Measurement of the Amounts of Elastic Fibers in the Skin and Temporal Arteries of Healthy Aged Individuals by Automated Image Analysis
Background: A quantitative study of dermal and arterial elastic fibers as a function of age was carried out by computerized image analysis. Objective: We investigated whether any parallelism can be established between the morphometric parameters of elastic fibers from the skin and the temporal arter...
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| Veröffentlicht in: | Gerontology (Basel) 1998, Vol.44 (6), p.318-323 |
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| creator | Gogly, B. Godeau, G. Septier, D. Hornebeck, W. Pellat, B. Jeandel, C. |
| description | Background: A quantitative study of dermal and arterial elastic fibers as a function of age was carried out by computerized image analysis. Objective: We investigated whether any parallelism can be established between the morphometric parameters of elastic fibers from the skin and the temporal artery in elderly subjects. Methods: we quantitated the skin elastic fibers of the reticular dermis and the elastic fibers of the temporal artey using a specific staining procedure followed by automated image analysis in 16 subjects of age range 63–87 years. Results: There was a good correlation between the area fraction occupied by the elastic fibers in the unexposed skin (inner part of the upper arm) and aging (r = 0.669, p < 0.01). The area fraction occupied by elastic fibers in unexposed skin was correlated with the area fraction occupied by elastic fibers in the deep part of the temporal artery (r = 0.498, p < 0.05). Actinic elastosis affected both tissues, but there was no correlation between the amount of elastotic material in the exposed skin and the area fraction of elastic fibers in the superficial part of the temporal artery. Conclusion: We provided evidence that in sun-protected tissues the area fraction occupied by elastic fibers in dermis and deep part of the temporal artery showed a significant correlation. We proposed that skin biopsies were a valuable diagnostic tool for predicting arterial wall abnormalities of elastic fibers. |
| doi_str_mv | 10.1159/000022035 |
| format | Article |
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Objective: We investigated whether any parallelism can be established between the morphometric parameters of elastic fibers from the skin and the temporal artery in elderly subjects. Methods: we quantitated the skin elastic fibers of the reticular dermis and the elastic fibers of the temporal artey using a specific staining procedure followed by automated image analysis in 16 subjects of age range 63–87 years. Results: There was a good correlation between the area fraction occupied by the elastic fibers in the unexposed skin (inner part of the upper arm) and aging (r = 0.669, p < 0.01). The area fraction occupied by elastic fibers in unexposed skin was correlated with the area fraction occupied by elastic fibers in the deep part of the temporal artery (r = 0.498, p < 0.05). Actinic elastosis affected both tissues, but there was no correlation between the amount of elastotic material in the exposed skin and the area fraction of elastic fibers in the superficial part of the temporal artery. Conclusion: We provided evidence that in sun-protected tissues the area fraction occupied by elastic fibers in dermis and deep part of the temporal artery showed a significant correlation. We proposed that skin biopsies were a valuable diagnostic tool for predicting arterial wall abnormalities of elastic fibers.</description><identifier>ISSN: 0304-324X</identifier><identifier>EISSN: 1423-0003</identifier><identifier>DOI: 10.1159/000022035</identifier><identifier>PMID: 9813430</identifier><identifier>CODEN: GERNDJ</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Aged ; Aged, 80 and over ; Aging - physiology ; Biological and medical sciences ; Development. Metamorphosis. Moult. 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Karger AG Nov/Dec 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-3136b5165f053ed56b0df0750295e5be71f854d6dafbc19ab05cab7e2a65657f3</citedby><cites>FETCH-LOGICAL-c449t-3136b5165f053ed56b0df0750295e5be71f854d6dafbc19ab05cab7e2a65657f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2430,4025,27928,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1583703$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9813430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gogly, B.</creatorcontrib><creatorcontrib>Godeau, G.</creatorcontrib><creatorcontrib>Septier, D.</creatorcontrib><creatorcontrib>Hornebeck, W.</creatorcontrib><creatorcontrib>Pellat, B.</creatorcontrib><creatorcontrib>Jeandel, C.</creatorcontrib><title>Measurement of the Amounts of Elastic Fibers in the Skin and Temporal Arteries of Healthy Aged Individuals by Automated Image Analysis</title><title>Gerontology (Basel)</title><addtitle>Gerontology</addtitle><description>Background: A quantitative study of dermal and arterial elastic fibers as a function of age was carried out by computerized image analysis. Objective: We investigated whether any parallelism can be established between the morphometric parameters of elastic fibers from the skin and the temporal artery in elderly subjects. Methods: we quantitated the skin elastic fibers of the reticular dermis and the elastic fibers of the temporal artey using a specific staining procedure followed by automated image analysis in 16 subjects of age range 63–87 years. Results: There was a good correlation between the area fraction occupied by the elastic fibers in the unexposed skin (inner part of the upper arm) and aging (r = 0.669, p < 0.01). The area fraction occupied by elastic fibers in unexposed skin was correlated with the area fraction occupied by elastic fibers in the deep part of the temporal artery (r = 0.498, p < 0.05). Actinic elastosis affected both tissues, but there was no correlation between the amount of elastotic material in the exposed skin and the area fraction of elastic fibers in the superficial part of the temporal artery. Conclusion: We provided evidence that in sun-protected tissues the area fraction occupied by elastic fibers in dermis and deep part of the temporal artery showed a significant correlation. We proposed that skin biopsies were a valuable diagnostic tool for predicting arterial wall abnormalities of elastic fibers.