Characteristics of Plasmid-Mediated Quinolone Resistance Genes in Extended-Spectrum Cephalosporin-Resistant Isolates of Klebsiella pneumoniae and Escherichia coli in Korea
Background: Quinolone resistance is frequently associated with extended-spectrum cephalosporin resistance in Enterobacteriaceae. Methods: The characteristics of plasmid-mediated quinolone resistance (PMQR) genes [qnr genes, aac(6′)-Ib-cr and qepA] in clinical isolates of Klebsiella pneumoniae and Es...
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| Veröffentlicht in: | Chemotherapy (Basel) 2010-01, Vol.56 (1), p.46-53 |
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| description | Background: Quinolone resistance is frequently associated with extended-spectrum cephalosporin resistance in Enterobacteriaceae. Methods: The characteristics of plasmid-mediated quinolone resistance (PMQR) genes [qnr genes, aac(6′)-Ib-cr and qepA] in clinical isolates of Klebsiella pneumoniae and Escherichia coli resistant to extended-spectrum cephalosporin were studied. Results: 5 and 4 of 95 E. coli isolates but 46 (86/187) and 6% (12/187) of K. pneumoniae had qnr and aac(6′)-Ib-cr, respectively, and 8 K. pneumoniae contained both genes.qepA was not identified. qnrB, especially qnrB4, was the predominant qnr subtype in K. pneumoniae [94 (88 qnrB of 94 qnr) and 88% (77 qnrB4 of 88 qnrB), respectively], and presence of qnrB4 was closely related with DHA-1 β-lactamase (99%). However, K. pneumoniae isolates with qnrB4 and bla DHA-1 were clonally diverse. β-Lactamases produced by PMQR-containing isolates were variable: CMY-1, CTX-M-14, CTX-M-15, DHA-1, OXA type, SHV-2a, and SHV-12. Conclusion: PMQR genes are widely distributed among clinical isolates of K. pneumoniae, and qnrB4 associated with bla DHA-1 was the most common PMQR gene in Korea. |
| doi_str_mv | 10.1159/000290972 |
| format | Article |
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Methods: The characteristics of plasmid-mediated quinolone resistance (PMQR) genes [qnr genes, aac(6′)-Ib-cr and qepA] in clinical isolates of Klebsiella pneumoniae and Escherichia coli resistant to extended-spectrum cephalosporin were studied. Results: 5 and 4 of 95 E. coli isolates but 46 (86/187) and 6% (12/187) of K. pneumoniae had qnr and aac(6′)-Ib-cr, respectively, and 8 K. pneumoniae contained both genes.qepA was not identified. qnrB, especially qnrB4, was the predominant qnr subtype in K. pneumoniae [94 (88 qnrB of 94 qnr) and 88% (77 qnrB4 of 88 qnrB), respectively], and presence of qnrB4 was closely related with DHA-1 β-lactamase (99%). However, K. pneumoniae isolates with qnrB4 and bla DHA-1 were clonally diverse. β-Lactamases produced by PMQR-containing isolates were variable: CMY-1, CTX-M-14, CTX-M-15, DHA-1, OXA type, SHV-2a, and SHV-12. Conclusion: PMQR genes are widely distributed among clinical isolates of K. pneumoniae, and qnrB4 associated with bla DHA-1 was the most common PMQR gene in Korea.</description><identifier>ISSN: 0009-3157</identifier><identifier>EISSN: 1421-9794</identifier><identifier>DOI: 10.1159/000290972</identifier><identifier>PMID: 20203489</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Anti-Bacterial Agents - pharmacology ; beta-Lactamases - metabolism ; Cephalosporins - pharmacology ; Cluster Analysis ; Drug resistance ; Drug Resistance, Multiple, Bacterial - genetics ; E coli ; Enterobacteriaceae ; Escherichia coli ; Escherichia coli - drug effects ; Escherichia coli - genetics ; Escherichia coli - isolation & purification ; Genes ; Klebsiella pneumoniae ; Klebsiella pneumoniae - drug effects ; Klebsiella pneumoniae - genetics ; Klebsiella pneumoniae - isolation & purification ; Microbiology ; Plasmids ; Pneumonia ; Quinolones - pharmacology ; Republic of Korea</subject><ispartof>Chemotherapy (Basel), 2010-01, Vol.56 (1), p.46-53</ispartof><rights>2010 S. Karger AG, Basel</rights><rights>Copyright 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2010 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-5cebcd103d39cfc4afc43e11f99c5eeda54910f112d2e71779b7983a7d3725023</citedby><cites>FETCH-LOGICAL-c430t-5cebcd103d39cfc4afc43e11f99c5eeda54910f112d2e71779b7983a7d3725023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20203489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seo, Mi-Ran</creatorcontrib><creatorcontrib>Park, Yoon Soo</creatorcontrib><creatorcontrib>Pai, Hyunjoo</creatorcontrib><title>Characteristics of Plasmid-Mediated Quinolone Resistance Genes in Extended-Spectrum Cephalosporin-Resistant Isolates of Klebsiella pneumoniae and Escherichia coli in Korea</title><title>Chemotherapy (Basel)</title><addtitle>Chemotherapy</addtitle><description>Background: Quinolone resistance is frequently associated with extended-spectrum cephalosporin resistance in Enterobacteriaceae. Methods: The characteristics of plasmid-mediated quinolone resistance (PMQR) genes [qnr genes, aac(6′)-Ib-cr and qepA] in clinical isolates of Klebsiella pneumoniae and Escherichia coli resistant to extended-spectrum cephalosporin were studied. Results: 5 and 4 of 95 E. coli isolates but 46 (86/187) and 6% (12/187) of K. pneumoniae had qnr and aac(6′)-Ib-cr, respectively, and 8 K. pneumoniae contained both genes.qepA was not identified. qnrB, especially qnrB4, was the predominant qnr subtype in K. pneumoniae [94 (88 qnrB of 94 qnr) and 88% (77 qnrB4 of 88 qnrB), respectively], and presence of qnrB4 was closely related with DHA-1 β-lactamase (99%). However, K. pneumoniae isolates with qnrB4 and bla DHA-1 were clonally diverse. β-Lactamases produced by PMQR-containing isolates were variable: CMY-1, CTX-M-14, CTX-M-15, DHA-1, OXA type, SHV-2a, and SHV-12. Conclusion: PMQR genes are widely distributed among clinical isolates of K. pneumoniae, and qnrB4 associated with bla DHA-1 was the most common PMQR gene in Korea.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>beta-Lactamases - metabolism</subject><subject>Cephalosporins - pharmacology</subject><subject>Cluster Analysis</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>E coli</subject><subject>Enterobacteriaceae</subject><subject>Escherichia coli</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - genetics</subject><subject>Escherichia coli - isolation & purification</subject><subject>Genes</subject><subject>Klebsiella pneumoniae</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Klebsiella pneumoniae - genetics</subject><subject>Klebsiella pneumoniae - isolation & purification</subject><subject>Microbiology</subject><subject>Plasmids</subject><subject>Pneumonia</subject><subject>Quinolones - pharmacology</subject><subject>Republic of Korea</subject><issn>0009-3157</issn><issn>1421-9794</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0c1rFDEUAPAgit1WD95FghfxMJrPyeRYlrWWVvw-D9nkjZuaScZkBuzf5D9p1m0rePEQQh6_9xEeQk8oeUWp1K8JIUwTrdg9tKKC0UYrLe6jVY3rhlOpjtBxKVf1yVtOH6IjRhjhotMr9Gu9M9nYGbIvs7cFpwF_CKaM3jXvwHkzg8MfFx9TSBHwJyjVmWgBn0GEgn3Em58zRAeu-TyBnfMy4jVMOxNSmVL2sbnNmfF5SaEW_NPkIsC2eAjB4CnCMqboDWATHd4Uu6vj2J032Kbg9z0uUgbzCD0YTCjw-OY-QV_fbL6s3zaX78_O16eXjRWczI20sLWOEu64toMVph4OlA5aWwngjBSakoFS5hgoqpTeKt1xoxxXTBLGT9CLQ90ppx8LlLkffbH7USOkpfRKCNm1XUf-LzlvhWjJXj7_R16lJcf6jb4Vkikhparo5QHZnErJMPRT9qPJ1z0l_X7T_d2mq312U3DZjuDu5O1qK3h6AN9N_gb5Lzjk_wZ1ZK6y</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Seo, Mi-Ran</creator><creator>Park, Yoon Soo</creator><creator>Pai, Hyunjoo</creator><general>S. 