Predictive Value of Serum Follicle-Stimulating Hormone Levels in the Differentiation between Hypogonadotropic Hypogonadism and Constitutional Delay of Puberty
Objective: Gonadotropin secretion was evaluated to predict hypogonadotropic hypogonadism (HH) in 36 children suspected of having HH. Methods: LH was measured for 24 h at 10-min intervals, and FSH and estradiol or testosterone at 1-hour intervals. Twenty boys (age 15.7, range 13.2–19.3 years) and 16...
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| Veröffentlicht in: | Hormone research 1998-06, Vol.49 (6), p.279-287 |
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| creator | Odink, Roelof J. Schoemaker, Joop Schoute, Erik Herdes, Erik Delemarre-van de Waal, Henriette A. |
| description | Objective: Gonadotropin secretion was evaluated to predict hypogonadotropic hypogonadism (HH) in 36 children suspected of having HH. Methods: LH was measured for 24 h at 10-min intervals, and FSH and estradiol or testosterone at 1-hour intervals. Twenty boys (age 15.7, range 13.2–19.3 years) and 16 girls (age 16.1, range 13.0–20.6 years) were studied. Results: LH pulses were detected in 9 boys and 5 girls. HH was confirmed in all 11 LH apulsatile boys and in 8 of 11 LH apulsatile girls. Random FSH values of ≤1.11 and ≤2.86 IU/l in boys and girls, respectively, discriminated patients with LH pulses from patients without (sensitivity for lack of LH pulses 97 and 100%, respectively). In boys testicular volume was not discriminatory. In 1 girl LH pulses were observed without estradiol production, suggesting LH neurosecretory dysfunction. Conclusions: Low FSH levels in adolescence are strongly related to a lack of LH pulses. Lack of LH pulses is highly suspect for HH. FSH may be a tool in the differentiation between HH and delayed puberty. |
| doi_str_mv | 10.1159/000023187 |
| format | Article |
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Methods: LH was measured for 24 h at 10-min intervals, and FSH and estradiol or testosterone at 1-hour intervals. Twenty boys (age 15.7, range 13.2–19.3 years) and 16 girls (age 16.1, range 13.0–20.6 years) were studied. Results: LH pulses were detected in 9 boys and 5 girls. HH was confirmed in all 11 LH apulsatile boys and in 8 of 11 LH apulsatile girls. Random FSH values of ≤1.11 and ≤2.86 IU/l in boys and girls, respectively, discriminated patients with LH pulses from patients without (sensitivity for lack of LH pulses 97 and 100%, respectively). In boys testicular volume was not discriminatory. In 1 girl LH pulses were observed without estradiol production, suggesting LH neurosecretory dysfunction. Conclusions: Low FSH levels in adolescence are strongly related to a lack of LH pulses. Lack of LH pulses is highly suspect for HH. FSH may be a tool in the differentiation between HH and delayed puberty.</description><identifier>ISSN: 1663-2818</identifier><identifier>ISSN: 0301-0163</identifier><identifier>EISSN: 1663-2826</identifier><identifier>DOI: 10.1159/000023187</identifier><identifier>PMID: 9623519</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adolescent ; Adult ; Diagnosis, Differential ; Estradiol - secretion ; Female ; Follicle Stimulating Hormone - blood ; Follicle Stimulating Hormone - secretion ; Follow-Up Studies ; Gonadotropins - deficiency ; Gonadotropins - physiology ; Humans ; Hypogonadism - diagnosis ; Hypogonadism - physiopathology ; Luteinizing Hormone - secretion ; Male ; Original Paper ; Predictive Value of Tests ; Puberty, Delayed - diagnosis ; Puberty, Delayed - physiopathology ; Testosterone - secretion</subject><ispartof>Hormone research, 1998-06, Vol.49 (6), p.279-287</ispartof><rights>1998 S. Karger AG, Basel</rights><rights>Copyright (c) 1998 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-5b15ec3609a289342626242aff397200cbeefe6d3d3292b9f50e182903d6a8033</citedby><cites>FETCH-LOGICAL-c328t-5b15ec3609a289342626242aff397200cbeefe6d3d3292b9f50e182903d6a8033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9623519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Odink, Roelof J.