Caffeic Acid Phenethyl Ester Induces Apoptosis of Human Pancreatic Cancer Cells Involving Caspase and Mitochondrial Dysfunction

Aims: This study aimed to investigate the effect of caffeic acid phenethyl ester (CAPE), an active component isolated from honeybee propolis, in inducing apoptosis in human pancreatic cancer cells. Methods: Inhibition of viability of BxPC-3 and PANC-1 cell lines induced by CAPE was estimated by a tr...

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Veröffentlicht in:	Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2008-01, Vol.8 (6), p.566-576
Hauptverfasser:	Chen, Ming-Jen, Chang, Wen-Hsiung, Lin, Ching-Chung, Liu, Chia-Yuan, Wang, Tsang-En, Chu, Cheng-Hsin, Shih, Shou-Chuan, Chen, Yu-Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Apoptosis - drug effects Caffeic Acids - pharmacology Caspases - metabolism Cell Line, Tumor Cell Survival - drug effects DNA Fragmentation - drug effects Dose-Response Relationship, Drug Humans Membrane Potential, Mitochondrial - drug effects Mitochondria - physiology Original Paper Pancreatic cancer Pancreatic Neoplasms - drug therapy Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - pharmacology Substrate Specificity Time Factors
Online-Zugang:	Volltext
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