Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects
Background: Aging is associated with an increased risk for atherosclerosis in which endothelial dysfunction is an early marker. Objective: The purpose of this study was to determine if endothelial function is altered with increasing age in healthy subjects. Method: The study population consisted of...
Gespeichert in:
| Veröffentlicht in: | Gerontology (Basel) 2008-01, Vol.54 (3), p.153-156 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 156 |
|---|---|
| container_issue | 3 |
| container_start_page | 153 |
| container_title | Gerontology (Basel) |
| container_volume | 54 |
| creator | Yavuz, B.B. Yavuz, B. Sener, Dede D. Cankurtaran, M. Halil, M. Ulger, Z. Nazli, N. Kabakci, G. Aytemir, K. Tokgozoglu, L. Oto, A. Ariogul, S. |
| description | Background: Aging is associated with an increased risk for atherosclerosis in which endothelial dysfunction is an early marker. Objective: The purpose of this study was to determine if endothelial function is altered with increasing age in healthy subjects. Method: The study population consisted of 30 elderly and 36 younger subjects free from major cardiovascular risk factors. Transthoracic echocardiography was performed for each subject to rule out structural heart disease. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery via ultrasound. Results: Baseline characteristics of the elderly and the younger group were similar, except for age (mean age: 71.3 ± 5.8 vs. 26.5 ± 7.2). Transthoracic echocardiography was normal in all subjects. FMD of the elderly group was significantly lower than the younger group (7.9 ± 3.1 in the elderly, 10.8 ± 1.9 in the younger group, p < 0.001). A negative relationship was found between FMD and age (r = –0.528, p < 0.001). Conclusion: It can be concluded that endothelial function detected by FMD declines with increasing age in healthy human subjects. Advanced age is a predictor of impaired endothelial function. |
| doi_str_mv | 10.1159/000129064 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_karger_primary_129064</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70776911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-26c32f13ab928f12536a4fe3e40e4fccdcd1605f23d6f0a9f97da2703a9d79873</originalsourceid><addsrcrecordid>eNpd0M1LwzAYBvAgipvTg3eRICh4qL75aLsci84PEDyo4K1k-XCdWatJq_S_N7LiwFPg4cfzhgehQwIXhKTiEgAIFZDxLTQmnLIkBmwbjYEBTxjlryO0F8IyhkAJ7KIRmXJOUkrH6KnQX7JWRuPizeD7gIsQGlXJNibfVbvAs1o37cK4Sjp83Qfb1aqtmhpXNb4z0rWLHs-cNt71-KmbL41qwz7asdIFczC8E_RyM3u-ukseHm_vr4qHRLGMtAnNFKOWMDkXdGoJTVkmuTXMcDDcKqWVJhmkljKdWZDCilxLmgOTQudimrMJOlv3fvjmszOhLVdVUMY5WZumC2UOeZ4JQiI8-QeXTefr-LeS5jzuQBmP6HyNlG9C8MaWH75aSd-XBMrfmcu_maM9Hgq7-crojRx2jeB0ADIo6ayPG1fhz1FgAmiaRne0du_Svxm_KVrf-QFj_YvZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>274522234</pqid></control><display><type>article</type><title>Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects</title><source>MEDLINE</source><source>Karger Journals</source><source>Alma/SFX Local Collection</source><creator>Yavuz, B.B. ; Yavuz, B. ; Sener, Dede D. ; Cankurtaran, M. ; Halil, M. ; Ulger, Z. ; Nazli, N. ; Kabakci, G. ; Aytemir, K. ; Tokgozoglu, L. ; Oto, A. ; Ariogul, S.</creator><creatorcontrib>Yavuz, B.B. ; Yavuz, B. ; Sener, Dede D. ; Cankurtaran, M. ; Halil, M. ; Ulger, Z. ; Nazli, N. ; Kabakci, G. ; Aytemir, K. ; Tokgozoglu, L. ; Oto, A. ; Ariogul, S.</creatorcontrib><description>Background: Aging is associated with an increased risk for atherosclerosis in which endothelial dysfunction is an early marker. Objective: The purpose of this study was to determine if endothelial function is altered with increasing age in healthy subjects. Method: The study population consisted of 30 elderly and 36 younger subjects free from major cardiovascular risk factors. Transthoracic echocardiography was performed for each subject to rule out structural heart disease. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery via ultrasound. Results: Baseline characteristics of the elderly and the younger group were similar, except for age (mean age: 71.3 ± 5.8 vs. 26.5 ± 7.2). Transthoracic echocardiography was normal in all subjects. FMD of the elderly group was significantly lower than the younger group (7.9 ± 3.1 in the elderly, 10.8 ± 1.9 in the younger group, p < 0.001). A negative relationship was found between FMD and age (r = –0.528, p < 0.001). Conclusion: It can be concluded that endothelial function detected by FMD declines with increasing age in healthy human subjects. Advanced age is a predictor of impaired endothelial function.