A Possible Role for Acetylcholine in the Dialogue between Thymocytes and Thymic Stroma
In this article we will review data suggesting that acetylcholine takes part in the mutual interplay between developing T cells and thymic epithelium, and thereby may influence the generation of the T-cell repertoire. In the first part we will recapitulate our findings according to which cholinergic...
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| Veröffentlicht in: | Neuroimmunomodulation 1999-01, Vol.6 (1-2), p.51-55 |
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| container_title | Neuroimmunomodulation |
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| creator | Rinner, I. Globerson, A. Kawashima, K. Korsatko, W. Schauenstein, K. |
| description | In this article we will review data suggesting that acetylcholine takes part in the mutual interplay between developing T cells and thymic epithelium, and thereby may influence the generation of the T-cell repertoire. In the first part we will recapitulate our findings according to which cholinergic agonists affect thymocyte apoptosis via a nicotinergic effect on thymic epithelial cells. In the second part we will present evidence that acetylcholine within the thymus is mainly derived from the thymocytes themselves, and that the production and release of this neurotransmitter is dependent on activation of thymic lymphocytes. |
| doi_str_mv | 10.1159/000026364 |
| format | Article |
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In the first part we will recapitulate our findings according to which cholinergic agonists affect thymocyte apoptosis via a nicotinergic effect on thymic epithelial cells. In the second part we will present evidence that acetylcholine within the thymus is mainly derived from the thymocytes themselves, and that the production and release of this neurotransmitter is dependent on activation of thymic lymphocytes.</description><identifier>ISSN: 1021-7401</identifier><identifier>ISBN: 3805567693</identifier><identifier>ISBN: 9783805567695</identifier><identifier>EISSN: 1423-0216</identifier><identifier>EISBN: 9783318003567</identifier><identifier>EISBN: 3318003565</identifier><identifier>DOI: 10.1159/000026364</identifier><identifier>PMID: 9876235</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Acetylcholine - physiology ; Animals ; Apoptosis ; Cells, Cultured ; Choline O-Acetyltransferase - genetics ; Choline O-Acetyltransferase - metabolism ; Coculture Techniques ; Epithelial Cells - cytology ; Male ; Paracrine Communication ; Polymerase Chain Reaction ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger - metabolism ; Stromal Cells - cytology ; T-Lymphocytes - cytology ; Thymus Gland - cytology</subject><ispartof>Neuroimmunomodulation, 1999-01, Vol.6 (1-2), p.51-55</ispartof><rights>1999 S. 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In the first part we will recapitulate our findings according to which cholinergic agonists affect thymocyte apoptosis via a nicotinergic effect on thymic epithelial cells. In the second part we will present evidence that acetylcholine within the thymus is mainly derived from the thymocytes themselves, and that the production and release of this neurotransmitter is dependent on activation of thymic lymphocytes.</description><subject>Acetylcholine - physiology</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Cells, Cultured</subject><subject>Choline O-Acetyltransferase - genetics</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>Coculture Techniques</subject><subject>Epithelial Cells - cytology</subject><subject>Male</subject><subject>Paracrine Communication</subject><subject>Polymerase Chain Reaction</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - metabolism</subject><subject>Stromal Cells - cytology</subject><subject>T-Lymphocytes - cytology</subject><subject>Thymus Gland - cytology</subject><issn>1021-7401</issn><issn>1423-0216</issn><isbn>3805567693</isbn><isbn>9783805567695</isbn><isbn>9783318003567</isbn><isbn>3318003565</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtv1DAQxs1LpS09cEZIVg9IHFJsz_p1XJUWKvUlKFyjxB53A0m82Fmh_e_rdpc9MYcZeX7ffJI_Qt5ydsK5tJ9YKaFAzZ6RI6sNADeMgVT6OdnnMwEVE1y9IAdgmCxbZeFlAWVZ6Rnjr8lBzr-KBTBu9sieNVoJkPvk55zexpy7tkf6LZYWYqJzh9O6d4vYdyPSbqTTAunnrunj_Qppi9NfxJHeLdZDdOsJM21G__TsHP0-pTg0b8ir0PQZj7bzkPw4P7s7_Vpd3ny5OJ1fVg6EnqrAwHkblNCet-g1COktSKZmADoY4XnQ3mgngbWMB2udsI3zxvCWS-9bOCQfNr7LFP-sME_10GWHfd-MGFe5VlaWsqIIP26ELpXvJgz1MnVDk9Y1Z_VjwPUu4KJ9vzVdtQP6nXIbWuHvNvx3k-4x7fi_6-P_0uuLqydBvfQBHgAUcoSZ</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Rinner, I.