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Park, Yoon Soo ; Pai, Hyunjoo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-5cebcd103d39cfc4afc43e11f99c5eeda54910f112d2e71779b7983a7d3725023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>beta-Lactamases - metabolism</topic><topic>Cephalosporins - pharmacology</topic><topic>Cluster Analysis</topic><topic>Drug resistance</topic><topic>Drug Resistance, Multiple, Bacterial - genetics</topic><topic>E coli</topic><topic>Enterobacteriaceae</topic><topic>Escherichia coli</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - genetics</topic><topic>Escherichia coli - isolation & purification</topic><topic>Genes</topic><topic>Klebsiella pneumoniae</topic><topic>Klebsiella pneumoniae - drug effects</topic><topic>Klebsiella pneumoniae - genetics</topic><topic>Klebsiella pneumoniae - isolation & purification</topic><topic>Microbiology</topic><topic>Plasmids</topic><topic>Pneumonia</topic><topic>Quinolones - pharmacology</topic><topic>Republic of Korea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seo, Mi-Ran</creatorcontrib><creatorcontrib>Park, Yoon Soo</creatorcontrib><creatorcontrib>Pai, Hyunjoo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Chemotherapy (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seo, Mi-Ran</au><au>Park, Yoon Soo</au><au>Pai, Hyunjoo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics of Plasmid-Mediated Quinolone Resistance Genes in Extended-Spectrum Cephalosporin-Resistant Isolates of Klebsiella pneumoniae and Escherichia coli in Korea</atitle><jtitle>Chemotherapy (Basel)</jtitle><addtitle>Chemotherapy</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>56</volume><issue>1</issue><spage>46</spage><epage>53</epage><pages>46-53</pages><issn>0009-3157</issn><eissn>1421-9794</eissn><abstract>Background: Quinolone resistance is frequently associated with extended-spectrum cephalosporin resistance in Enterobacteriaceae. Methods: The characteristics of plasmid-mediated quinolone resistance (PMQR) genes [qnr genes, aac(6′)-Ib-cr and qepA] in clinical isolates of Klebsiella pneumoniae and Escherichia coli resistant to extended-spectrum cephalosporin were studied. Results: 5 and 4 of 95 E. coli isolates but 46 (86/187) and 6% (12/187) of K. pneumoniae had qnr and aac(6′)-Ib-cr, respectively, and 8 K. pneumoniae contained both genes.qepA was not identified. qnrB, especially qnrB4, was the predominant qnr subtype in K. pneumoniae [94 (88 qnrB of 94 qnr) and 88% (77 qnrB4 of 88 qnrB), respectively], and presence of qnrB4 was closely related with DHA-1 β-lactamase (99%). However, K. pneumoniae isolates with qnrB4 and bla DHA-1 were clonally diverse. β-Lactamases produced by PMQR-containing isolates were variable: CMY-1, CTX-M-14, CTX-M-15, DHA-1, OXA type, SHV-2a, and SHV-12. Conclusion: PMQR genes are widely distributed among clinical isolates of K. pneumoniae, and qnrB4 associated with bla DHA-1 was the most common PMQR gene in Korea.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>20203489</pmid><doi>10.1159/000290972</doi><tpages>8</tpages></addata></record> |
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| subjects | Anti-Bacterial Agents - pharmacology beta-Lactamases - metabolism Cephalosporins - pharmacology Cluster Analysis Drug resistance Drug Resistance, Multiple, Bacterial - genetics E coli Enterobacteriaceae Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - isolation & purification Genes Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Microbiology Plasmids Pneumonia Quinolones - pharmacology Republic of Korea |
| title | Characteristics of Plasmid-Mediated Quinolone Resistance Genes in Extended-Spectrum Cephalosporin-Resistant Isolates of Klebsiella pneumoniae and Escherichia coli in Korea |
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