</description><identifier>ISSN: 0304-324X</identifier><identifier>EISSN: 1423-0003</identifier><identifier>DOI: 10.1159/000129064</identifier><identifier>PMID: 18441522</identifier><identifier>CODEN: GERNDJ</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Age Factors ; Aged ; Aging ; Biological and medical sciences ; Blood vessels ; Brachial Artery - physiology ; Cardiovascular disease ; Clinical Section ; Development. Metamorphosis. Moult. Ageing ; Echocardiography ; Endothelium, Vascular - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Gerontology ; Humans ; Male ; Middle Aged ; Reference Values ; Regional Blood Flow - physiology ; Risk factors ; Stroke Volume - physiology ; Vasodilation - physiology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Gerontology (Basel), 2008-01, Vol.54 (3), p.153-156</ispartof><rights>2008 S. Karger AG, Basel</rights><rights>2008 INIST-CNRS</rights><rights>(c) 2008 S. Karger AG, Basel.</rights><rights>Copyright (c) 2008 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-26c32f13ab928f12536a4fe3e40e4fccdcd1605f23d6f0a9f97da2703a9d79873</citedby><cites>FETCH-LOGICAL-c361t-26c32f13ab928f12536a4fe3e40e4fccdcd1605f23d6f0a9f97da2703a9d79873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2422,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20390255$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18441522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yavuz, B.B.</creatorcontrib><creatorcontrib>Yavuz, B.</creatorcontrib><creatorcontrib>Sener, Dede D.</creatorcontrib><creatorcontrib>Cankurtaran, M.</creatorcontrib><creatorcontrib>Halil, M.</creatorcontrib><creatorcontrib>Ulger, Z.</creatorcontrib><creatorcontrib>Nazli, N.</creatorcontrib><creatorcontrib>Kabakci, G.</creatorcontrib><creatorcontrib>Aytemir, K.</creatorcontrib><creatorcontrib>Tokgozoglu, L.</creatorcontrib><creatorcontrib>Oto, A.</creatorcontrib><creatorcontrib>Ariogul, S.</creatorcontrib><title>Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects</title><title>Gerontology (Basel)</title><addtitle>Gerontology</addtitle><description>Background: Aging is associated with an increased risk for atherosclerosis in which endothelial dysfunction is an early marker. Objective: The purpose of this study was to determine if endothelial function is altered with increasing age in healthy subjects. Method: The study population consisted of 30 elderly and 36 younger subjects free from major cardiovascular risk factors. Transthoracic echocardiography was performed for each subject to rule out structural heart disease. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery via ultrasound. Results: Baseline characteristics of the elderly and the younger group were similar, except for age (mean age: 71.3 ± 5.8 vs. 26.5 ± 7.2). Transthoracic echocardiography was normal in all subjects. FMD of the elderly group was significantly lower than the younger group (7.9 ± 3.1 in the elderly, 10.8 ± 1.9 in the younger group, p < 0.001). A negative relationship was found between FMD and age (r = –0.528, p < 0.001). Conclusion: It can be concluded that endothelial function detected by FMD declines with increasing age in healthy human subjects. Advanced age is a predictor of impaired endothelial function.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aging</subject><subject>Biological and medical sciences</subject><subject>Blood vessels</subject><subject>Brachial Artery - physiology</subject><subject>Cardiovascular disease</subject><subject>Clinical Section</subject><subject>Development. Metamorphosis. Moult. Ageing</subject><subject>Echocardiography</subject><subject>Endothelium, Vascular - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gerontology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Reference Values</subject><subject>Regional Blood Flow - physiology</subject><subject>Risk factors</subject><subject>Stroke Volume - physiology</subject><subject>Vasodilation - physiology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0304-324X</issn><issn>1423-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0M1LwzAYBvAgipvTg3eRICh4qL75aLsci84PEDyo4K1k-XCdWatJq_S_N7LiwFPg4cfzhgehQwIXhKTiEgAIFZDxLTQmnLIkBmwbjYEBTxjlryO0F8IyhkAJ7KIRmXJOUkrH6KnQX7JWRuPizeD7gIsQGlXJNibfVbvAs1o37cK4Sjp83Qfb1aqtmhpXNb4z0rWLHs-cNt71-KmbL41qwz7asdIFczC8E_RyM3u-ukseHm_vr4qHRLGMtAnNFKOWMDkXdGoJTVkmuTXMcDDcKqWVJhmkljKdWZDCilxLmgOTQudimrMJOlv3fvjmszOhLVdVUMY5WZumC2UOeZ4JQiI8-QeXTefr-LeS5jzuQBmP6HyNlG9C8MaWH75aSd-XBMrfmcu_maM9Hgq7-crojRx2jeB0ADIo6ayPG1fhz1FgAmiaRne0du_Svxm_KVrf-QFj_YvZ</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Yavuz, B.B.</creator><creator>Yavuz, B.</creator><creator>Sener, Dede D.</creator><creator>Cankurtaran, M.</creator><creator>Halil, M.</creator><creator>Ulger, Z.</creator><creator>Nazli, N.</creator><creator>Kabakci, G.</creator><creator>Aytemir, K.</creator><creator>Tokgozoglu, L.</creator><creator>Oto, A.</creator><creator>Ariogul, S.