Serum Neopterin and Somatization in Women with Chemical Intolerance, Depressives, and Normals
The symptom of intolerance to low levels of environmental chemicals (CI, chemical intolerance) is a feature of several controversial polysymptomatic conditions that overlap symptomatically with depression and somatization, i.e., chronic fatigue syndrome, fibromyalgia, multiple chemical sensitivity,...
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| Veröffentlicht in: | Neuropsychobiology 1998-01, Vol.38 (1), p.13-18 |
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| creator | Bell, Iris R. Patarca, Roberto Baldwin, Carol M. Klimas, Nancy G. Schwartz, Gary E.R. Hardin, Elizabeth E. |
| description | The symptom of intolerance to low levels of environmental chemicals (CI, chemical intolerance) is a feature of several controversial polysymptomatic conditions that overlap symptomatically with depression and somatization, i.e., chronic fatigue syndrome, fibromyalgia, multiple chemical sensitivity, and Persian Gulf syndrome. These syndromes can involve many somatic symptoms consistent with possible inflammation. Immunological or neurogenic triggering might account for such inflammation. Serum neopterin, which has an inverse relationship with l-tryptophan availability, may offer a marker of inflammation and macrophage/monocyte activation. This study compared middle-aged women with CI (who had high levels of affective distress; n = 14), depressives without CI (n = 10), and normals (n = 11). Groups did not differ in 4 p.m. resting levels of serum neopterin. However, the CI alone had strong positive correlations between neopterin and all of the scales measuring somatization. These preliminary findings suggest the need for additional research on biological correlates of ‘unexplained’ multiple somatic symptoms in subtypes of apparent somatizing disorders. |
| doi_str_mv | 10.1159/000026511 |
| format | Article |
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These syndromes can involve many somatic symptoms consistent with possible inflammation. Immunological or neurogenic triggering might account for such inflammation. Serum neopterin, which has an inverse relationship with l-tryptophan availability, may offer a marker of inflammation and macrophage/monocyte activation. This study compared middle-aged women with CI (who had high levels of affective distress; n = 14), depressives without CI (n = 10), and normals (n = 11). Groups did not differ in 4 p.m. resting levels of serum neopterin. However, the CI alone had strong positive correlations between neopterin and all of the scales measuring somatization. These preliminary findings suggest the need for additional research on biological correlates of ‘unexplained’ multiple somatic symptoms in subtypes of apparent somatizing disorders.</description><identifier>ISSN: 0302-282X</identifier><identifier>EISSN: 1423-0224</identifier><identifier>DOI: 10.1159/000026511</identifier><identifier>PMID: 9701717</identifier><identifier>CODEN: NPBYAL</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Adult and adolescent clinical studies ; Analysis of Variance ; Antidepressive Agents - therapeutic use ; Biological and medical sciences ; Biological PsychiatryOriginal Paper ; Biomarkers - blood ; Chi-Square Distribution ; Depressive Disorder - blood ; Depressive Disorder - drug therapy ; Electroencephalography ; Female ; Humans ; Inflammation - blood ; Inflammation Mediators - metabolism ; Medical sciences ; Middle Aged ; Multiple Chemical Sensitivity - blood ; Neopterin - blood ; Psychiatric Status Rating Scales ; Psychology. 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These syndromes can involve many somatic symptoms consistent with possible inflammation. Immunological or neurogenic triggering might account for such inflammation. Serum neopterin, which has an inverse relationship with l-tryptophan availability, may offer a marker of inflammation and macrophage/monocyte activation. This study compared middle-aged women with CI (who had high levels of affective distress; n = 14), depressives without CI (n = 10), and normals (n = 11). Groups did not differ in 4 p.m. resting levels of serum neopterin. However, the CI alone had strong positive correlations between neopterin and all of the scales measuring somatization. These preliminary findings suggest the need for additional research on biological correlates of ‘unexplained’ multiple somatic symptoms in subtypes of apparent somatizing disorders.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biological PsychiatryOriginal Paper</subject><subject>Biomarkers - blood</subject><subject>Chi-Square Distribution</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - drug therapy</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - blood</subject><subject>Inflammation Mediators - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Chemical Sensitivity - blood</subject><subject>Neopterin - blood</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. 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Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Somatoform Disorders - blood</topic><topic>Somatoform disorders. Psychosomatics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bell, Iris R.</creatorcontrib><creatorcontrib>Patarca, Roberto</creatorcontrib><creatorcontrib>Baldwin, Carol M.</creatorcontrib><creatorcontrib>Klimas, Nancy G.</creatorcontrib><creatorcontrib>Schwartz, Gary E.R.</creatorcontrib><creatorcontrib>Hardin, Elizabeth E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>Neuropsychobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bell, Iris R.</au><au>Patarca, Roberto</au><au>Baldwin, Carol M.</au><au>Klimas, Nancy G.</au><au>Schwartz, Gary E.R.</au><au>Hardin, Elizabeth E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Neopterin and Somatization in Women with Chemical Intolerance, Depressives, and Normals</atitle><jtitle>Neuropsychobiology</jtitle><addtitle>Neuropsychobiology</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>38</volume><issue>1</issue><spage>13</spage><epage>18</epage><pages>13-18</pages><issn>0302-282X</issn><eissn>1423-0224</eissn><coden>NPBYAL</coden><abstract>The symptom of intolerance to low levels of environmental chemicals (CI, chemical intolerance) is a feature of several controversial polysymptomatic conditions that overlap symptomatically with depression and somatization, i.e., chronic fatigue syndrome, fibromyalgia, multiple chemical sensitivity, and Persian Gulf syndrome. These syndromes can involve many somatic symptoms consistent with possible inflammation. Immunological or neurogenic triggering might account for such inflammation. Serum neopterin, which has an inverse relationship with l-tryptophan availability, may offer a marker of inflammation and macrophage/monocyte activation. This study compared middle-aged women with CI (who had high levels of affective distress; n = 14), depressives without CI (n = 10), and normals (n = 11). Groups did not differ in 4 p.m. resting levels of serum neopterin. However, the CI alone had strong positive correlations between neopterin and all of the scales measuring somatization. These preliminary findings suggest the need for additional research on biological correlates of ‘unexplained’ multiple somatic symptoms in subtypes of apparent somatizing disorders.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>9701717</pmid><doi>10.1159/000026511</doi><tpages>6</tpages></addata></record> |
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| ispartof | Neuropsychobiology, 1998-01, Vol.38 (1), p.13-18 |
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| source | MEDLINE; Karger Journals |
| subjects | Adult Adult and adolescent clinical studies Analysis of Variance Antidepressive Agents - therapeutic use Biological and medical sciences Biological PsychiatryOriginal Paper Biomarkers - blood Chi-Square Distribution Depressive Disorder - blood Depressive Disorder - drug therapy Electroencephalography Female Humans Inflammation - blood Inflammation Mediators - metabolism Medical sciences Middle Aged Multiple Chemical Sensitivity - blood Neopterin - blood Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Somatoform Disorders - blood Somatoform disorders. Psychosomatics |
| title | Serum Neopterin and Somatization in Women with Chemical Intolerance, Depressives, and Normals |
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