Comparative Efficacy of Two Microdoses of a Potentized Homeopathic Drug, Arsenicum Album, to Ameliorate Toxicity Induced by Repeated Sublethal Injections of Arsenic Trioxide in Mice
Objectives: To evaluate the efficacy of 2 potentized homeopathic remedies of Arsenicum Album (Ars Alb) – 6C and 30C – in combating chronic arsenic toxicity induced by repeated sublethal injections in mice (Mus musculus). Methods: Mice were randomized and divided into sets: (1) normal (control 1); (2...
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| Veröffentlicht in: | Pathobiology (Basel) 2008-01, Vol.75 (3), p.156-170 |
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| creator | Banerjee, Pathikrit Bhattacharyya, Soumya Sundar Pathak, Surajit Naoual, Boujedaini Belon, Philippe Khuda-Bukhsh, Anisur Rahman |
| description | Objectives: To evaluate the efficacy of 2 potentized homeopathic remedies of Arsenicum Album (Ars Alb) – 6C and 30C – in combating chronic arsenic toxicity induced by repeated sublethal injections in mice (Mus musculus). Methods: Mice were randomized and divided into sets: (1) normal (control 1); (2) normal + succussed alcohol (control 2); (3) As 2 O 3 (0.016%) injected at 1 ml/100 g body weight every 7 days (treated); (4) As 2 O 3 injected + succussed alcohol (positive control); (5) As 2 O 3 injected + Ars Alb 6C (drug-fed); (6) As 2 O 3 injected + Ars Alb 30C (drug-fed). Cytogenetical endpoints like chromosome aberrations, micronuclei, mitotic index, sperm head abnormality and biochemical protocols like acid and alkaline phosphatases, aspartate and alanine aminotransferases, reduced glutathione, lipid peroxidation, catalase and succinate dehydrogenase were studied at 30, 60, 90 and 120 days. Results: Compared to controls, chromosome aberrations, micronuclei, sperm head abnormality frequencies and activities of acid and alkaline phosphatases, aspartate and alanine aminotransferases and lipid peroxidation were reduced in both drug-fed series, while mitotic index and activities of glutathione, catalase and succinate dehydrogenase were increased. Ars Alb 30C showed marginally better efficacy than Ars Alb 6C. Conclusion: Both remedies indicated potentials of use against arsenic intoxication. |
| doi_str_mv | 10.1159/000124976 |
| format | Article |
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Methods: Mice were randomized and divided into sets: (1) normal (control 1); (2) normal + succussed alcohol (control 2); (3) As 2 O 3 (0.016%) injected at 1 ml/100 g body weight every 7 days (treated); (4) As 2 O 3 injected + succussed alcohol (positive control); (5) As 2 O 3 injected + Ars Alb 6C (drug-fed); (6) As 2 O 3 injected + Ars Alb 30C (drug-fed). Cytogenetical endpoints like chromosome aberrations, micronuclei, mitotic index, sperm head abnormality and biochemical protocols like acid and alkaline phosphatases, aspartate and alanine aminotransferases, reduced glutathione, lipid peroxidation, catalase and succinate dehydrogenase were studied at 30, 60, 90 and 120 days. Results: Compared to controls, chromosome aberrations, micronuclei, sperm head abnormality frequencies and activities of acid and alkaline phosphatases, aspartate and alanine aminotransferases and lipid peroxidation were reduced in both drug-fed series, while mitotic index and activities of glutathione, catalase and succinate dehydrogenase were increased. Ars Alb 30C showed marginally better efficacy than Ars Alb 6C. Conclusion: Both remedies indicated potentials of use against arsenic intoxication.</description><identifier>ISSN: 1015-2008</identifier><identifier>EISSN: 1423-0291</identifier><identifier>DOI: 10.1159/000124976</identifier><identifier>PMID: 18550913</identifier><identifier>CODEN: PATHEF</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Acid Phosphatase - metabolism ; Alkaline Phosphatase ; Animals ; Arsenic ; Arsenic Poisoning - drug therapy ; Arsenic Poisoning - etiology ; Arsenic Poisoning - physiopathology ; Arsenicals - administration & dosage ; Arsenicals - adverse effects ; Arsenicals - therapeutic use ; Body weight ; Catalase - metabolism ; Chromosome Aberrations ; Chronic Disease ; Clinical outcomes ; Dehydrogenase ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Female ; Glutathione ; Homeopathic medicine ; Lipid Metabolism ; Male ; Materia Medica - administration & dosage ; Materia Medica - therapeutic use ; Mice ; Mitotic Index ; Mus musculus ; Original Paper ; Oxides - adverse effects ; Peroxidation ; Rodents ; Spermatozoa - pathology ; Succinate Dehydrogenase - metabolism ; Toxicity ; Transaminases - metabolism ; Treatment Outcome</subject><ispartof>Pathobiology (Basel), 2008-01, Vol.75 (3), p.156-170</ispartof><rights>2008 S. Karger AG, Basel</rights><rights>Copyright 2008 S. Karger AG, Basel.