Atherothrombosis and Plaque Heterology: Different Location or a Unique Disease?
Formation of unstable plaques frequently results in atherothrombosis, the major cause for ischaemic stroke, myocardial infarction and peripheral arterial disease. Patients who have symptomatic thrombosis in one vascular bed are at increased risk of disease in other beds. However, the development of...
Gespeichert in:
| Veröffentlicht in: | Pathobiology (Basel) 2008-01, Vol.75 (4), p.209-225 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 225 |
|---|---|
| container_issue | 4 |
| container_start_page | 209 |
| container_title | Pathobiology (Basel) |
| container_volume | 75 |
| creator | Slevin, M. Wang, Q. Font, M. Angels Luque, A. Juan-Babot, Oriol Gaffney, J. Kumar, P. Kumar, S. Badimon, L. Krupinski, J. |
| description | Formation of unstable plaques frequently results in atherothrombosis, the major cause for ischaemic stroke, myocardial infarction and peripheral arterial disease. Patients who have symptomatic thrombosis in one vascular bed are at increased risk of disease in other beds. However, the development of the disease in carotid, coronary and peripheral arteries may have different pathophysiology suggesting that more complex treatment protocols may have to be designed to reduce plaque development at different locations. In this review we describe the known risk factors, compare the developmental features of coronary and carotid plaque development and determine their association with end-point ischaemic events. Differences are also seen in the genetic contribution to plaque development as well as in the deregulation of gene and protein expression and cellular signal transduction activity of active cells in regions susceptible to thrombosis. Differences between carotid and coronary artery plaque development might help to explain the differences in anatomopathological appearance and risk of rupture. |
| doi_str_mv | 10.1159/000132382 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_karger_primary_132382</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69259560</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-355095116e5a34c3f4344218f5b1c30d1ecb8d58a5d6945c56ebfc2a064386cf3</originalsourceid><addsrcrecordid>eNpd0E1LwzAYB_AgipvTg3eR4kHwUH3yaupFxqZOGMyDO5c0TbfOttGkPezbm9HhwFMeyO954Y_QJYZ7jHnyAACYEirJERpiRmgMJMHHoQbMYwIgB-jM-01gEgScogGWXAKIxyFajNu1cbZdO1tn1pc-Uk0efVTqpzPRzLThr7Kr7VM0LYvCONO00dxq1Za2iayLVLRsyh2dlt4ob57P0UmhKm8u9u8ILV9fPiezeL54e5-M57GmQrQx5RwSjrEwXFGmacEoYwTLgmdYU8ix0ZnMuVQ8FwnjmguTFZooEIxKoQs6Qrf93G9nw37fpnXptakq1Rjb-VQkhCdcQIA3_-DGdq4Jt6WEMEEZESSgux5pZ713pki_XVkrt00xpLuI07-Ig73eD-yy2uQHuc80gKsefCm3Mu4A-v5f1rJ9Ow</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>224634262</pqid></control><display><type>article</type><title>Atherothrombosis and Plaque Heterology: Different Location or a Unique Disease?</title><source>Karger Journals</source><source>MEDLINE</source><creator>Slevin, M. ; Wang, Q. ; Font, M. Angels ; Luque, A. ; Juan-Babot, Oriol ; Gaffney, J. ; Kumar, P. ; Kumar, S. ; Badimon, L. ; Krupinski, J.</creator><creatorcontrib>Slevin, M. ; Wang, Q. ; Font, M. Angels ; Luque, A. ; Juan-Babot, Oriol ; Gaffney, J. ; Kumar, P. ; Kumar, S. ; Badimon, L. ; Krupinski, J.</creatorcontrib><description>Formation of unstable plaques frequently results in atherothrombosis, the major cause for ischaemic stroke, myocardial infarction and peripheral arterial disease. Patients who have symptomatic thrombosis in one vascular bed are at increased risk of disease in other beds. However, the development of the disease in carotid, coronary and peripheral arteries may have different pathophysiology suggesting that more complex treatment protocols may have to be designed to reduce plaque development at different locations. In this review we describe the known risk factors, compare the developmental features of coronary and carotid plaque development and determine their association with end-point ischaemic events. Differences are also seen in the genetic contribution to plaque development as well as in the deregulation of gene and protein expression and cellular signal transduction activity of active cells in regions susceptible to thrombosis. Differences between carotid and coronary artery plaque development might help to explain the differences in anatomopathological appearance and risk of rupture.