Levels of Corticosteroid-Binding Globulin mRNA in Human Ovarian Cancers
To understand the role of corticosteroid-binding globulin (CBG) in the intracellular steroidal actions in human ovarian cancers, the level of CBG mRNA expression was evaluated in normal ovarian tissues and in ovarian cancers using competitive reverse transcription-polymerase chain reaction-Southern...
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| Veröffentlicht in: | Tumor biology 1999-09, Vol.20 (5), p.263-269 |
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| creator | Misao, Ryou Iwagaki, Shigenori Sun, Wen-Shu Fujimoto, Jiro Tamaya, Teruhiko |
| description | To understand the role of corticosteroid-binding globulin (CBG) in the intracellular steroidal actions in human ovarian cancers, the level of CBG mRNA expression was evaluated in normal ovarian tissues and in ovarian cancers using competitive reverse transcription-polymerase chain reaction-Southern blot analysis. The expression of CBG mRNA was detected in all normal ovaries and ovarian cancers analyzed. There were no significant differences in the mean CBG mRNA levels between normal ovaries and ovarian cancers. The expression in normal ovaries was significantly higher (p < 0.01) in the premenopause than in the postmenopause. A high expression of CBG mRNA was observed in 11 out of 29 cases (38%) of ovarian cancer in comparison with normal ovaries. There was no difference in the expression among the histological classifications or clinical stages of ovarian cancers. These data suggest that human normal ovaries and ovarian cancers might synthesize CBG intracellularly, ovarian cancers might conserve a progesterone-associated property via CBG, and the regulation of intracelluar CBG expression might be changed in some cancers. |
| doi_str_mv | 10.1159/000030073 |
| format | Article |
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The expression of CBG mRNA was detected in all normal ovaries and ovarian cancers analyzed. There were no significant differences in the mean CBG mRNA levels between normal ovaries and ovarian cancers. The expression in normal ovaries was significantly higher (p < 0.01) in the premenopause than in the postmenopause. A high expression of CBG mRNA was observed in 11 out of 29 cases (38%) of ovarian cancer in comparison with normal ovaries. There was no difference in the expression among the histological classifications or clinical stages of ovarian cancers. These data suggest that human normal ovaries and ovarian cancers might synthesize CBG intracellularly, ovarian cancers might conserve a progesterone-associated property via CBG, and the regulation of intracelluar CBG expression might be changed in some cancers.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1159/000030073</identifier><identifier>PMID: 10436419</identifier><identifier>CODEN: OBIMD4</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blotting, Southern ; Carcinoma - genetics ; Carcinoma - metabolism ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Middle Aged ; Original Paper ; Ovarian Neoplasms - genetics ; Ovarian Neoplasms - metabolism ; Postmenopause - genetics ; Premenopause - genetics ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Transcortin - genetics ; Transcortin - metabolism ; Tumors</subject><ispartof>Tumor biology, 1999-09, Vol.20 (5), p.263-269</ispartof><rights>1999 S. Karger AG, Basel</rights><rights>1999 INIST-CNRS</rights><rights>Copyright (c) 1999 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-6297f0f7db4ca789b4c77d9201c18c095c5e3bbc57d5be2c954ab59fdc2f23e43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2422,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1886626$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10436419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Misao, Ryou</creatorcontrib><creatorcontrib>Iwagaki, Shigenori</creatorcontrib><creatorcontrib>Sun, Wen-Shu</creatorcontrib><creatorcontrib>Fujimoto, Jiro</creatorcontrib><creatorcontrib>Tamaya, Teruhiko</creatorcontrib><title>Levels of Corticosteroid-Binding Globulin mRNA in Human Ovarian Cancers</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><description>To understand the role of corticosteroid-binding globulin (CBG) in the intracellular steroidal actions in human ovarian cancers, the level of CBG mRNA expression was evaluated in normal ovarian tissues and in ovarian cancers using competitive reverse transcription-polymerase chain reaction-Southern blot analysis. The expression of CBG mRNA was detected in all normal ovaries and ovarian cancers analyzed. There were no significant