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Development. Metamorphosis. Moult. Ageing</subject><subject>Elastic Tissue - anatomy & histology</subject><subject>Experimental Section</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Reference Values</subject><subject>Sex Characteristics</subject><subject>Skin - anatomy & histology</subject><subject>Skin - radiation effects</subject><subject>Sunlight</subject><subject>Temporal Arteries - anatomy & histology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0304-324X</issn><issn>1423-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkU2LFDEQhoMo6-zqwbMIQUTw0FrpJN3Tx2GZ_YAVQVfw1lQ61bPZ7Y8xSQvzB_Z3m_lgFsRckqr3qbcqFGNvBHwWQldfIJ08B6mfsZlQucxSLJ-zGUhQmczVr5fsNIT7lIRcwAk7qeZCKgkz9viVMEyeehoiH1se74gv-nEaYtiGyw5DdA2_cIZ84G7YAT8e0gMHy2-pX48eO77wkbyjXc0VYRfvNnyxIsuvB-v-ODthF7hJuSmOPcat0OMqtRqw2wQXXrEXbULo9eE-Yz8vlrfnV9nNt8vr88VN1ihVxUwKWRgtCt2ClmR1YcC2UGrIK03aUCnauVa2sNiaRlRoQDdoSsqx0IUuW3nGPu591378PVGIde9CQ12HA41TqEsAVYLQCXz_D3g_Tj5NG-q8VIWs5lWVoE97qPFjCJ7aeu1dj35TC6i3i6mPi0nsu4PhZHqyR_KwiaR_OOgYGuxaj0PjwpOhnssS5NNcD-hX5I_65fL7rk-9tttfvv0vtJ_kL2hlqNw</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Gogly, B.</creator><creator>Godeau, G.</creator><creator>Septier, D.</creator><creator>Hornebeck, W.</creator><creator>Pellat, B.</creator><creator>Jeandel, C.</creator><general>Karger</general><general>S. 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Metamorphosis. Moult. Ageing</topic><topic>Elastic Tissue - anatomy & histology</topic><topic>Experimental Section</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Reference Values</topic><topic>Sex Characteristics</topic><topic>Skin - anatomy & histology</topic><topic>Skin - radiation effects</topic><topic>Sunlight</topic><topic>Temporal Arteries - anatomy & histology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gogly, B.</creatorcontrib><creatorcontrib>Godeau, G.</creatorcontrib><creatorcontrib>Septier, D.</creatorcontrib><creatorcontrib>Hornebeck, W.</creatorcontrib><creatorcontrib>Pellat, B.</creatorcontrib><creatorcontrib>Jeandel, C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Social Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Gerontology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gogly, B.</au><au>Godeau, G.</au><au>Septier, D.</au><au>Hornebeck, W.</au><au>Pellat, B.</au><au>Jeandel, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of the Amounts of Elastic Fibers in the Skin and Temporal Arteries of Healthy Aged Individuals by Automated Image Analysis</atitle><jtitle>Gerontology (Basel)</jtitle><addtitle>Gerontology</addtitle><date>1998</date><risdate>1998</risdate><volume>44</volume><issue>6</issue><spage>318</spage><epage>323</epage><pages>318-323</pages><issn>0304-324X</issn><eissn>1423-0003</eissn><coden>GERNDJ</coden><abstract>Background: A quantitative study of dermal and arterial elastic fibers as a function of age was carried out by computerized image analysis. Objective: We investigated whether any parallelism can be established between the morphometric parameters of elastic fibers from the skin and the temporal artery in elderly subjects. Methods: we quantitated the skin elastic fibers of the reticular dermis and the elastic fibers of the temporal artey using a specific staining procedure followed by automated image analysis in 16 subjects of age range 63–87 years. Results: There was a good correlation between the area fraction occupied by the elastic fibers in the unexposed skin (inner part of the upper arm) and aging (r = 0.669, p < 0.01). The area fraction occupied by elastic fibers in unexposed skin was correlated with the area fraction occupied by elastic fibers in the deep part of the temporal artery (r = 0.498, p < 0.05). Actinic elastosis affected both tissues, but there was no correlation between the amount of elastotic material in the exposed skin and the area fraction of elastic fibers in the superficial part of the temporal artery. Conclusion: We provided evidence that in sun-protected tissues the area fraction occupied by elastic fibers in dermis and deep part of the temporal artery showed a significant correlation. We proposed that skin biopsies were a valuable diagnostic tool for predicting arterial wall abnormalities of elastic fibers.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>9813430</pmid><doi>10.1159/000022035</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Aging - physiology Biological and medical sciences Development. Metamorphosis. Moult. Ageing Elastic Tissue - anatomy & histology Experimental Section Female Fundamental and applied biological sciences. Psychology Humans Image Processing, Computer-Assisted Male Middle Aged Reference Values Sex Characteristics Skin - anatomy & histology Skin - radiation effects Sunlight Temporal Arteries - anatomy & histology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Measurement of the Amounts of Elastic Fibers in the Skin and Temporal Arteries of Healthy Aged Individuals by Automated Image Analysis |
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