</description><identifier>ISSN: 1015-2008</identifier><identifier>EISSN: 1423-0291</identifier><identifier>DOI: 10.1159/000132382</identifier><identifier>PMID: 18580067</identifier><identifier>CODEN: PATHEF</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Blood clots ; Carotid Artery Diseases - blood ; Carotid Artery Diseases - genetics ; Carotid Artery Diseases - pathology ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Coronary Artery Disease - blood ; Coronary Artery Disease - genetics ; Coronary Artery Disease - pathology ; Coronary vessels ; Deregulation ; Female ; Health risks ; Humans ; Male ; Middle Aged ; Myocardial infarction ; Pathology ; Review ; Risk factors ; Rupture, Spontaneous ; Thromboembolism ; Tunica Intima - pathology</subject><ispartof>Pathobiology (Basel), 2008-01, Vol.75 (4), p.209-225</ispartof><rights>2008 S. Karger AG, Basel</rights><rights>Copyright 2008 S. Karger AG, Basel.</rights><rights>Copyright (c) 2008 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-355095116e5a34c3f4344218f5b1c30d1ecb8d58a5d6945c56ebfc2a064386cf3</citedby><cites>FETCH-LOGICAL-c366t-355095116e5a34c3f4344218f5b1c30d1ecb8d58a5d6945c56ebfc2a064386cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18580067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slevin, M.</creatorcontrib><creatorcontrib>Wang, Q.</creatorcontrib><creatorcontrib>Font, M. Angels</creatorcontrib><creatorcontrib>Luque, A.</creatorcontrib><creatorcontrib>Juan-Babot, Oriol</creatorcontrib><creatorcontrib>Gaffney, J.</creatorcontrib><creatorcontrib>Kumar, P.</creatorcontrib><creatorcontrib>Kumar, S.</creatorcontrib><creatorcontrib>Badimon, L.</creatorcontrib><creatorcontrib>Krupinski, J.</creatorcontrib><title>Atherothrombosis and Plaque Heterology: Different Location or a Unique Disease?</title><title>Pathobiology (Basel)</title><addtitle>Pathobiology</addtitle><description>Formation of unstable plaques frequently results in atherothrombosis, the major cause for ischaemic stroke, myocardial infarction and peripheral arterial disease. Patients who have symptomatic thrombosis in one vascular bed are at increased risk of disease in other beds. However, the development of the disease in carotid, coronary and peripheral arteries may have different pathophysiology suggesting that more complex treatment protocols may have to be designed to reduce plaque development at different locations. In this review we describe the known risk factors, compare the developmental features of coronary and carotid plaque development and determine their association with end-point ischaemic events. Differences are also seen in the genetic contribution to plaque development as well as in the deregulation of gene and protein expression and cellular signal transduction activity of active cells in regions susceptible to thrombosis. Differences between carotid and coronary artery plaque development might help to explain the differences in anatomopathological appearance and risk of rupture.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood clots</subject><subject>Carotid Artery Diseases - blood</subject><subject>Carotid Artery Diseases - genetics</subject><subject>Carotid Artery Diseases - pathology</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary vessels</subject><subject>Deregulation</subject><subject>Female</subject><subject>Health risks</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial infarction</subject><subject>Pathology</subject><subject>Review</subject><subject>Risk factors</subject><subject>Rupture, Spontaneous</subject><subject>Thromboembolism</subject><subject>Tunica Intima - pathology</subject><issn>1015-2008</issn><issn>1423-0291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0E1LwzAYB_AgipvTg3eR4kHwUH3yaupFxqZOGMyDO5c0TbfOttGkPezbm9HhwFMeyO954Y_QJYZ7jHnyAACYEirJERpiRmgMJMHHoQbMYwIgB-jM-01gEgScogGWXAKIxyFajNu1cbZdO1tn1pc-Uk0efVTqpzPRzLThr7Kr7VM0LYvCONO00dxq1Za2iayLVLRsyh2dlt4ob57P0UmhKm8u9u8ILV9fPiezeL54e5-M57GmQrQx5RwSjrEwXFGmacEoYwTLgmdYU8ix0ZnMuVQ8FwnjmguTFZooEIxKoQs6Qrf93G9nw37fpnXptakq1Rjb-VQkhCdcQIA3_-DGdq4Jt6WEMEEZESSgux5pZ713pki_XVkrt00xpLuI07-Ig73eD-yy2uQHuc80gKsefCm3Mu4A-v5f1rJ9Ow</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Slevin, M.</creator><creator>Wang, Q.</creator><creator>Font, M. Angels</creator><creator>Luque, A.</creator><creator>Juan-Babot, Oriol</creator><creator>Gaffney, J.</creator><creator>Kumar, P.</creator><creator>Kumar, S.</creator><creator>Badimon, L.</creator><creator>Krupinski, J.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Atherothrombosis and Plaque Heterology: Different Location or a Unique Disease?