differences in the mean CBG mRNA levels between normal ovaries and ovarian cancers. The expression in normal ovaries was significantly higher (p < 0.01) in the premenopause than in the postmenopause. A high expression of CBG mRNA was observed in 11 out of 29 cases (38%) of ovarian cancer in comparison with normal ovaries. There was no difference in the expression among the histological classifications or clinical stages of ovarian cancers. These data suggest that human normal ovaries and ovarian cancers might synthesize CBG intracellularly, ovarian cancers might conserve a progesterone-associated property via CBG, and the regulation of intracelluar CBG expression might be changed in some cancers.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blotting, Southern</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - metabolism</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Postmenopause - genetics</subject><subject>Premenopause - genetics</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - metabolism</subject><subject>Transcortin - genetics</subject><subject>Transcortin - metabolism</subject><subject>Tumors</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0M1LwzAYBvAgipvTg2dByhDBQzUfbdMct6JzMBzIPJc0TUZm28xkHfjfG-2cIubyBN4fb8IDwDmCtwjF7A76QyCk5AD0UYRJCEkKD_0dIhhGOCU9cOLcCkKPWXIMeghGJIkQ64PJTG5l5QKjgszYjRbGbaQ1ugzHuil1swwmlSnaSjdB_fw0Cnw-tjVvgvmWW-0z442Q1p2CI8UrJ892OQAvD_eL7DGczSfTbDQLBUmjTZhgRhVUtCwiwWnKfFBaMgyRQKmALBaxJEUhYlrGhcSCxREvYqZKgRUmMiIDcN3tXVvz1kq3yWvthKwq3kjTujxhLCbI1zEAwz9wZVrb-L_lGOOEUt-NRzcdEtY4Z6XK11bX3L7nCOaf1eb7ar293C1si1qWv2TXpQdXO8Cd4JWyvhntflyaJglOPLvo2Cu3S2n38-9Xhv9OF-PpF8jXpSIfBh-Ssw</recordid><startdate>19990901</startdate><enddate>19990901</enddate><creator>Misao, Ryou</creator><creator>Iwagaki, Shigenori</creator><creator>Sun, Wen-Shu</creator><creator>Fujimoto, Jiro</creator><creator>Tamaya, Teruhiko</creator><general>Karger</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19990901</creationdate><title>Levels of Corticosteroid-Binding Globulin mRNA in Human Ovarian Cancers</title><author>Misao, Ryou ; Iwagaki, Shigenori ; Sun, Wen-Shu ; Fujimoto, Jiro ; Tamaya, Teruhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-6297f0f7db4ca789b4c77d9201c18c095c5e3bbc57d5be2c954ab59fdc2f23e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blotting, Southern</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - metabolism</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. 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Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Postmenopause - genetics</topic><topic>Premenopause - genetics</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - metabolism</topic><topic>Transcortin - genetics</topic><topic>Transcortin - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Misao, Ryou</creatorcontrib><creatorcontrib>Iwagaki, Shigenori</creatorcontrib><creatorcontrib>Sun, Wen-Shu</creatorcontrib><creatorcontrib>Fujimoto, Jiro</creatorcontrib><creatorcontrib>Tamaya, Teruhiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Misao, Ryou</au><au>Iwagaki, Shigenori</au><au>Sun, Wen-Shu</au><au>Fujimoto, Jiro</au><au>Tamaya, Teruhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Levels of Corticosteroid-Binding Globulin mRNA in Human Ovarian Cancers</atitle><jtitle>Tumor biology</jtitle><addtitle>Tumor Biol</addtitle><date>1999-09-01</date><risdate>1999</risdate><volume>20</volume><issue>5</issue><spage>263</spage><epage>269</epage><pages>263-269</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><coden>OBIMD4</coden><abstract>To understand the role of corticosteroid-binding globulin (CBG) in the intracellular steroidal actions in human ovarian cancers, the level of CBG mRNA expression was evaluated in normal ovarian tissues and in ovarian cancers using competitive reverse transcription-polymerase chain reaction-Southern blot analysis. 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| ispartof | Tumor biology, 1999-09, Vol.20 (5), p.263-269 |
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| source | Karger Journals; MEDLINE |
| subjects | Adult Aged Biological and medical sciences Blotting, Southern Carcinoma - genetics Carcinoma - metabolism Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Original Paper Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Postmenopause - genetics Premenopause - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Transcortin - genetics Transcortin - metabolism Tumors |
| title | Levels of Corticosteroid-Binding Globulin mRNA in Human Ovarian Cancers |
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