</creatorcontrib><creatorcontrib>Schoemaker, Joop</creatorcontrib><creatorcontrib>Schoute, Erik</creatorcontrib><creatorcontrib>Herdes, Erik</creatorcontrib><creatorcontrib>Delemarre-van de Waal, Henriette A.</creatorcontrib><title>Predictive Value of Serum Follicle-Stimulating Hormone Levels in the Differentiation between Hypogonadotropic Hypogonadism and Constitutional Delay of Puberty</title><title>Hormone research</title><addtitle>Horm Res Paediatr</addtitle><description>Objective: Gonadotropin secretion was evaluated to predict hypogonadotropic hypogonadism (HH) in 36 children suspected of having HH. Methods: LH was measured for 24 h at 10-min intervals, and FSH and estradiol or testosterone at 1-hour intervals. Twenty boys (age 15.7, range 13.2–19.3 years) and 16 girls (age 16.1, range 13.0–20.6 years) were studied. Results: LH pulses were detected in 9 boys and 5 girls. HH was confirmed in all 11 LH apulsatile boys and in 8 of 11 LH apulsatile girls. Random FSH values of ≤1.11 and ≤2.86 IU/l in boys and girls, respectively, discriminated patients with LH pulses from patients without (sensitivity for lack of LH pulses 97 and 100%, respectively). In boys testicular volume was not discriminatory. In 1 girl LH pulses were observed without estradiol production, suggesting LH neurosecretory dysfunction. Conclusions: Low FSH levels in adolescence are strongly related to a lack of LH pulses. Lack of LH pulses is highly suspect for HH. FSH may be a tool in the differentiation between HH and delayed puberty.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Diagnosis, Differential</subject><subject>Estradiol - secretion</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Follicle Stimulating Hormone - secretion</subject><subject>Follow-Up Studies</subject><subject>Gonadotropins - deficiency</subject><subject>Gonadotropins - physiology</subject><subject>Humans</subject><subject>Hypogonadism - diagnosis</subject><subject>Hypogonadism - physiopathology</subject><subject>Luteinizing Hormone - secretion</subject><subject>Male</subject><subject>Original Paper</subject><subject>Predictive Value of Tests</subject><subject>Puberty, Delayed - diagnosis</subject><subject>Puberty, Delayed - physiopathology</subject><subject>Testosterone - secretion</subject><issn>1663-2818</issn><issn>0301-0163</issn><issn>1663-2826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkU1r3DAQhkVpSEOaQ8-lICgEcnCjj7UsHcum6RYWEkjaq5Ht0VapLG31kbJ_pr81NrtsoTOHGeZ9Zhh4EXpHySdKa3VNpmCcyuYVOqNC8IpJJl4feyrfoIuUnmaMy0bR5hSdKsF4TdUZ-nsfYbB9ts-Af2hXAAeDHyCWEd8G52zvoHrIdixOZ-s3eBXiGDzgNTyDS9h6nH8CvrHGQASf7UQFjzvIfwA8Xu22YRO8HkKOYWv7fwObRqz9gJfBp2xzmde0wzfg9G5-4b50EPPuLTox2iW4ONRz9P32y-NyVa3vvn5bfl5XPWcyV3VHa-i5IEozqfiCiSkXTBvDVcMI6TsAA2LgA2eKdcrUBKhkivBBaEk4P0eX-7vbGH4XSLkdberBOe0hlNQ2SrEFVzP48T_wKZQ4vZ5aSoRiVHLRTNTVnupjSCmCabfRjjruJqidTWuPpk3sh8PF0o0wHMmDRZP-fq__0nED8ajvt18AggScCw</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>Odink, Roelof J.</creator><creator>Schoemaker, Joop</creator><creator>Schoute, Erik</creator><creator>Herdes, Erik</creator><creator>Delemarre-van de Waal, Henriette A.