</rights><rights>Copyright (c) 2008 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-4d8a5d4863343b804e421b6ddb305cf3cdaf1447f73797a70fbcbd316ad29ae93</citedby><cites>FETCH-LOGICAL-c398t-4d8a5d4863343b804e421b6ddb305cf3cdaf1447f73797a70fbcbd316ad29ae93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,2423,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18550913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Banerjee, Pathikrit</creatorcontrib><creatorcontrib>Bhattacharyya, Soumya Sundar</creatorcontrib><creatorcontrib>Pathak, Surajit</creatorcontrib><creatorcontrib>Naoual, Boujedaini</creatorcontrib><creatorcontrib>Belon, Philippe</creatorcontrib><creatorcontrib>Khuda-Bukhsh, Anisur Rahman</creatorcontrib><title>Comparative Efficacy of Two Microdoses of a Potentized Homeopathic Drug, Arsenicum Album, to Ameliorate Toxicity Induced by Repeated Sublethal Injections of Arsenic Trioxide in Mice</title><title>Pathobiology (Basel)</title><addtitle>Pathobiology</addtitle><description>Objectives: To evaluate the efficacy of 2 potentized homeopathic remedies of Arsenicum Album (Ars Alb) – 6C and 30C – in combating chronic arsenic toxicity induced by repeated sublethal injections in mice (Mus musculus). Methods: Mice were randomized and divided into sets: (1) normal (control 1); (2) normal + succussed alcohol (control 2); (3) As 2 O 3 (0.016%) injected at 1 ml/100 g body weight every 7 days (treated); (4) As 2 O 3 injected + succussed alcohol (positive control); (5) As 2 O 3 injected + Ars Alb 6C (drug-fed); (6) As 2 O 3 injected + Ars Alb 30C (drug-fed). Cytogenetical endpoints like chromosome aberrations, micronuclei, mitotic index, sperm head abnormality and biochemical protocols like acid and alkaline phosphatases, aspartate and alanine aminotransferases, reduced glutathione, lipid peroxidation, catalase and succinate dehydrogenase were studied at 30, 60, 90 and 120 days. Results: Compared to controls, chromosome aberrations, micronuclei, sperm head abnormality frequencies and activities of acid and alkaline phosphatases, aspartate and alanine aminotransferases and lipid peroxidation were reduced in both drug-fed series, while mitotic index and activities of glutathione, catalase and succinate dehydrogenase were increased. Ars Alb 30C showed marginally better efficacy than Ars Alb 6C. Conclusion: Both remedies indicated potentials of use against arsenic intoxication.</description><subject>Acid Phosphatase - metabolism</subject><subject>Alkaline Phosphatase</subject><subject>Animals</subject><subject>Arsenic</subject><subject>Arsenic Poisoning - drug therapy</subject><subject>Arsenic Poisoning - etiology</subject><subject>Arsenic Poisoning - physiopathology</subject><subject>Arsenicals - administration & dosage</subject><subject>Arsenicals - adverse effects</subject><subject>Arsenicals - therapeutic use</subject><subject>Body weight</subject><subject>Catalase - metabolism</subject><subject>Chromosome Aberrations</subject><subject>Chronic Disease</subject><subject>Clinical outcomes</subject><subject>Dehydrogenase</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Evaluation, Preclinical</subject><subject>Female</subject><subject>Glutathione</subject><subject>Homeopathic medicine</subject><subject>Lipid Metabolism</subject><subject>Male</subject><subject>Materia Medica - administration & dosage</subject><subject>Materia Medica - therapeutic use</subject><subject>Mice</subject><subject>Mitotic Index</subject><subject>Mus musculus</subject><subject>Original Paper</subject><subject>Oxides - adverse effects</subject><subject>Peroxidation</subject><subject>Rodents</subject><subject>Spermatozoa - pathology</subject><subject>Succinate Dehydrogenase - metabolism</subject><subject>Toxicity</subject><subject>Transaminases - metabolism</subject><subject>Treatment Outcome</subject><issn>1015-2008</issn><issn>1423-0291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUlvFDEQRlsIRBY4cEfI4oIipcFbLz6OhkAiBYFgOLfcdjnx0N3ueCEM_yv_D09mlEicbLlevSr5K4pXBL8npBIfMMaEctHUT4pDwikrMRXkab5jUpUU4_agOAphnbEW1_h5cUDaqsKCsMPibunGWXoZ7W9AZ8ZYJdUGOYNWtw59sco77QKE7YtE31yEKdq_oNG5G8HNMl5bhT76dHWKFj7AZFUa0WLo03iKokOLEQbrsh3Qyv2xysYNuph0UtnQb9B3mCHXNPqR-gHitRxydQ0qWjfdj9w70crb3K4B2Wm7FLwonhk5BHi5P4-Ln5_OVsvz8vLr54vl4rJUTLSx5LqVleZtzRhnfYs5cEr6Wuue4UoZprQ0hPPGNKwRjWyw6VWvGamlpkKCYMfFu5139u4mQYjdaIOCYZATuBS6hleCCo7rTL79j1y75Ke8XEcpr_P8hmboZAflbw3Bg-lmb0fpNx3B3TbJ7iHJzL7ZC1M_gn4k99Fl4PUO-CX9FfhHYNf_Dwzdo20</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Banerjee, Pathikrit</creator><creator>Bhattacharyya, Soumya Sundar</creator><creator>Pathak, Surajit</creator><creator>Naoual, Boujedaini</creator><creator>Belon, Philippe</creator><creator>Khuda-Bukhsh, Anisur Rahman</creator><general>S. 