</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>88J</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M2R</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects</title><author>Yavuz, B.B. ; Yavuz, B. ; Sener, Dede D. ; Cankurtaran, M. ; Halil, M. ; Ulger, Z. ; Nazli, N. ; Kabakci, G. ; Aytemir, K. ; Tokgozoglu, L. ; Oto, A. ; Ariogul, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-26c32f13ab928f12536a4fe3e40e4fccdcd1605f23d6f0a9f97da2703a9d79873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aging</topic><topic>Biological and medical sciences</topic><topic>Blood vessels</topic><topic>Brachial Artery - physiology</topic><topic>Cardiovascular disease</topic><topic>Clinical Section</topic><topic>Development. Metamorphosis. Moult. Ageing</topic><topic>Echocardiography</topic><topic>Endothelium, Vascular - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gerontology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Reference Values</topic><topic>Regional Blood Flow - physiology</topic><topic>Risk factors</topic><topic>Stroke Volume - physiology</topic><topic>Vasodilation - physiology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yavuz, B.B.</creatorcontrib><creatorcontrib>Yavuz, B.</creatorcontrib><creatorcontrib>Sener, Dede D.</creatorcontrib><creatorcontrib>Cankurtaran, M.</creatorcontrib><creatorcontrib>Halil, M.</creatorcontrib><creatorcontrib>Ulger, Z.</creatorcontrib><creatorcontrib>Nazli, N.</creatorcontrib><creatorcontrib>Kabakci, G.</creatorcontrib><creatorcontrib>Aytemir, K.</creatorcontrib><creatorcontrib>Tokgozoglu, L.</creatorcontrib><creatorcontrib>Oto, A.</creatorcontrib><creatorcontrib>Ariogul, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Social Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Gerontology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yavuz, B.B.</au><au>Yavuz, B.</au><au>Sener, Dede D.</au><au>Cankurtaran, M.</au><au>Halil, M.</au><au>Ulger, Z.</au><au>Nazli, N.</au><au>Kabakci, G.</au><au>Aytemir, K.</au><au>Tokgozoglu, L.</au><au>Oto, A.</au><au>Ariogul, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects</atitle><jtitle>Gerontology (Basel)</jtitle><addtitle>Gerontology</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>54</volume><issue>3</issue><spage>153</spage><epage>156</epage><pages>153-156</pages><issn>0304-324X</issn><eissn>1423-0003</eissn><coden>GERNDJ</coden><abstract>Background: Aging is associated with an increased risk for atherosclerosis in which endothelial dysfunction is an early marker. Objective: The purpose of this study was to determine if endothelial function is altered with increasing age in healthy subjects. Method: The study population consisted of 30 elderly and 36 younger subjects free from major cardiovascular risk factors. Transthoracic echocardiography was performed for each subject to rule out structural heart disease. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery via ultrasound. Results: Baseline characteristics of the elderly and the younger group were similar, except for age (mean age: 71.3 ± 5.8 vs. 26.5 ± 7.2). Transthoracic echocardiography was normal in all subjects. FMD of the elderly group was significantly lower than the younger group (7.9 ± 3.1 in the elderly, 10.8 ± 1.9 in the younger group, p < 0.001). A negative relationship was found between FMD and age (r = –0.528, p < 0.001). Conclusion: It can be concluded that endothelial function detected by FMD declines with increasing age in healthy human subjects. Advanced age is a predictor of impaired endothelial function.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>18441522</pmid><doi>10.1159/000129064</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-324X |
| ispartof | Gerontology (Basel), 2008-01, Vol.54 (3), p.153-156 |
| issn | 0304-324X 1423-0003 |
| language | eng |
| recordid | cdi_karger_primary_129064 |
| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Adult Age Factors Aged Aging Biological and medical sciences Blood vessels Brachial Artery - physiology Cardiovascular disease Clinical Section Development. Metamorphosis. Moult. Ageing Echocardiography Endothelium, Vascular - physiology Female Fundamental and applied biological sciences. Psychology Gerontology Humans Male Middle Aged Reference Values Regional Blood Flow - physiology Risk factors Stroke Volume - physiology Vasodilation - physiology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T02%3A35%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_karge&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Advanced%20Age%20Is%20Associated%20with%20Endothelial%20Dysfunction%20in%20Healthy%20Elderly%20Subjects&rft.jtitle=Gerontology%20(Basel)&rft.au=Yavuz,%20B.B.&rft.date=2008-01-01&rft.volume=54&rft.issue=3&rft.spage=153&rft.epage=156&rft.pages=153-156&rft.issn=0304-324X&rft.eissn=1423-0003&rft.coden=GERNDJ&rft_id=info:doi/10.1159/000129064&rft_dat=%3Cproquest_karge%3E70776911%3C/proquest_karge%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=274522234&rft_id=info:pmid/18441522&rfr_iscdi=true |