Impact of Body Mass Index and Obesity on Clinical Response to Systemic Treatment for Psoriasis
Objective: Our aim was to assess the role of the body mass index (BMI) in the clinical response to systemic treatment for psoriasis. Methods: A nationwide cohort study of patients receiving a new systemic treatment for plaque psoriasis at reference centres in Italy was conducted. Information was gat...
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| Veröffentlicht in: | Dermatology (Basel) 2008-01, Vol.217 (4), p.365-373 |
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| creator | Naldi, Luigi Addis, Antonio Chimenti, Sergio Giannetti, Alberto Picardo, Mauro Tomino, Carlo Maccarone, Mara Chatenoud, Liliane Bertuccio, Paola Caggese, Eugenia Cuscito, Rosanna |
| description | Objective: Our aim was to assess the role of the body mass index (BMI) in the clinical response to systemic treatment for psoriasis. Methods: A nationwide cohort study of patients receiving a new systemic treatment for plaque psoriasis at reference centres in Italy was conducted. Information was gathered through a web-based electronic form. Patients being maintained on the same medication and with data available at 8 and 16 weeks by March 31, 2007, were eligible. The outcome was a reduction in the Psoriasis Area Severity Index (PASI) of at least 75% at follow-up compared to baseline (PASI-75). Results: Out of 8,072 patients enrolled, 2,368 were eligible and analysable at 8 weeks and 2,042 at 16 weeks. PASI-75 was achieved by 819 patients (34.5%) at 8 weeks and 1,034 (50.6%) at 16 weeks. The proportion steadily decreased with increased values of BMI. Compared to normal weight (BMI = 20–24) the adjusted odds ratio for achieving PASI-75 in obese patients was 0.73 (95% CI = 0.58–0.93) at 8 weeks and 0.62 (95% CI = 0.49–0.79) at 16 weeks. The impact of the BMI did not show remarkable variations according to the drug prescribed at entry. Conclusion: The BMI affects the early clinical response to systemic treatment for psoriasis. |
| doi_str_mv | 10.1159/000156599 |
| format | Article |
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Methods: A nationwide cohort study of patients receiving a new systemic treatment for plaque psoriasis at reference centres in Italy was conducted. Information was gathered through a web-based electronic form. Patients being maintained on the same medication and with data available at 8 and 16 weeks by March 31, 2007, were eligible. The outcome was a reduction in the Psoriasis Area Severity Index (PASI) of at least 75% at follow-up compared to baseline (PASI-75). Results: Out of 8,072 patients enrolled, 2,368 were eligible and analysable at 8 weeks and 2,042 at 16 weeks. PASI-75 was achieved by 819 patients (34.5%) at 8 weeks and 1,034 (50.6%) at 16 weeks. The proportion steadily decreased with increased values of BMI. Compared to normal weight (BMI = 20–24) the adjusted odds ratio for achieving PASI-75 in obese patients was 0.73 (95% CI = 0.58–0.93) at 8 weeks and 0.62 (95% CI = 0.49–0.79) at 16 weeks. The impact of the BMI did not show remarkable variations according to the drug prescribed at entry. Conclusion: The BMI affects the early clinical response to systemic treatment for psoriasis.</description><identifier>ISSN: 1018-8665</identifier><identifier>EISSN: 1421-9832</identifier><identifier>DOI: 10.1159/000156599</identifier><identifier>PMID: 18810241</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Body mass index ; Clinical and Laboratory Studies ; Dermatology ; Medical treatment ; Obesity ; Psoriasis</subject><ispartof>Dermatology (Basel), 2008-01, Vol.217 (4), p.365-373</ispartof><rights>2008 S. Karger AG, Basel</rights><rights>Copyright (c) 2008 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c304t-9904926665cc77747f0fda02564a9c9a46471fa667b30f629ad836f55f50a82c3</citedby><cites>FETCH-LOGICAL-c304t-9904926665cc77747f0fda02564a9c9a46471fa667b30f629ad836f55f50a82c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids></links><search><creatorcontrib>Naldi, Luigi</creatorcontrib><creatorcontrib>Addis, Antonio</creatorcontrib><creatorcontrib>Chimenti, Sergio</creatorcontrib><creatorcontrib>Giannetti, Alberto</creatorcontrib><creatorcontrib>Picardo, Mauro</creatorcontrib><creatorcontrib>Tomino, Carlo</creatorcontrib><creatorcontrib>Maccarone, Mara</creatorcontrib><creatorcontrib>Chatenoud, Liliane</creatorcontrib><creatorcontrib>Bertuccio, Paola</creatorcontrib><creatorcontrib>Caggese, Eugenia</creatorcontrib><creatorcontrib>Cuscito, Rosanna</creatorcontrib><title>Impact