Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA
Secretin is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Recently, it has been discussed that secretin deficiency may be implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion...
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| Veröffentlicht in: | Cytogenetic and genome research 2000-01, Vol.90 (1-2), p.47-52 |
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| creator | Whitmore, T.E. Holloway, J.L. Lofton-Day, C.E. Maurer, M.F. Chen, L. Quinton, T.J. Vincent, J.B. Scherer, S.W. Lok, S. |
| description | Secretin is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Recently, it has been discussed that secretin deficiency may be implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. In the present study, the human secretin gene (SCT) was isolated from a bacterial artificial chromosome genomic library. SCT contains four exons, with the protein coding regions spanning 713 bp of genomic DNA. Human SCT is similar structurally to the secretin genes of other species. Amino acid conservation, however, is most pronounced within the exon encoding the biologically active mature peptide. Northern blot analysis shows that human SCT transcripts are located in the spleen, intestinal tract, and brain. Radiation hybrid mapping places the SCT locus on chromosome 11p15.5. |
| doi_str_mv | 10.1159/000015658 |
| format | Article |
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Recently, it has been discussed that secretin deficiency may be implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. In the present study, the human secretin gene (SCT) was isolated from a bacterial artificial chromosome genomic library. SCT contains four exons, with the protein coding regions spanning 713 bp of genomic DNA. Human SCT is similar structurally to the secretin genes of other species. Amino acid conservation, however, is most pronounced within the exon encoding the biologically active mature peptide. Northern blot analysis shows that human SCT transcripts are located in the spleen, intestinal tract, and brain. Radiation hybrid mapping places the SCT locus on chromosome 11p15.5. </description><identifier>ISSN: 1424-8581</identifier><identifier>ISSN: 0301-0171</identifier><identifier>EISSN: 1424-859X</identifier><identifier>DOI: 10.1159/000015658</identifier><identifier>PMID: 11060443</identifier><identifier>CODEN: CGCGBR</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Amino Acid Sequence ; Base Sequence ; Biological and medical sciences ; Blotting, Northern ; chromosome 11 ; Chromosomes, Artificial, Bacterial ; Chromosomes, Human, Pair 11 - genetics ; Classical genetics, quantitative genetics, hybrids ; Cloning, Molecular ; Exons - genetics ; Expressed Sequence Tags ; Fundamental and applied biological sciences. Psychology ; Gene Expression Profiling ; Genes. Genome ; Genetics of eukaryotes. Biological and molecular evolution ; Genomic Library ; Human ; Humans ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Radiation Hybrid Mapping ; RNA, Messenger - analysis ; RNA, Messenger - genetics ; SCT gene ; secretin ; Secretin - chemistry ; Secretin - genetics ; Sequence Alignment</subject><ispartof>Cytogenetic and genome research, 2000-01, Vol.90 (1-2), p.47-52</ispartof><rights>2000 S. Karger AG, Basel</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2000 S. Karger AG, Basel.</rights><rights>Copyright S. 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Recently, it has been discussed that secretin deficiency may be implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. In the present study, the human secretin gene (SCT) was isolated from a bacterial artificial chromosome genomic library. SCT contains four exons, with the protein coding regions spanning 713 bp of genomic DNA. Human SCT is similar structurally to the secretin genes of other species. Amino acid conservation, however, is most pronounced within the exon encoding the biologically active mature peptide. Northern blot analysis shows that human SCT transcripts are located in the spleen, intestinal tract, and brain. Radiation hybrid mapping places the SCT locus on chromosome 11p15.5. </description><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>chromosome 11</subject><subject>Chromosomes, Artificial, Bacterial</subject><subject>Chromosomes, Human, Pair 11 - genetics</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Cloning, Molecular</subject><subject>Exons - genetics</subject><subject>Expressed Sequence Tags</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Profiling</subject><subject>Genes. Genome</subject><subject>Genetics of eukaryotes. 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Recently, it has been discussed that secretin deficiency may be implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. In the present study, the human secretin gene (SCT) was isolated from a bacterial artificial chromosome genomic library. SCT contains four exons, with the protein coding regions spanning 713 bp of genomic DNA. Human SCT is similar structurally to the secretin genes of other species. Amino acid conservation, however, is most pronounced within the exon encoding the biologically active mature peptide. Northern blot analysis shows that human SCT transcripts are located in the spleen, intestinal tract, and brain. Radiation hybrid mapping places the SCT locus on chromosome 11p15.5. </abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11060443</pmid><doi>10.1159/000015658</doi><tpages>6</tpages></addata></record> |
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| subjects | Amino Acid Sequence Base Sequence Biological and medical sciences Blotting, Northern chromosome 11 Chromosomes, Artificial, Bacterial Chromosomes, Human, Pair 11 - genetics Classical genetics, quantitative genetics, hybrids Cloning, Molecular Exons - genetics Expressed Sequence Tags Fundamental and applied biological sciences. Psychology Gene Expression Profiling Genes. Genome Genetics of eukaryotes. Biological and molecular evolution Genomic Library Human Humans Molecular and cellular biology Molecular genetics Molecular Sequence Data Radiation Hybrid Mapping RNA, Messenger - analysis RNA, Messenger - genetics SCT gene secretin Secretin - chemistry Secretin - genetics Sequence Alignment |
| title | Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA |
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