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adverse effects</topic><topic>Peroxidation</topic><topic>Rodents</topic><topic>Spermatozoa - pathology</topic><topic>Succinate Dehydrogenase - metabolism</topic><topic>Toxicity</topic><topic>Transaminases - metabolism</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banerjee, Pathikrit</creatorcontrib><creatorcontrib>Bhattacharyya, Soumya Sundar</creatorcontrib><creatorcontrib>Pathak, Surajit</creatorcontrib><creatorcontrib>Naoual, Boujedaini</creatorcontrib><creatorcontrib>Belon, Philippe</creatorcontrib><creatorcontrib>Khuda-Bukhsh, Anisur Rahman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pathobiology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banerjee, Pathikrit</au><au>Bhattacharyya, Soumya Sundar</au><au>Pathak, Surajit</au><au>Naoual, Boujedaini</au><au>Belon, Philippe</au><au>Khuda-Bukhsh, Anisur Rahman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Efficacy of Two Microdoses of a Potentized Homeopathic Drug, Arsenicum Album, to Ameliorate Toxicity Induced by Repeated Sublethal Injections of Arsenic Trioxide in Mice</atitle><jtitle>Pathobiology (Basel)</jtitle><addtitle>Pathobiology</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>75</volume><issue>3</issue><spage>156</spage><epage>170</epage><pages>156-170</pages><issn>1015-2008</issn><eissn>1423-0291</eissn><coden>PATHEF</coden><abstract>Objectives: To evaluate the efficacy of 2 potentized homeopathic remedies of Arsenicum Album (Ars Alb) – 6C and 30C – in combating chronic arsenic toxicity induced by repeated sublethal injections in mice (Mus musculus). Methods: Mice were randomized and divided into sets: (1) normal (control 1); (2) normal + succussed alcohol (control 2); (3) As 2 O 3 (0.016%) injected at 1 ml/100 g body weight every 7 days (treated); (4) As 2 O 3 injected + succussed alcohol (positive control); (5) As 2 O 3 injected + Ars Alb 6C (drug-fed); (6) As 2 O 3 injected + Ars Alb 30C (drug-fed). Cytogenetical endpoints like chromosome aberrations, micronuclei, mitotic index, sperm head abnormality and biochemical protocols like acid and alkaline phosphatases, aspartate and alanine aminotransferases, reduced glutathione, lipid peroxidation, catalase and succinate dehydrogenase were studied at 30, 60, 90 and 120 days. Results: Compared to controls, chromosome aberrations, micronuclei, sperm head abnormality frequencies and activities of acid and alkaline phosphatases, aspartate and alanine aminotransferases and lipid peroxidation were reduced in both drug-fed series, while mitotic index and activities of glutathione, catalase and succinate dehydrogenase were increased. Ars Alb 30C showed marginally better efficacy than Ars Alb 6C. Conclusion: Both remedies indicated potentials of use against arsenic intoxication.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>18550913</pmid><doi>10.1159/000124976</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pathobiology (Basel), 2008-01, Vol.75 (3), p.156-170 |
| issn | 1015-2008 1423-0291 |
| language | eng |
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| source | MEDLINE; Karger Journals |
| subjects | Acid Phosphatase - metabolism Alkaline Phosphatase Animals Arsenic Arsenic Poisoning - drug therapy Arsenic Poisoning - etiology Arsenic Poisoning - physiopathology Arsenicals - administration & dosage Arsenicals - adverse effects Arsenicals - therapeutic use Body weight Catalase - metabolism Chromosome Aberrations Chronic Disease Clinical outcomes Dehydrogenase Dose-Response Relationship, Drug Drug Evaluation, Preclinical Female Glutathione Homeopathic medicine Lipid Metabolism Male Materia Medica - administration & dosage Materia Medica - therapeutic use Mice Mitotic Index Mus musculus Original Paper Oxides - adverse effects Peroxidation Rodents Spermatozoa - pathology Succinate Dehydrogenase - metabolism Toxicity Transaminases - metabolism Treatment Outcome |
| title | Comparative Efficacy of Two Microdoses of a Potentized Homeopathic Drug, Arsenicum Album, to Ameliorate Toxicity Induced by Repeated Sublethal Injections of Arsenic Trioxide in Mice |
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