</creator><creator>Globerson, A.</creator><creator>Kawashima, K.</creator><creator>Korsatko, W.</creator><creator>Schauenstein, K.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990101</creationdate><title>A Possible Role for Acetylcholine in the Dialogue between Thymocytes and Thymic Stroma</title><author>Rinner, I. ; Globerson, A. ; Kawashima, K. ; Korsatko, W. ; Schauenstein, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-f03cd9f627d1bed7325d935064337f82d1f7d87c530b01f99c29acd881b15ddb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acetylcholine - physiology</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Cells, Cultured</topic><topic>Choline O-Acetyltransferase - genetics</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>Coculture Techniques</topic><topic>Epithelial Cells - cytology</topic><topic>Male</topic><topic>Paracrine Communication</topic><topic>Polymerase Chain Reaction</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - metabolism</topic><topic>Stromal Cells - cytology</topic><topic>T-Lymphocytes - cytology</topic><topic>Thymus Gland - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rinner, I.</creatorcontrib><creatorcontrib>Globerson, A.</creatorcontrib><creatorcontrib>Kawashima, K.</creatorcontrib><creatorcontrib>Korsatko, W.</creatorcontrib><creatorcontrib>Schauenstein, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroimmunomodulation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rinner, I.</au><au>Globerson, A.</au><au>Kawashima, K.</au><au>Korsatko, W.</au><au>Schauenstein, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Possible Role for Acetylcholine in the Dialogue between Thymocytes and Thymic Stroma</atitle><jtitle>Neuroimmunomodulation</jtitle><addtitle>Neuroimmunomodulation</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>6</volume><issue>1-2</issue><spage>51</spage><epage>55</epage><pages>51-55</pages><issn>1021-7401</issn><eissn>1423-0216</eissn><isbn>3805567693</isbn><isbn>9783805567695</isbn><eisbn>9783318003567</eisbn><eisbn>3318003565</eisbn><abstract>In this article we will review data suggesting that acetylcholine takes part in the mutual interplay between developing T cells and thymic epithelium, and thereby may influence the generation of the T-cell repertoire. In the first part we will recapitulate our findings according to which cholinergic agonists affect thymocyte apoptosis via a nicotinergic effect on thymic epithelial cells. In the second part we will present evidence that acetylcholine within the thymus is mainly derived from the thymocytes themselves, and that the production and release of this neurotransmitter is dependent on activation of thymic lymphocytes.</abstract><cop>Basel, Switzerland</cop><pmid>9876235</pmid><doi>10.1159/000026364</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neuroimmunomodulation, 1999-01, Vol.6 (1-2), p.51-55 |
| issn | 1021-7401 1423-0216 |
| language | eng |
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| source | MEDLINE; Karger Journals |
| subjects | Acetylcholine - physiology Animals Apoptosis Cells, Cultured Choline O-Acetyltransferase - genetics Choline O-Acetyltransferase - metabolism Coculture Techniques Epithelial Cells - cytology Male Paracrine Communication Polymerase Chain Reaction Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Stromal Cells - cytology T-Lymphocytes - cytology Thymus Gland - cytology |
| title | A Possible Role for Acetylcholine in the Dialogue between Thymocytes and Thymic Stroma |
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