(±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Clinical Studies
(±)3,4-Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) is a brain serotonergic neurotoxin in experimental animals, including nonhuman primates. It is also an increasingly popular recreational drug of abuse, and doses of MDMA that are used recreationally overlap with those that produce serotonin (5-H...
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| Veröffentlicht in: | Neuropsychobiology 2000-01, Vol.42 (1), p.11-16 |
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| creator | McCann, Una D. Eligulashvili, Victoria Ricaurte, George A. |
| description | (±)3,4-Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) is a brain serotonergic neurotoxin in experimental animals, including nonhuman primates. It is also an increasingly popular recreational drug of abuse, and doses of MDMA that are used recreationally overlap with those that produce serotonin (5-HT) neurotoxicity in animals. Studies in human MDMA users probing for evidence of brain serotonergic neurotoxicity indicate that some MDMA users may incur MDMA-related 5-HT neural injury and, possibly, functional sequelae. In particular, MDMA users have selective decrements in cerebrospinal fluid 5-hydroxyindoleacetic acid and brain 5-HT transporters, similar to nonhuman primates with documented MDMA-induced neurotoxicity. Functional abnormalities seen in MDMA users that may be related to 5- HT injury include cognitive deficits, altered sleep architecture, altered neuroendocrine function, altered behavioral responses to 5-HT selective drugs, and increased impulsivity. Additional studies in animals, as well as longitudinal and epidemiological studies in MDMA users, are required to confirm and extend the present data, and to determine whether MDMA users are at increased risk for developing neuropsychiatric illness as they age. |
| doi_str_mv | 10.1159/000026665 |
| format | Article |
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Additional studies in animals, as well as longitudinal and epidemiological studies in MDMA users, are required to confirm and extend the present data, and to determine whether MDMA users are at increased risk for developing neuropsychiatric illness as they age.</description><identifier>ISSN: 0302-282X</identifier><identifier>ISBN: 9783805571104</identifier><identifier>ISBN: 3805571100</identifier><identifier>EISSN: 1423-0224</identifier><identifier>EISBN: 9783318006094</identifier><identifier>EISBN: 3318006092</identifier><identifier>DOI: 10.1159/000026665</identifier><identifier>PMID: 10867551</identifier><identifier>CODEN: NPBYAL</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Hallucinogens - toxicity ; Humans ; N-Methyl-3,4-methylenedioxyamphetamine - toxicity ; Neurotoxicity Syndromes - metabolism ; Neurotoxicity Syndromes - pathology ; Neurotoxicity Syndromes - psychology ; Neurotransmission and behavior ; Primates ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Serotonin - metabolism ; Serotonin - physiology ; Serotonin Agents - toxicity</subject><ispartof>Neuropsychobiology, 2000-01, Vol.42 (1), p.11-16</ispartof><rights>2000 S. Karger AG, Basel</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 S. Karger AG, Basel</rights><rights>Copyright S. Karger AG Jun 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-527ff49df023d7b268b2eca1e87aaba8a297735f16ee70a66a3269d4a2fc047d3</citedby><cites>FETCH-LOGICAL-c415t-527ff49df023d7b268b2eca1e87aaba8a297735f16ee70a66a3269d4a2fc047d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1527330$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10867551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McCann, Una D.</creatorcontrib><creatorcontrib>Eligulashvili, Victoria</creatorcontrib><creatorcontrib>Ricaurte, George A.</creatorcontrib><title>(±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Clinical Studies</title><title>Neuropsychobiology</title><addtitle>Neuropsychobiology</addtitle><description>(±)3,4-Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) is a brain serotonergic neurotoxin in experimental animals, including nonhuman primates. It is also an increasingly popular recreational drug of abuse, and doses of MDMA that are used recreationally overlap with those that produce serotonin (5-HT) neurotoxicity in animals. Studies in human MDMA users probing for evidence of brain serotonergic neurotoxicity indicate that some MDMA users may incur MDMA-related 5-HT neural injury and, possibly, functional sequelae. In particular, MDMA users have selective decrements in cerebrospinal fluid 5-hydroxyindoleacetic acid and brain 5-HT transporters, similar to nonhuman primates with documented MDMA-induced neurotoxicity. Functional abnormalities seen in MDMA users that may be related to 5- HT injury include cognitive deficits, altered sleep architecture, altered neuroendocrine function, altered behavioral responses to 5-HT selective drugs, and increased impulsivity. Additional studies in animals, as well as longitudinal and epidemiological studies in MDMA users, are required to confirm and extend the present data, and to determine whether MDMA users are at increased risk for developing neuropsychiatric illness as they age.