of Body Mass Index and Obesity on Clinical Response to Systemic Treatment for Psoriasis</title><title>Dermatology (Basel)</title><addtitle>Dermatology</addtitle><description>Objective: Our aim was to assess the role of the body mass index (BMI) in the clinical response to systemic treatment for psoriasis. Methods: A nationwide cohort study of patients receiving a new systemic treatment for plaque psoriasis at reference centres in Italy was conducted. Information was gathered through a web-based electronic form. Patients being maintained on the same medication and with data available at 8 and 16 weeks by March 31, 2007, were eligible. The outcome was a reduction in the Psoriasis Area Severity Index (PASI) of at least 75% at follow-up compared to baseline (PASI-75). Results: Out of 8,072 patients enrolled, 2,368 were eligible and analysable at 8 weeks and 2,042 at 16 weeks. PASI-75 was achieved by 819 patients (34.5%) at 8 weeks and 1,034 (50.6%) at 16 weeks. The proportion steadily decreased with increased values of BMI. Compared to normal weight (BMI = 20–24) the adjusted odds ratio for achieving PASI-75 in obese patients was 0.73 (95% CI = 0.58–0.93) at 8 weeks and 0.62 (95% CI = 0.49–0.79) at 16 weeks. The impact of the BMI did not show remarkable variations according to the drug prescribed at entry. Conclusion: The BMI affects the early clinical response to systemic treatment for psoriasis.</description><subject>Body mass index</subject><subject>Clinical and Laboratory Studies</subject><subject>Dermatology</subject><subject>Medical treatment</subject><subject>Obesity</subject><subject>Psoriasis</subject><issn>1018-8665</issn><issn>1421-9832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0M9LwzAUB_AgipvTg3cPwYPgoZqkSdocdfhjMJnovFqyNJHOtpl5Gdj_3kpFwdN78D48vnwROqbkglKhLgkhVEih1A4aU85oovKU7fY7oXmSSylG6ABg3TOWZ2ofjWieU8I4HaPXWbPRJmLv8LUvO_ygAfCsLe0n1m2JFysLVeywb_G0rtrK6Bo_Wdj4FiyOHj93EG1TGbwMVsfGthE7H_Aj-FBpqOAQ7Tldgz36mRP0cnuznN4n88XdbHo1T0xKeEyUIlwx2Sc1JssynjniSk2YkFwrozSXPKNOS5mtUuIkU7rMU-mEcILonJl0gs6Gv5vgP7YWYtFUYGxd69b6LRSMqJRyyXp4-g-u_Ta0fbaCZYL2KhU9Oh-QCR4gWFdsQtXo0BWUFN-NF7-N9_ZksO86vNnwJ4fzF6zSeE8</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Naldi, Luigi</creator><creator>Addis, Antonio</creator><creator>Chimenti, Sergio</creator><creator>Giannetti, Alberto</creator><creator>Picardo, Mauro</creator><creator>Tomino, Carlo</creator><creator>Maccarone, Mara</creator><creator>Chatenoud, Liliane</creator><creator>Bertuccio, Paola</creator><creator>Caggese, Eugenia</creator><creator>Cuscito, Rosanna</creator><general>S. 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Methods: A nationwide cohort study of patients receiving a new systemic treatment for plaque psoriasis at reference centres in Italy was conducted. Information was gathered through a web-based electronic form. Patients being maintained on the same medication and with data available at 8 and 16 weeks by March 31, 2007, were eligible. The outcome was a reduction in the Psoriasis Area Severity Index (PASI) of at least 75% at follow-up compared to baseline (PASI-75). Results: Out of 8,072 patients enrolled, 2,368 were eligible and analysable at 8 weeks and 2,042 at 16 weeks. PASI-75 was achieved by 819 patients (34.5%) at 8 weeks and 1,034 (50.6%) at 16 weeks. The proportion steadily decreased with increased values of BMI. Compared to normal weight (BMI = 20–24) the adjusted odds ratio for achieving PASI-75 in obese patients was 0.73 (95% CI = 0.58–0.93) at 8 weeks and 0.62 (95% CI = 0.49–0.79) at 16 weeks. The impact of the BMI did not show remarkable variations according to the drug prescribed at entry. Conclusion: The BMI affects the early clinical response to systemic treatment for psoriasis.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>18810241</pmid><doi>10.1159/000156599</doi><tpages>9</tpages></addata></record> |
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| source | Karger Journals; Alma/SFX Local Collection |
| subjects | Body mass index Clinical and Laboratory Studies Dermatology Medical treatment Obesity Psoriasis |
| title | Impact of Body Mass Index and Obesity on Clinical Response to Systemic Treatment for Psoriasis |
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