</title><author>Slevin, M. ; Wang, Q. ; Font, M. Angels ; Luque, A. ; Juan-Babot, Oriol ; Gaffney, J. ; Kumar, P. ; Kumar, S. ; Badimon, L. ; Krupinski, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-355095116e5a34c3f4344218f5b1c30d1ecb8d58a5d6945c56ebfc2a064386cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood clots</topic><topic>Carotid Artery Diseases - blood</topic><topic>Carotid Artery Diseases - genetics</topic><topic>Carotid Artery Diseases - pathology</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary vessels</topic><topic>Deregulation</topic><topic>Female</topic><topic>Health risks</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial infarction</topic><topic>Pathology</topic><topic>Review</topic><topic>Risk factors</topic><topic>Rupture, Spontaneous</topic><topic>Thromboembolism</topic><topic>Tunica Intima - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slevin, M.</creatorcontrib><creatorcontrib>Wang, Q.</creatorcontrib><creatorcontrib>Font, M. Angels</creatorcontrib><creatorcontrib>Luque, A.</creatorcontrib><creatorcontrib>Juan-Babot, Oriol</creatorcontrib><creatorcontrib>Gaffney, J.</creatorcontrib><creatorcontrib>Kumar, P.</creatorcontrib><creatorcontrib>Kumar, S.</creatorcontrib><creatorcontrib>Badimon, L.</creatorcontrib><creatorcontrib>Krupinski, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Pathobiology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slevin, M.</au><au>Wang, Q.</au><au>Font, M. Angels</au><au>Luque, A.</au><au>Juan-Babot, Oriol</au><au>Gaffney, J.</au><au>Kumar, P.</au><au>Kumar, S.</au><au>Badimon, L.</au><au>Krupinski, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atherothrombosis and Plaque Heterology: Different Location or a Unique Disease?</atitle><jtitle>Pathobiology (Basel)</jtitle><addtitle>Pathobiology</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>75</volume><issue>4</issue><spage>209</spage><epage>225</epage><pages>209-225</pages><issn>1015-2008</issn><eissn>1423-0291</eissn><coden>PATHEF</coden><abstract>Formation of unstable plaques frequently results in atherothrombosis, the major cause for ischaemic stroke, myocardial infarction and peripheral arterial disease. Patients who have symptomatic thrombosis in one vascular bed are at increased risk of disease in other beds. However, the development of the disease in carotid, coronary and peripheral arteries may have different pathophysiology suggesting that more complex treatment protocols may have to be designed to reduce plaque development at different locations. In this review we describe the known risk factors, compare the developmental features of coronary and carotid plaque development and determine their association with end-point ischaemic events. Differences are also seen in the genetic contribution to plaque development as well as in the deregulation of gene and protein expression and cellular signal transduction activity of active cells in regions susceptible to thrombosis. Differences between carotid and coronary artery plaque development might help to explain the differences in anatomopathological appearance and risk of rupture.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>18580067</pmid><doi>10.1159/000132382</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1015-2008 |
| ispartof | Pathobiology (Basel), 2008-01, Vol.75 (4), p.209-225 |
| issn | 1015-2008 1423-0291 |
| language | eng |
| recordid | cdi_karger_primary_132382 |
| source | Karger Journals; MEDLINE |
| subjects | Adult Aged Aged, 80 and over Blood clots Carotid Artery Diseases - blood Carotid Artery Diseases - genetics Carotid Artery Diseases - pathology Cholesterol, HDL - blood Cholesterol, LDL - blood Coronary Artery Disease - blood Coronary Artery Disease - genetics Coronary Artery Disease - pathology Coronary vessels Deregulation Female Health risks Humans Male Middle Aged Myocardial infarction Pathology Review Risk factors Rupture, Spontaneous Thromboembolism Tunica Intima - pathology |
| title | Atherothrombosis and Plaque Heterology: Different Location or a Unique Disease? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T16%3A30%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_karge&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Atherothrombosis%20and%20Plaque%20Heterology:%20Different%20Location%20or%20a%20Unique%20Disease?&rft.jtitle=Pathobiology%20(Basel)&rft.au=Slevin,%20M.&rft.date=2008-01-01&rft.volume=75&rft.issue=4&rft.spage=209&rft.epage=225&rft.pages=209-225&rft.issn=1015-2008&rft.eissn=1423-0291&rft.coden=PATHEF&rft_id=info:doi/10.1159/000132382&rft_dat=%3Cproquest_karge%3E69259560%3C/proquest_karge%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=224634262&rft_id=info:pmid/18580067&rfr_iscdi=true |