</description><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hallucinogens - toxicity</subject><subject>Humans</subject><subject>N-Methyl-3,4-methylenedioxyamphetamine - toxicity</subject><subject>Neurotoxicity Syndromes - metabolism</subject><subject>Neurotoxicity Syndromes - pathology</subject><subject>Neurotoxicity Syndromes - psychology</subject><subject>Neurotransmission and behavior</subject><subject>Primates</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Serotonin - metabolism</subject><subject>Serotonin - physiology</subject><subject>Serotonin Agents - toxicity</subject><issn>0302-282X</issn><issn>1423-0224</issn><isbn>9783805571104</isbn><isbn>3805571100</isbn><isbn>9783318006094</isbn><isbn>3318006092</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkdtqFTEUhuMJu6298FqQQUS6wdGVwyQz3pVN1UKtwlbwbshO1rRp57BNZqBz18eoj-Er-Ch9ElNn04qYm2Txf6z151-EPKHwmtKseAPxMClldofsFCrnnOYAEgpxl8yoYDwFxsS9ScshyxSlIO6TGXBgKcvZty3yKIRTACoKVTwkWxRyqbKMzsjx7q-fc_5KpB-xPxlrbNG67nxsYqWb9Qn2unEtJrtXF5f7JvQ6jFcXP-bpQWsHgzZZou_6rnVtcoTD9fPcGdePb5NF7VpndJ0s-8E6DI_Jg0rXAXc29zb5-m7_y-JDevjp_cFi7zA1gmZ9mjFVVaKwFTBu1YrJfMXQaIq50nqlc80KpXhWUYmoQEupOZOFFZpVBoSyfJu8nPquffd9wNCXjQsG61q32A2hZFDERHMawef_gKfd4NvorWScC0ajnwjNJ8j4LgSPVbn2rtF-LCmU16spb1YT2WebhsOqQfsXOWUdgRcbQIeYTOV1a1y45eLfOYdbY2faH6O_0Y8-L_8MKte2itDT_0KTld-Vw6dE</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>McCann, Una D.</creator><creator>Eligulashvili, Victoria</creator><creator>Ricaurte, George A.</creator><general>Karger</general><general>S. 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Psychology</topic><topic>Hallucinogens - toxicity</topic><topic>Humans</topic><topic>N-Methyl-3,4-methylenedioxyamphetamine - toxicity</topic><topic>Neurotoxicity Syndromes - metabolism</topic><topic>Neurotoxicity Syndromes - pathology</topic><topic>Neurotoxicity Syndromes - psychology</topic><topic>Neurotransmission and behavior</topic><topic>Primates</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Serotonin - metabolism</topic><topic>Serotonin - physiology</topic><topic>Serotonin Agents - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCann, Una D.</creatorcontrib><creatorcontrib>Eligulashvili, Victoria</creatorcontrib><creatorcontrib>Ricaurte, George A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>Neuropsychobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCann, Una D.</au><au>Eligulashvili, Victoria</au><au>Ricaurte, George A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>(±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Clinical Studies</atitle><jtitle>Neuropsychobiology</jtitle><addtitle>Neuropsychobiology</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>42</volume><issue>1</issue><spage>11</spage><epage>16</epage><pages>11-16</pages><issn>0302-282X</issn><eissn>1423-0224</eissn><isbn>9783805571104</isbn><isbn>3805571100</isbn><eisbn>9783318006094</eisbn><eisbn>3318006092</eisbn><coden>NPBYAL</coden><abstract>(±)3,4-Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) is a brain serotonergic neurotoxin in experimental animals, including nonhuman primates. It is also an increasingly popular recreational drug of abuse, and doses of MDMA that are used recreationally overlap with those that produce serotonin (5-HT) neurotoxicity in animals. Studies in human MDMA users probing for evidence of brain serotonergic neurotoxicity indicate that some MDMA users may incur MDMA-related 5-HT neural injury and, possibly, functional sequelae. In particular, MDMA users have selective decrements in cerebrospinal fluid 5-hydroxyindoleacetic acid and brain 5-HT transporters, similar to nonhuman primates with documented MDMA-induced neurotoxicity. Functional abnormalities seen in MDMA users that may be related to 5- HT injury include cognitive deficits, altered sleep architecture, altered neuroendocrine function, altered behavioral responses to 5-HT selective drugs, and increased impulsivity. Additional studies in animals, as well as longitudinal and epidemiological studies in MDMA users, are required to confirm and extend the present data, and to determine whether MDMA users are at increased risk for developing neuropsychiatric illness as they age.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10867551</pmid><doi>10.1159/000026665</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0302-282X |
| ispartof | Neuropsychobiology, 2000-01, Vol.42 (1), p.11-16 |
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| language | eng |
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| source | MEDLINE; Karger Journals |
| subjects | Animals Behavioral psychophysiology Biological and medical sciences Fundamental and applied biological sciences. Psychology Hallucinogens - toxicity Humans N-Methyl-3,4-methylenedioxyamphetamine - toxicity Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - pathology Neurotoxicity Syndromes - psychology Neurotransmission and behavior Primates Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Serotonin - metabolism Serotonin - physiology Serotonin Agents - toxicity |
| title | (±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Clinical Studies |
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