><subject>Original Paper</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pharmacology. Drug treatments</subject><subject>Steroids</subject><issn>1420-3030</issn><issn>1421-9700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0c9rFDEUB_Agiq3Vg3eRIIh4GH3Z_JxjWbUuVFqwnoe3M0kndWayTTKl_e_NuusKXjzlET68H3wJecngA2Oy_ggAnAkt9SNyzMSCVbUGePy7hooDhyPyLKWbwqSU4ik5WoBShmtxTO4vo60uNjZi9neWrqYc8c5OYU70k73H0eYeU5gsLa7850RP587nEB_oVR9t6sPQ0e-9d5n6iSI9m_1kkV76a_otdHagwdFlaPvBYqSrcTPglMuoMD0nTxwOyb7Yvyfkx5fPV8uv1fnF2Wp5el61QkGupGydqLHrGLSSIyqJ2ki-MFoKwwS6tWK161AA1t1asLUCrWB7nnFgpOQn5N2u7yaG29mm3Iw-tXYoi9hyZWO0WnCljf6_lLWoGde8yDf_yJswx6mc0Rhlyn4GtoPf71AbQ0rRumYT_YjxoWHQbGNrDrEV-3rfcF6PtjvIPzkV8HYPMLU4uIhT69NfJ0rInG03e7VzPzFe23gA-zm_AJxrpuo</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Connolly, Timothy M.</creator><creator>Eastwood, Hayden</creator><creator>Kel, Gordana</creator><creator>Lisnichuk, Halina</creator><creator>Richardson, Rachael</creator><creator>O’Leary, Stephen</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201103</creationdate><title>Pre-Operative Intravenous Dexamethasone Prevents Auditory Threshold Shift in a Guinea Pig Model of Cochlear Implantation</title><author>Connolly, Timothy M. ; Eastwood, Hayden ; Kel, Gordana ; Lisnichuk, Halina ; Richardson, Rachael ; O’Leary, Stephen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-55cf49add10c53aa65a785328754814afb619fda40a9db41b6076006688f08553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Cochlear Implantation</topic><topic>Cochlear implants</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Dexamethasone - pharmacology</topic><topic>Evoked Potentials, Auditory, Brain Stem - physiology</topic><topic>Glucocorticoids - pharmacology</topic><topic>Guinea Pigs</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hearing - drug effects</topic><topic>Hearing - physiology</topic><topic>Hearing protection</topic><topic>Medical sciences</topic><topic>Original Paper</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pharmacology. Drug treatments</topic><topic>Steroids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Connolly, Timothy M.</creatorcontrib><creatorcontrib>Eastwood, Hayden</creatorcontrib><creatorcontrib>Kel, Gordana</creatorcontrib><creatorcontrib>Lisnichuk, Halina</creatorcontrib><creatorcontrib>Richardson, Rachael</creatorcontrib><creatorcontrib>O’Leary, Stephen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Audiology & neurotology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Connolly, Timothy M.</au><au>Eastwood, Hayden</au><au>Kel, Gordana</au><au>Lisnichuk, Halina</au><au>Richardson, Rachael</au><au>O’Leary, Stephen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pre-Operative Intravenous Dexamethasone Prevents Auditory Threshold Shift in a Guinea Pig Model of Cochlear Implantation</atitle><jtitle>Audiology & neurotology</jtitle><addtitle>Audiol Neurotol</addtitle><date>2011-03</date><risdate>2011</risdate><volume>16</volume><issue>3</issue><spage>137</spage><epage>144</epage><pages>137-144</pages><issn>1420-3030</issn><eissn>1421-9700</eissn><abstract>Aim: To protect hearing during cochlear implantation with systemic administration of dexamethasone. Methods: Seventeen normal-hearing guinea pigs were randomly allocated to receive an intravenous injection of either normal saline (control), low- (0.2 mg/kg) or high- (2 mg/kg) dose dexamethasone 60 min prior to cochlear implantation. Auditory brainstem response (ABR) threshold shifts (2–32 kHz) were estimated between pre- and 4-week-postoperative levels. Results: ABR threshold shifts (8–32 kHz) observed in control and low-dose steroid groups were significantly reduced in the high-dose steroid group. Conclusions: A single, high-dose injection of intravenous dexamethasone protected hearing during cochlear implantation.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>20668374</pmid><doi>10.1159/000314757</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1420-3030 |
| ispartof | Audiology & neurotology, 2011-03, Vol.16 (3), p.137-144 |
| issn | 1420-3030 1421-9700 |
| language | eng |
| recordid | cdi_karger_primary_314757 |
| source | MEDLINE; Karger Journals Complete; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cochlear Implantation Cochlear implants Delivery. Postpartum. Lactation Dexamethasone - pharmacology Evoked Potentials, Auditory, Brain Stem - physiology Glucocorticoids - pharmacology Guinea Pigs Gynecology. Andrology. Obstetrics Hearing - drug effects Hearing - physiology Hearing protection Medical sciences Original Paper Otorhinolaryngology. Stomatology Pharmacology. Drug treatments Steroids |
| title | Pre-Operative Intravenous Dexamethasone Prevents Auditory Threshold Shift in a Guinea Pig Model of Cochlear Implantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T20%3A01%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_karge&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pre-Operative%20Intravenous%20Dexamethasone%20Prevents%20Auditory%20Threshold%20Shift%20in%20a%20Guinea%20Pig%20Model%20of%20Cochlear%20Implantation&rft.jtitle=Audiology%20&%20neurotology&rft.au=Connolly,%20Timothy%20M.&rft.date=2011-03&rft.volume=16&rft.issue=3&rft.spage=137&rft.epage=144&rft.pages=137-144&rft.issn=1420-3030&rft.eissn=1421-9700&rft_id=info:doi/10.1159/000314757&rft_dat=%3Cproquest_karge%3E876236787%3C/proquest_karge%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=868785805&rft_id=info:pmid/20668374&rfr_iscdi=true |