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19980601</creationdate><title>Predictive Value of Serum Follicle-Stimulating Hormone Levels in the Differentiation between Hypogonadotropic Hypogonadism and Constitutional Delay of Puberty</title><author>Odink, Roelof J. ; Schoemaker, Joop ; Schoute, Erik ; Herdes, Erik ; Delemarre-van de Waal, Henriette A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-5b15ec3609a289342626242aff397200cbeefe6d3d3292b9f50e182903d6a8033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Diagnosis, Differential</topic><topic>Estradiol - secretion</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Follicle Stimulating Hormone - secretion</topic><topic>Follow-Up Studies</topic><topic>Gonadotropins - deficiency</topic><topic>Gonadotropins - physiology</topic><topic>Humans</topic><topic>Hypogonadism - diagnosis</topic><topic>Hypogonadism - physiopathology</topic><topic>Luteinizing Hormone - secretion</topic><topic>Male</topic><topic>Original Paper</topic><topic>Predictive Value of Tests</topic><topic>Puberty, Delayed - diagnosis</topic><topic>Puberty, Delayed - physiopathology</topic><topic>Testosterone - secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Odink, Roelof J.</creatorcontrib><creatorcontrib>Schoemaker, Joop</creatorcontrib><creatorcontrib>Schoute, Erik</creatorcontrib><creatorcontrib>Herdes, Erik</creatorcontrib><creatorcontrib>Delemarre-van de Waal, Henriette A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Odink, Roelof J.</au><au>Schoemaker, Joop</au><au>Schoute, Erik</au><au>Herdes, Erik</au><au>Delemarre-van de Waal, Henriette A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive Value of Serum Follicle-Stimulating Hormone Levels in the Differentiation between Hypogonadotropic Hypogonadism and Constitutional Delay of Puberty</atitle><jtitle>Hormone research</jtitle><addtitle>Horm Res Paediatr</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>49</volume><issue>6</issue><spage>279</spage><epage>287</epage><pages>279-287</pages><issn>1663-2818</issn><issn>0301-0163</issn><eissn>1663-2826</eissn><abstract>Objective: Gonadotropin secretion was evaluated to predict hypogonadotropic hypogonadism (HH) in 36 children suspected of having HH. Methods: LH was measured for 24 h at 10-min intervals, and FSH and estradiol or testosterone at 1-hour intervals. Twenty boys (age 15.7, range 13.2–19.3 years) and 16 girls (age 16.1, range 13.0–20.6 years) were studied. Results: LH pulses were detected in 9 boys and 5 girls. HH was confirmed in all 11 LH apulsatile boys and in 8 of 11 LH apulsatile girls. Random FSH values of ≤1.11 and ≤2.86 IU/l in boys and girls, respectively, discriminated patients with LH pulses from patients without (sensitivity for lack of LH pulses 97 and 100%, respectively). In boys testicular volume was not discriminatory. In 1 girl LH pulses were observed without estradiol production, suggesting LH neurosecretory dysfunction. Conclusions: Low FSH levels in adolescence are strongly related to a lack of LH pulses. Lack of LH pulses is highly suspect for HH. FSH may be a tool in the differentiation between HH and delayed puberty.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>9623519</pmid><doi>10.1159/000023187</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1663-2818 |
| ispartof | Hormone research, 1998-06, Vol.49 (6), p.279-287 |
| issn | 1663-2818 0301-0163 1663-2826 |
| language | eng |
| recordid | cdi_karger_primary_23187 |
| source | MEDLINE; Karger Journals Complete; Alma/SFX Local Collection |
| subjects | Adolescent Adult Diagnosis, Differential Estradiol - secretion Female Follicle Stimulating Hormone - blood Follicle Stimulating Hormone - secretion Follow-Up Studies Gonadotropins - deficiency Gonadotropins - physiology Humans Hypogonadism - diagnosis Hypogonadism - physiopathology Luteinizing Hormone - secretion Male Original Paper Predictive Value of Tests Puberty, Delayed - diagnosis Puberty, Delayed - physiopathology Testosterone - secretion |
| title | Predictive Value of Serum Follicle-Stimulating Hormone Levels in the Differentiation between Hypogonadotropic Hypogonadism and Constitutional Delay of Puberty |
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