Expression of Cochlin mRNA Splice Variants in the Inner Ear

Proteomic analysis of inner ear proteins revealed unique properties of cochlin, encoded by the COCH gene. We detected 3 cochlin isoforms, p63s, p44s and p40s, in the inner ear tissue and a short 16-kDa isoform, cochlin-tomoprotein (CTP), in the perilymph. The role of the cochlin isoforms has not bee...

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Veröffentlicht in:	Audiology & neurotology 2010-01, Vol.15 (2), p.88-96
Hauptverfasser:	Sekine, Kuwon, Ikezono, Tetsuo, Matsumura, Tomohiro, Shindo, Susumu, Watanabe, Atsushi, Li, Lishu, Pawankar, Ruby, Nishino, Takeshi, Yagi, Toshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics Animals Audiology Biological and medical sciences Blotting, Western Cattle Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ear, Inner - metabolism Ears & hearing Exons - genetics Extracellular Matrix Proteins Gene expression Gene Expression - physiology Genetic Variation - genetics Humans Introns - genetics Medical sciences Myocardium - metabolism Non tumoral diseases Original Paper Otorhinolaryngology. Stomatology Perilymph - metabolism Protein Isoforms - genetics Proteins - genetics Rats Rats, Sprague-Dawley Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA, Messenger - genetics Sequence Analysis, DNA Species Specificity Spleen - metabolism Transcription, Genetic - genetics
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